Journal of Oral and Maxillofacial Surgery
Volume 63, Issue 5 , Pages 586-591 , May 2005

Anchoring Dental Implant in Tissue-Engineered Bone Using Composite Scaffold: A Preliminary Study in Nude Mouse Model

  • Fulin Chen, PhD

      Affiliations

    • Attending Doctor (adjunct position), Department of Oral and Maxillofacial Surgery, Qindu Hospital, Xi’an, People’s Republic of China; and Assistant Professor, Xi’da-RegeMed Institute of Tissue Engineering and Regenerative Medicine, Faculty of Life Science, Northwest University, Xi’an, People’s Republic of China.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Chen: Department of Oral and Maxillofacial Surgery, Qin Du Hospital, FMMU, Kang Fu Road 7, Xi’an, 710032, People’s Republic of China
    • ,
  • Hongwei Ouyang, PhD

      Affiliations

    • Research Fellow, Xi’da-RegeMed Institute of Tissue Engineering and Regenerative Medicine, Faculty of Life Science, Northwest University, Xi’an, People’s Republic of China.
    • ,
  • Xue Feng, PhD

      Affiliations

    • Attending Doctor, Department of Orthodontics, Qindu Hospital, Xi’an, People’s Republic of China.
    • ,
  • Zhan Gao, MD

      Affiliations

    • Resident, Department of Oral and Maxillofacial Surgery, Qindu Hospital, Xi’an, People’s Republic of China.
    • ,
  • Yaowu Yang, PhD

      Affiliations

    • Attending Doctor, Department of Oral and Maxillofacial Surgery, Qindu Hospital, Xi’an, People’s Republic of China.
    • ,
  • Xiaohui Zou, PhD

      Affiliations

    • Research Fellow, Xi’da-RegeMed Institute of Tissue Engineering and Regenerative Medicine, Faculty of Life Science, Northwest University, Xi’an, People’s Republic of China.
    • ,
  • Tieshan Liu, PhD

      Affiliations

    • Vice Head, Xi’da-RegeMed Institute of Tissue Engineering and Regenerative Medicine, Faculty of Life Science, Northwest University, Xi’an, People’s Republic of China.
    • ,
  • Guifang Zhao, PhD

      Affiliations

    • Head, Xi’da-RegeMed Institute of Tissue Engineering and Regenerative Medicine, Faculty of Life Science, Northwest University, Xi’an, P.R. China
    • ,
  • Tianqiu Mao, MD

      Affiliations

    • Professor, Department of Oral and Maxillofacial Surgery, Qindu Hospital, Xi’an, People’s Republic of China.

