Journal of Oral and Maxillofacial Surgery
Volume 61, Issue 9 , Pages 1115-1117 , September 2003

Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic

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  8. Frith JC, Monkkonen J, Blackburn GM, et al.  Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosire 5”-(beta,gamma-dichloromethylene) triphosphate, by mammalian cells in vitro. J Bone Miner Res. 1997;12:1358
  9. Tenenbaum HC, Shelemay A, Girard B, et al.  Bisphosphonates and periodontics (potential applications for regulation of bone mass in the periodontium and other therapeutic/diagnostic uses). J Periodontol. 2002;73:813
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PII: S0278-2391(03)00720-1

doi: 10.1016/S0278-2391(03)00720-1

Journal of Oral and Maxillofacial Surgery
Volume 61, Issue 9 , Pages 1115-1117 , September 2003