Distraction Osteogenesis in Irradiated Rabbit Mandibles With Adjunctive Hyperbaric Oxygen Therapy
Purpose
The purpose of this study was to evaluate the effect of hyperbaric oxygen therapy on bone regeneration during distraction of irradiated rabbit mandibles.
Materials and Methods
Twenty New Zealand white rabbits were randomly sub-divided into 4 groups. Group 1 served as control, group 2 received preoperative radiation therapy, group 3 received pre- and postoperative hyperbaric oxygen (HBO) therapy, and group 4 received preoperative radiation therapy and pre- and postoperative HBO therapy. All rabbits underwent a corticotomy of the left body of the mandible after placement of a distraction device. Distraction, at a rate of 1 mm/day and a rhythm of 1 turn/day, began after a 3-day latency period for 14 days. Thirty days after completion of the distraction protocol, the animals were euthanized, and histomorphometric and radiographic data of the distraction segments were obtained.
Results
Histomorphometric analysis of new bone fill was greatest in the non-irradiated groups compared to groups receiving radiation therapy, regardless of HBO therapy (P = .03). Pre-corticotomy bone density measurements showed a significant increase in bone density over time (P = .0007). This resulted in a significant relationship between HBO therapy, radiation therapy, and time (P = .0050).
Conclusions
The results of the study support the use of HBO therapy during distraction osteogenesis. Any additional therapeutic benefit of HBO therapy in irradiated bone would require additional investigation.
⁎Major, US Army; Formerly, Chief Resident, Oral and Maxillofacial Surgery Service, Eisenhower Army Medical Center, Fort Gordon, GA; Currently, Staff Oral and Maxillofacial Surgeon, Darnell Army Community Hospital, Fort Hood, TX
†Colonel (retired) US Army; Formerly, Program Director, Oral and Maxillofacial Surgery Residency Training Program, Eisenhower Army Medical Center, Fort Gordon, GA; Currently, Private Practice, Columbia, SC
‡Radiation Therapist, Department of Radiation Oncology, Medical College of Georgia School of Dentistry, Augusta, GA
§Associate Professor, Oral and Maxillofacial Surgery Service, Medical College of Georgia School of Dentistry, Augusta, GA
∥Formerly, Chief, Veterinary Services, Department of Clinical Investigation, Eisenhower Army Medical Center, Fort Gordon, GA; Currently, Lieutenant Colonel, US Army, Institute of Surgical Research, Brooke Army Medical Center, San Antonio, TX
¶Senior Research Medical Technologist, Department of Clinical Investigation, Eisenhower Army Medical Center, Fort Gordon, GA
#Colonel, US Army; Chief, Oral and Maxillofacial Surgery Service, and Residency Program Director, Eisenhower Army Medical Center, Fort Gordon, GA
Address correspondence and reprint request to Dr Baur: Oral and Maxillofacial Surgery Service, Bldg 300, First Floor, DDEAMC, 300 Hospital Road, Fort Gordon, GA 30905-5650
The views and opinions expressed herein are those of the authors and do not necessarily reflect those of the Department of the Army or the Department of Defense.
ABSTRACT