Journal of Oral and Maxillofacial Surgery
Volume 64, Issue 7 , Pages 1005-1009 , July 2006

Effect of Alendronate on Endosseous Implant Integration: An In Vivo Study in Rabbits

  • Guillermo E. Chacon, DDS

      Affiliations

    • Assistant Professor, Interim Section Head, Residency Program Director, Oral and Maxillofacial Surgery, Section of Oral and Maxillofacial Surgery, Anesthesiology, and Oral and Maxillofacial Pathology, College of Dentistry, The Ohio State University, Columbus, OH.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Chacon: 305 W, 12th Avenue, Box 182357, Columbus, OH 43218-2357
    • ,
  • Eric A. Stine, DDS, MS

      Affiliations

    • Formerly, Chief Resident, Department of Oral and Maxillofacial Surgery, College of Dentistry, The Ohio State University, Columbus, OH; Currently, Private Practice in Oral and Maxillofacial Surgery, St. Cloud, MN.
    • ,
  • Peter E. Larsen, DDS

      Affiliations

    • Professor, Oral and Maxillofacial Surgery, Section of Oral and Maxillofacial Surgery, Anesthesiology, and Oral and Maxillofacial Pathology, College of Dentistry, The Ohio State University, Columbus, OH.
    • ,
  • F. Michael Beck, DDS, MA

      Affiliations

    • Associate Professor, Section of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH.
    • ,
  • Edwin A. McGlumphy, DDS, MS

      Affiliations

    • Associate Professor, Director of Implant Prosthodontics, Section of Restorative and Prosthodontics, College of Dentistry, The Ohio State University, Columbus, OH.

References 

  1. Sonis ST , Fazio RC , Fang L . Principles and Practice of Oral Medicine . Philadelphia, PA: Saunders; 1984;
  2. Wade JP . Rheumatology: 15. Osteoporosis . Can Med Assoc J . 2001;165:45
  3. Starck WJ , Epker BN . Failure of osseointegrated dental implants after biphosphonate therapy for osteoporosis (A case report) . Int J Oral Maxillofac Implants . 1995;10:74
  4. Meraw SJ , Reeve CM . Qualitative analysis of peripheral peri-implant bone and influence of alendronate sodium on early bone regeneration . J Periodontol . 1999;70:1228
  5. Meraw SJ , Reeve CM , Wollan PC . Use of alendronate in peri-implant defect regeneration . J Periodontol . 1999;70:151
  6. Mochida Y , Bauer TW , Akisue T . Alendronate does not inhibit early bone apposition to hydroxyapatite-coated total joint implants (a preliminary study) . J Bone Joint Surg Am . 2002;84-A:226
  7. Frenkel SR , Jaffe WL , Della Valle C , et al.   The effect of alendronate and implant surface on bone integration and remodeling in a canine model . J Biomed Mater Res . 2001;58:645
  8. Narai S , Naghata S . Effects of alendronate on the removal torque of implants in rats with induced osteoporosis . Int J Oral Maxillofac Implants . 2003;18:218
  9. Cordioli G , Majzoub Z , Piattelli A , et al.   Removal torque and histomorphometric investigation of 4 different titanium surfaces (An experimental study in the rabbit tibia) . Int J Oral Maxillofac Implants . 2000;15:668
  10. Wennerberg A , Ektessabi A , Albrektsson T , et al.   A 1-year follow-up of implants of differing surface roughness placed in rabbit bone . Int J Oral Maxillofac Implants . 1997;12:486
  11. Pan J , Shirota T , Ohno K , et al.   Effect of ovariectomy on bone remodeling adjacent to hydroxyapatite-coated implants in the tibia of mature rats . J Oral Maxillofac Surg . 2000;8:877
  12. Mori H , Manabe M , Kurachi Y , et al.   Osseointegration of dental implants in rabbit bone with low mineral density . J Oral Maxillofac Surg . 1997;55:351
  13. Lugero GG , Caparbo V , Guzzo ML , et al.   Histomorphometric evaluation of titanium implants in osteoporotic rabbits . Implant Dentistry . 2000;4:303
  14. Mashiba T , Turner CH , Hirano T , et al.   Effects of high-dose etidronate treatment on microdamage accumulation and biomechanical properties in beagle bone before occurrence of spontaneous fractures . Bone . 2001;29:271
  15. Rodan GA , Seedor JG , Balena R . Preclinical pharmacology of alendronate . Osteoporos Int . 1993;3:S7
  16. Reginster JYL . Treatment of bone in elderly subjects (calcium, vitamin D, Flour, bisphosphonates, calcitonin) . Hormone Res . 1995;43:83
  17. Carr AB , Larsen PE , Papazoglou E , et al.   Reverse torque failure of screw shaped implants in baboons (Baseline data for abutment torque application) . Int J Oral Maxillofac Implants . 1995;10:167

 This study was financed in part by a grant from Altiva Corporation.

PII: S0278-2391(06)00096-6

doi: 10.1016/j.joms.2006.01.007

Journal of Oral and Maxillofacial Surgery
Volume 64, Issue 7 , Pages 1005-1009 , July 2006

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