Journal of Oral and Maxillofacial Surgery
Volume 64, Issue 3 , Pages 415-423 , March 2006

Selective Immunohistochemical Comparison of Polymorphous Low-Grade Adenocarcinoma and Adenoid Cystic Carcinoma

  • David Beltran, DMD

      Affiliations

    • Resident, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr August: Massachusetts General Hospital, Department of Oral and Maxillofacial Surgery, 55 Fruit Street, Warren 1201, Boston, MA 02114
    • ,
  • William C. Faquin, MD, PhD

      Affiliations

    • Assistant Professor, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    • ,
  • George Gallagher, DMD, DMSc

      Affiliations

    • Professor, Department of Oral and Maxillofacial Pathology, Boston University Goldman School of Dental Medicine, Boston, MA
    • ,
  • Meredith August, DMD, MD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA

References 

  1. Freedman PD , Lumerman HL . Lobular carcinoma of intraoral minor salivary gland origin (Report of twelve cases) . Oral Surg Oral Med Oral Pathol . 1983;56:157
  2. Batsakis JG , Pinkston GR , Luna MA , et al.   Adenocarcinomas of the oral cavity (A clinicopathologic study of terminal duct carcinomas) . J Laryngol Otol . 1983;97:825
  3. Evans HL , Batsakis JG . Polymorphous low-grade adenocarcinoma of minor salivary glands (A study of 14 cases of a distinctive neoplasm) . Cancer . 1984;53:935
  4. Norberg L , Dardick I . The need for clinical awareness of polymorphous low-grade adenocarcinoma (A review) . J Otolaryngol . 1992;21:2
  5. Waldron CA , El-Mofty SK , Gnepp DR . Tumors of the intra-oral minor salivary glands (A demographic and histologic study of 426 cases) . Oral Surg Oral Med Oral Pathol . 1988;66:323
  6. Gnepp DR , Chen JC , Warren C . Polymorphous low-grade adenocarcinoma of minor salivary gland (An immunohistochemical and clinicopathologic study) . Am J Surg Pathol . 1988;12:461
  7. Anderson C , Krutchkoff D , Pederson C , et al.   Polymorphous low-grade adenocarcinoma of minor salivary gland (A clinicopathologic and comparative immunohistochemical study) . Mod Pathol . 1990;3:76
  8. Mitchell DA , Eveson JW , Ord RA . Polymorphous low grade adenocarcinoma of minor salivary glands (A report of three cases) . Br J Oral Maxillofac Surg . 1989;27:494
  9. Szanto PA , Luna MA , Tortoledo ME , et al.   Histologic grading of adenoid cystic carcinoma of salivary glands . Cancer . 1984;54:1062
  10. Vrielinck LJ , Ostyn F , van Damme B , et al.   The significance of perineural spread in adenoid cystic carcinoma of the major and minor salivary glands . Int J Oral Maxillofac Surg . 1988;17:190
  11. Luna MA , el-Naggar A , Batsakis JG , et al.   Flow cytometric DNA content of adenoid cystic carcinoma of submandibular gland (Correlation of histologic features and prognosis) . Arch Otolaryngol Head Neck Surg . 1990;116:1291
  12. Spiro RH , Huvos AG . Stage means more than grade in adenoid cystic carcinoma . Am J Surg . 1984;164:623
  13. Ampil FL , Misra RP . Factors influencing survival of patients with adenoid cystic carcinoma of the salivary glands . J Oral Maxillofac Surg . 1987;45:1005
  14. Cowie VJ , Pointon RC . Adenoid cystic carcinoma of the salivary glands . Clin Radiol . 1984;35:331
  15. Matsuba HM , Spector GJ , Thawley SE , et al.   Adenoid cystic salivary gland carcinoma (A histopathologic review of treatment failure patterns) . Cancer . 1986;57:519
  16. Shingaki S , Saito R , Kawasaki T , et al.   Adenoid cystic carcinoma of the major and minor salivary glands (A clinicopathologic study of 17 cases) . J Maxillofac Surg . 1986;14:53
  17. Simpson JR , Thawley SE , Matsuba HM . Adenoid cystic salivary gland carcinoma (Treatment with irradiation and surgery) . Radiology . 1984;151:509
  18. Matsuba HM , Thawley SE , Simpson JR , et al.   Adenoid cystic carcinoma of major and minor salivary gland origin . Laryngoscope . 1984;94:1316
  19. Arber DA , Tamayo R , Weiss LM . Paraffin section detection of the c-kit gene product (CD117) in human tissues (Value in the diagnosis of mast cell disorders) . Hum Pathol . 1998;28:298
  20. Mino M , Pilch BZ , Faquin WC . Expression of KIT (CD117) in neoplasms of the head and neck (An ancillary marker for adenoid cystic carcinoma) . Mod Pathol . 2003;16:1224
  21. Jeng YM , Lin CY , Hsu HC . Expression of the c-kit protein is associated with certain subtypes of salivary gland carcinoma . Cancer Lett . 2000;154:107
  22. Host VA , Marshall CE , Moskaluk CA , et al.   Kit protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma . Mod Pathol . 1999;12:956
  23. Penner CR , Folpe AL , Budnick SD . C-Kit expression distinguishes salivary gland adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma . Mod Pathol . 2002;15:687
  24. Cohn ML , Said-Al-Naif N , Bell WC . Immunoreactivity of salivary gland tumors for CK-7, CK-20 and c-kit . Chicago, IL: United States and Canadian Academy of Pathology Annual Meeting; 2002; Abstract #910