References 

  1. Maiorana C , Santoro F . Maxillary and mandibular bone reconstruction with hip grafts and implants using Frialit-2 implants . Int J Periodontics Restorative Dent . 2002;22:221
  2. Navarro Vila C , Borja Morant A , Cuesta M , et al.   Aesthetic and functional reconstruction with the trapezius osseomyocutaneous flap and dental implants in oral cavity cancer patients . J Craniomaxillofac Surg . 1996;24:322
  3. Foster RD , Anthony JP , Sharma A , et al.   Vascularized bone flaps versus nonvascularized bone grafts for mandibular reconstruction (An outcome analysis of primary bony union and endosseous implant success) . Head Neck . 1999;21:66
  4. Pogrel MA , Podlesh S , Anthony JP , et al.   A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects . J Oral Maxillofac Surg . 1997;55:1200
  5. Forrest C , Boyd B , Manktelow R , et al.   The free vascularised iliac crest tissue transfer (Donor site complications associated with eighty-two cases) . Br J Plast Surg . 1992;45:89
  6. Nemzek JA , Arnoczky SP , Swenson CL . Retroviral transmission in bone allotransplantation. The effects of tissue processing . Clin Orthop . 1996;324:275
  7. Bucholz RW , Carlton A , Holmes RE . Hydroxyapatite and tricalcium phosphate bone graft substitutes . Orthop Clin North Am . 1987;18:323
  8. Hutmacher DW , Sittinger M . Periosteal cells in bone tissue engineering . Tissue Eng . 2003;9(suppl 1):S45
  9. Vacanti CA , Bonassar LJ . An overview of tissue engineered bone . Clin Orthop . 2000;367(suppl):S375
  10. Jadlowiec JA , Celil AB , Hollinger JO . Bone tissue engineering (Recent advances and promising therapeutic agents) . Expert Opin Biol Ther . 2003;3:409
  11. Hutmacher DW . Scaffolds in tissue engineering bone and cartilage . Biomaterials . 2000;21:2529
  12. Burg KJ , Porter S , Kellam JF . Biomaterial developments for bone tissue engineering . Biomaterials . 2000;21:2347
  13. Petite H , Viateau V , Bensaid W , et al.   Tissue-engineered bone regeneration . Nat Biotechnol . 2000;18:959
  14. Chen F , Mao T , Tao K , et al.   Bone graft in the shape of human mandibular condyle reconstruction via seeding marrow-derived osteoblasts into porous coral in a nude mice model . J Oral Maxillofac Surg . 2002;60:1155
  15. Chen F , Chen S , Tao K , et al.   Marrow-derived osteoblasts seeded into porous natural coral to prefabricate a vascularised bone graft in the shape of a human mandibular ramus (Experimental study in rabbits) . Br J Oral Maxillofac Surg . 2004;42:532
  16. Chen F , Mao T , Tao K , et al.   Injectable bone . Br J Oral Maxillofac Surg . 2003;41:240
  17. Schantz JT , Teoh SH , Lim TC , et al.   Repair of calvarial defects with customized tissue-engineered bone grafts, I. Evaluation of osteogenesis in a three-dimensional culture system . Tissue Eng . 2003;9(suppl 1):S113
  18. Bidic SM , Calvert JW , Marra K , et al.   Rabbit calvarial wound healing by means of seeded Caprotite scaffolds . J Dent Res . 2003;82:131
  19. Begley CT , Doherty MJ , Mollan RA , et al.   Comparative study of the osteoinductive properties of bioceramic, coral and processed bone graft substitutes . Biomaterials . 1995;16:1181
  20. Doherty MJ , Schlag G , Schwarz N , et al.   Biocompatibility of xenogeneic bone, commercially available coral, a bioceramic and tissue sealant for human osteoblasts . Biomaterials . 1994;15:601
  21. Mora F , Ouhayoun JP . Clinical evaluation of natural coral and porous hydroxyapatite implants in periodontal bone lesions (Results of a 1-year follow-up) . J Clin Periodontol . 1995;22:877
  22. Kim CK , Choi EJ , Cho KS , et al.   Periodontal repair in intrabony defects treated with a calcium carbonate implant and guided tissue regeneration . J Periodontol . 1996;67:1301
  23. Kruyt MC , de Bruijn JD , Wilson CE , et al.   Viable osteogenic cells are obligatory for tissue-engineered ectopic bone formation in goats . Tissue Eng . 2003;9:327
  24. Weng Y , Cao Y , Silva CA , et al.   Tissue-engineered composites of bone and cartilage for mandible condylar reconstruction . J Oral Maxillofac Surg . 2001;59:185
  25. Kon E , Muraglia A , Corsi A , et al.   Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones . J Biomed Mater Res . 2000;49:328
  26. Kildal M , Wei FC , Chang YM . Free vascularized bone grafts for reconstruction of traumatic bony defects of mandible and maxilla . World J Surg . 2001;25:1067
  27. Cheung LK , Leung AC . Dental implants in reconstructed jaws (Implant longevity and peri-implant tissue outcomes) . J Oral Maxillofac Surg . 2003;61:1263
  28. Kim WS , Vacanti JP , Cima L , et al.   Cartilage engineered in predetermined shapes employing cell transplantation on synthetic biodegradable polymers . Plast Reconstr Surg . 1994;94:233

 Drs Chen and Ouyang contributed equally to this report.

 This research was supported by National Natural Science Foundation of P. R. China (Nos. 30370373 and 30170245).

PII: S0278-2391(05)00098-4

doi: 10.1016/j.joms.2005.01.007

Journal of Oral and Maxillofacial Surgery
Volume 63, Issue 5 , Pages 586-591 , May 2005

Article Tools

* Image Usage & Resolution