Journal of Oral and Maxillofacial Surgery
Volume 64, Issue 2 , Pages 180-188, February 2006

Effects of Low-Intensity Pulsed Ultrasound on Healing of Mandibular Fractures: An Experimental Study in Rabbits

  • Özgür Erdoǧan, DDS

      Affiliations

    • Research Assistant, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Adana, Turkey
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Erdoǧan: Cukurova Universitesi Dis Hekimligi Fakultesi, ADCH Cerrahisi AD, 01330, Balcali, Adana, Turkey
    • ,
  • Emin Esen, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Adana, Turkey
    • ,
  • Yakup Üstün, DDS, PhD

      Affiliations

    • Research Assistant, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Adana, Turkey
    • ,
  • Mehmet Kürkçü, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Adana, Turkey
    • ,
  • Tolga Akova, DDS, PhD

      Affiliations

    • Research Assistant, Department of Prosthodontics, Faculty of Dentistry, Çukurova University, Adana, Turkey
    • ,
  • Gülfiliz Gönlüşen, MD

      Affiliations

    • Professor, Department of Pathology, Faculty of Medicine, Çukurova University, Adana, Turkey
    • ,
  • Hakan Uysal, DDS, PhD

      Affiliations

    • Professor, Department of Prosthodontics, Faculty of Dentistry, Çukurova University, Adana, Turkey
    • ,
  • Filiz Çevlik, MD

      Affiliations

    • Research Assistant, Department of Pathology, Faculty of Medicine, Çukurova University, Adana, Turkey

Purpose

Pulsed ultrasonic waves have been shown to accelerate fracture healing of the long bones. The aim of this study was to evaluate the effects of low-intensity pulsed ultrasound (LIPU) on healing of mandibular fractures.

Materials and Methods

Thirty skeletally mature male New Zealand rabbits were used. Animals underwent unilateral mandibular osteotomy. The bone segments were repositioned and fixed with miniplates and miniscrews. Half of the animals received daily ultrasound treatment, 20 min/day, for 20 days. Ultrasound signals consisted of a 1.5-MHz pressure wave administered in pulses of 200 μsec with an average temporal and spatial intensity of 30 mW/cm2. Animals in the control group received sham application. All of the animals were killed on postoperative day 22. Three-point bending test, digital radiodensitometric analysis, and histologic and histomorphometric examinations were performed on the harvested hemimandibles. The data were statistically analyzed.

Results

Biomechanical tests revealed significant improvement in the mechanical properties of the healing bone in the LIPU-treated group. This was supported by histologic and radiologic findings.

Conclusions

Results of this study suggest that LIPU improves the bone healing of mandibular fractures in rabbits.

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 This study was supported and funded by the Çukurova University Academic Research Projects Unit (project No. DHF2003D1).

PII: S0278-2391(05)01677-0

doi:10.1016/j.joms.2005.10.027

Journal of Oral and Maxillofacial Surgery
Volume 64, Issue 2 , Pages 180-188, February 2006

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