Journal of Oral and Maxillofacial Surgery
Volume 64, Issue 3 , Pages 397-401 , March 2006

Immunohistochemical Investigations of the Influence of Botulinum Toxin A on the Immunoreactivity of nNOS in the Parotid Gland of the Rat

  • Maik Ellies, MD

      Affiliations

    • Specialist in ENT, Department of Otorhinolaryngology, Head and Neck Surgery
    • Corresponding Author InformationAddress for correspondence and reprint requests to Dr Ellies: Universitäts-HNO-Klinik, Robert-Koch-Str. 40, D-37075 Göttingen, Germany
    • ,
  • Sebastian Schütz

      Affiliations

    • Medical Student, Department of Otorhinolaryngology, Head and Neck Surgery
    • ,
  • Fabio Quondamatteo, MD

      Affiliations

    • Specialist in Anatomy, Department of Histology
    • ,
  • Rainer Laskawi, MD

      Affiliations

    • Specialist in ENT, Department of Otorhinolaryngology, Head and Neck Surgery

References 

  1. Lomniczi A , Suburo AM , Elverdin JC , et al.   Role of nitric oxide in salivary secretion . Neuroimmunomodulation . 1998;5:226
  2. Takai N , Uchihashi K , Higuchi K , et al.   Localization of neuronal-constitutive nitric oxide synthase and secretory regulation by nitric oxide in the rat submandibular and sublingual glands . Arch Oral Biol . 1999;44:745
  3. Ellies M , Laskawi R , Schütz S , et al.   Immunohistochemical evidence of nNOS and changes after intraglandular application of botulinum toxin A in cephalic salivary glands of adult rats . ORL J Otorhinolaryngol Relat Spec . 2003;65:140
  4. Ellies M , Rohrbach S , Laskawi R . Hypersalivation . In:  Laskawi R ,  Roggenkämper P editor. Botulinumtoxin-Therapie in Kopf-Hals-Bereich . Munich: Urban & Vogel Verlag; 2004;p. 322–338
  5. Ellies M , Laskawi R , Rohrbach-Volland S , et al.   Sekretionshemmung exokriner Drüsen des Kopf-Hals-Bereiches durch Applikation von Botulinum Toxin A . Therapie seltener Krankheitsbilder . 2001;HNO 49:807
  6. Ellies M , Laskawi R , Rohrbach-Volland S , et al.   Botulinum toxin to reduce saliva flow (Selected indications for ultrasound-guided toxin application into salivary glands) . Laryngoscope . 2002;112:82
  7. Hess A , Bloch W , Rocker J , et al.   In vitro expression of inducible nitric oxide synthase in the nasal mucosa of guinea pigs after incubation with lipopolysaccharides or cytokines . Eur Arch Otorhinolaryngol . 1998;235:448
  8. Rohrbach S , Olthoff A , Laskawi R , et al.   Neuronal nitric oxide synthase-immunoreactivity . ORL J Otorhinolaryngol Relat Spec . 2002;64:330
  9. Lohinai Z , Burghardt B , Zelles T , et al.   Nitric oxide modulates salivary amylase and fluid, but not epidermal growth factor secretion in conscious rats . Life Sci . 1999;11:953
  10. Chiba T , Tanaka K . A target specific pathway from nitric oxide synthase immunoreactive preganglionic sympathetic to superior cervical ganglion neurons innervating the submandibular salivary gland . J Auton Nerv Syst . 1998;71:139
  11. Seifert G , Miehlke A , Haubrich J , et al.   Diseases of the salivary glands . New York, NY: Georg Thieme Verlag; 1986;
  12. Leiros CP , Rosignoli F , Genaro AM , et al.   Differential activation of nitric oxide synthase through muscarinic acetylcholine receptors in rat salivary glands . J Auton Nerv Syst . 2000;79:99
  13. Olthoff A , Rohrbach S , Faber M , et al.   Neuronal nitric oxide synthase immunoreactivity in the nasal mucosa of patients with idiopathic and allergic rhinitis . ORL J Otorhinolaryngol Relat Spec . 2002;64:180
  14. Ellies M , Rohrbach-Volland S , Arglebe C , et al.   Successful management of drooling with botulinum toxin A in neurologically disabled children . Neuropediatrics . 2002;33:327
  15. Ellies M , Laskawi R , Rohrbach-Volland S , et al.   Up-to-date report of botulinum toxin therapy in patients with drooling caused by different etiologies . J Oral Maxillofac Surg . 2003;61:454
  16. Ellies M , Gottstein U , Rohrbach-Volland S , et al.   Reduction of salivary flow with botulinum toxin (extended report on 33 patients with drooling, salivary fistulas, and sialadenitis) . Laryngoscope . 2004;114:1856

 Received from the University of Göttingen, Göttingen, Germany

PII: S0278-2391(05)01828-8

doi: 10.1016/j.joms.2005.11.029

Journal of Oral and Maxillofacial Surgery
Volume 64, Issue 3 , Pages 397-401 , March 2006

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