  25. Edwards PC , Bhuiya T , Kelsch RD . C-kit expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and monomorphic adenoma . Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 2003;95:586
  26. Murakimi M , Ohtani I , Hojo H , et al.   Immunohistochemical evaluation with Ki-67 (An application to salivary gland tumours) . J Laryngol Otol . 1992;106:35
  27. Ogawa I , Miyauchi M , Takata T , et al.   Proliferative activity of salivary gland in pleomorphic adenomas and myoepitheliomas as evaluated by the proliferating cell nuclear antigen (PCNA) labeling index (lI) . J Oral Pathol Med . 1993;22:447
  28. Skalova A , Leivo I , von Boguslawsky K , et al.   Cell proliferation correlates with prognosis in acinic cell carcinomas of salivary gland origin (Immunohistochemical study of 30 cases using the MIB antibody in formalin-fixed paraffin sections) . J Pathol . 1994;173:13
  29. Skalova A , Lehtonen G , von Boguslawsky K , et al.   Prognostic significance of cell proliferation in mucoepidermoid carcinomas of salivary gland (Clinicopathological study using MIB1 antibody in paraffin sections) . Hum Pathol . 1994;25:929
  30. Zang L , Hashimura K , Qin C , et al.   Immunoreactivity of proliferating cell nuclear antigen in salivary gland tumours (An assessment of growth potential) . Virchows Arch A Pathol Anat Histopathol . 1993;422:481
  31. Skalova A , Simpson RHW , Lehtonen H , et al.   Assessment of proliferative activity using the MIB1 antibody helps to distinguish polymorphous low grade adenocarcinoma from adenoid cystic carcinoma of salivary glands . Pathol Res Pract . 1997;193:695
  32. Vargas H , Sudilovsky D , Kaplan MJ , et al.   Mixed tumor, polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma of the salivary gland (Pathogenic implications and differential diagnosis by ki-67, (MIB1), BCL2, and S-100 immunohistochemistry) . Appl Immunohistochem Mol Morphol . 1997;5:8
  33. Lazzaro B , Cleveland D . p53 and ki-67 antigen expression in small oral biopsy specimens of salivary gland tumors . Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 2000;89:613
  34. Prasad AR , Savera AT , Gown AM , et al.   The myoepithelial immunophenotype in 135 benign and malignant salivary gland tumors other than pleomorphic adenoma . Arch Pathol Lab Med . 1999;123:801
  35. Scarpellini F , Marucci G , Foschini MP . Myoepithelial differentiation markers in salivary gland neoplasia . Pathologica . 2001;93:662
  36. Hirano T , Gluckman JL , deVries EJ . The expression of alpha vascular smooth-muscle actin in salivary gland tumors . Arch Otolaryngol Head Neck Surg . 1990;116:692
  37. Gugliotta P , Sapino A , Macri L , et al.   Specific demonstration of myoepithelial cells by anti-alpha smooth muscle actin antibody . J Histochem Cytochem . 1988;36:659
  38. Skalli O , Ropraz P , Trzeciak A , et al.   A monoclonal antibody against alpha smooth muscle actin (A new probe for smooth muscle differentiation) . J Cell Biol . 1986;103:2787
  39. Moringa S , Nakajima T , Shimosato Y . Normal and neoplastic myoepithelial cells in salivary glands (An immunoperoxidase study) . Hum Pathol . 1987;18:1219
  40. Araujo VC , Sousa SO , Carvalho YR , et al.   Application of immunohistochemistry to the diagnosis of salivary gland tumors . Appl Immunohistochem Mol Morphol . 2000;8:195
  41. Loyola AM , Sousa SO , Araujo NS , et al.   Study of minor salivary gland mucoepidermoid carcinoma differentiation based on immunohistochemical expression of cytokeratins, vimentin and muscle-specific actin . Oral Oncol . 1998;34:112
  42. Savera AT , Sloman A , Huvos AG , et al.   Myoepithelial carcinoma of the salivary glands (A clinicopathologic study of 25 patients) . Am J Surg Pathol . 2000;24:761
  43. Tralongo V , Daniele E . Epithelial-myoepithelial carcinoma of the salivary glands (A review of literature) . Anticancer Res . 1998;18:603
  44. Wilson RW , Moran CA . Epithelial-myoepithelial carcinoma of the lung (Immunohistochemical and ultrastructural observations and review of the literature) . Hum Pathol . 1997;28:631
  45. Kilpatrick SE , Hitchcock MG , Kraus MD , et al.   Mixed tumors and myoepitheliomas of soft tissue (A clinicopathologic study of 19 cases with a unifying concept) . Am J Surg Pathol . 1997;21:13
  46. Jones H , Moshtael F , Simpson RHW . Immunoreactivity of alpha smooth muscle actin in salivary gland tumours (A comparison with S100 protein) . J Clin Pathol . 1992;45:938
  47. Chen JC , Gnepp DR , Bedrossian CWM . Adenoid cystic carcinoma of the salivary gland (An immunohistochemical analysis) . Oral Surg Oral Med Oral Pathol . 1988;65:316
  48. Araujo V , Sousa S , Jaeger M , et al.   Characterization of the cellular component of polymorphous low-grade adenocarcinoma by immunohistochemistry and electron microscopy . Oral Oncol . 1999;35:164

PII: S0278-2391(05)01810-0

doi: 10.1016/j.joms.2005.11.027

Journal of Oral and Maxillofacial Surgery
Volume 64, Issue 3 , Pages 415-423 , March 2006

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