Journal of Oral and Maxillofacial Surgery
Volume 64, Issue 8 , Pages 1232-1236 , August 2006

Experimental Evaluation of the Effects of Zoledronic Acid on Regenerate Bone Formation and Osteoporosis in Mandibular Distraction Osteogenesis

  • A. Alper Pampu, DDS, PhD

      Affiliations

    • Resident, Department of Oral and Maxillofacial Surgery, Selcuk University, Faculty of Dentistry, Konya, Turkey.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Pampu: Department of Oral and Maxillofacial Surgery, Selcuk University, Faculty of Dentistry, 42079 Kampus, Konya, Turkey
    • ,
  • Doğan Dolanmaz, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Selcuk University, Faculty of Dentistry, Konya, Turkey.
    • ,
  • Hakan H. Tüz, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Oral and Maxillofacial Surgery, Kırıkkale University, Faculty of Dentistry Kırıkkale, Turkey.
    • ,
  • Aydın Karabacakoglu, MD

      Affiliations

    • Assistant Professor, Department of Radiology, Meram Medical Faculty, Selcuk University, Konya, Turkey.

References 

  1. McCarthy JG , Schreiber J , Karp N , et al.   Lengthening the human mandible by gradual distraction . Plast Reconstr Surg . 1992;89:1
  2. Tsubota S , Tsuchiya H , Shinokawa Y , et al.   Transplantation of osteoblast-like cells to the distracted callus in rabbits . J Bone Joint Surg . 1999;81B:125
  3. Okazaki H , Kurokawa T , Nakamura K , et al.   Stimulation of bone formation by recombinant fibroblast growth factor-2 in callotasis bone lengthening of rabbits . Calcif Tissue Int . 1999;64:542
  4. Stewart KJ , Weyand B , van’t Hof RJ , et al.   A quantitative analysis of the effect of insulin-like growth factor-1 infusion during mandibular distraction osteogenesis in rabbits . Br J Plast Surg . 2000;26:619
  5. Little DG , Comell MS , Briody J , et al.   Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis. A study in immature rabbits . J Bone Joint Surg . 2001;83B:1069
  6. Williams PR , Smith NC , Cooke-Yarborough C , et al.   Bisphosphonates and nephrocalcinosis in a rabbit leg lengthening model (A histological and therapeutic comparison) . Pharmacol Toxicol . 2001;89:149
  7. Raschke MJ , Bail H , Windhagen HJ , et al.   Recombinant growth hormone accelerates bone regenerate consolidation in distraction osteogenesis . Bone . 1999;24:81
  8. Hagino T , Hamada Y . Accelerating bone formation and earlier healing after using demineralized bone matrix for limb lengthening in rabbits . J Orthop Res . 1999;17:232
  9. Al Ruhaimi KA . Effect of calcium sulphate on the rate of osteogenesis in distracted bone . Int J Oral Maxillofac Surg . 2001;30:228
  10. Hagiwara T , Bell WH . Effect of electrical stimulation on mandibular distraction osteogenesis . J Craniomaxillofac Surg . 2000;28:12
  11. Chen T , Berenson J , Vescio R , et al.   Pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with bone metastases . Clin Pharmacol . 2002;42:1228
  12. Wedemeyer C , Knoch F , Pingsmann A , et al.   Stimulation of bone formation by zoledronic acid in particle-induced osteolysis . Biomaterials . 2005;26:3719
  13. Li EC , Davis LE . Zoledronic acid (A new parenteral bisphosphonate) . Clin Ther . 2003;25:2669
  14. Kos M , Luczak K , Godzinski J , et al.   Treatment of monostotic fibrous dysplasia with pamidronate . J Craniomaxillofac Surg . 2004;32:10
  15. Vasikaran SD . Bisphosphonates (An overview with special reference to alendronate) . Ann Clin Biochem . 2001;38:608
  16. Evans CE , Braidman IP . Effects of two novel bisphosphonates on bone cells in vitro . Bone Miner . 1994;26:95
  17. Dunford JE , Thompson K , Coxon FP , et al.   Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates . J Pharmacol Exp Ther . 2001;296:235
  18. Benford HL , McGowan NW , Helfrich MH , et al.   Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro . Bone . 2001;28:465
  19. Aronson J , Harrison B , Body C , et al.   Mechanical induction of osteogenesis (The importance of pin rigidity) . J Pediatr Orthop . 1988;8:396
  20. McCarthy JG , Stelnicki EJ , Mehrara BJ , et al.   Distraction osteogenesis of the craniofacial skeleton . Plast Reconstr Surg . 2001;107:1812
  21. Constantino PD , Friedman CD , Shindo ML , et al.   Experimental mandibular regrowth by distraction osteogenesis (Long-term results) . Arch Otolaryngol Head Neck Surg . 1993;119:511
  22. Schulten AJ , Zimmermann CE , Glowacki J . Osteoblastic bone resorption around intraosseous screws in rat and pig mandibles . Microsc Res Tech . 2003;61:533
  23. Eyres KS , Bell MJ , Kanis JA . New bone formation during leg lengthening (Evaluated by dual energy X-ray absorptiometry) . J Bone Joint Surg (Br) . 1993;75B:96
  24. Maffuli N , Cheng JC , Sher A , et al.   Dual-energy X-ray absorptiometry predicts bone formation in lower limb callotasis lengthening . Ann R Coll Surg Engl . 1997;79:250
  25. Bilston LE , Little DG , Smith NC , et al.   ZA improves the mechanical properties of normal and healing bone . Clin Biomech . 2002;17:716
  26. Williams PR , Smith NC , Cook-Yarborough C , et al.   Bisphosphonates and nephrocalcinosis in a rabbit leg lengthening model (A histological and therapeutic comparison) . Pharmacol Toxicol . 2001;89:149
  27. Marx RE , Sawatari Y , Michel Fortin M , et al.   Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws (Risk factors, recognition, prevention, and treatment) . J Oral Maxillofac Surg . 2005;63:1567
  28. Schwartz HC . Bisphosphonate-associated osteonecrosis of the jaws . J Oral Maxillofac Surg . 2005;63:1555
  29. Ilizarov GA . Clinical application of the tension-stress effect for limb lengthening . Clin Orthop Rel Res . 1990;250:8
  30. Little DG , Cornell MS , Hile MS , et al.   Effect of pamidronate on distraction osteogenesis and fixator-related osteoporosis . Injury . 2001;32(suppl 4):SD14
  31. Paley D . Problems, obstacles, and complications of limb lengthening by the Ilizarov technique . Clin Orthop . 1990;250:81
  32. Chen T , Berenson J , Vescio R , et al.   Pharmacokinetics and pharmacodynamics of zoledronic acid in cancer patients with bone metastases . J Clin Pharmacol . 2002;42:1228
  33. Komuro Y , Takato T , Harii K , et al.   The histologic analysis of distraction osteogenesis of the mandible in rabbits . Plast Reconstr Surg . 1994;94:152

 This research was supported by Selçuk University Scientific Research Projects.

PII: S0278-2391(06)00563-5

doi: 10.1016/j.joms.2006.04.038

Journal of Oral and Maxillofacial Surgery
Volume 64, Issue 8 , Pages 1232-1236 , August 2006

Article Tools

* Image Usage & Resolution