Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 5 , Pages 870-874 , May 2007

Clinical and Histopathologic Study of the Use of Gangliosides for Nerve Regeneration in Rats After Axonotmesis

  • Joaquim Celestino S. Neto, DDS, MSc

      Affiliations

    • PhD Candidate, Department of Oral and Maxillofacial Surgery, University of Pernambuco, Recife, Brazil.
    • ,
  • Belmiro C.E. Vasconcelos, DDS, PhD

      Affiliations

    • Senior Lecturer in Oral and Maxillofacial Surgery and Director, Postgraduate Programs in Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, University of Pernambuco, Recife, Brazil.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Vasconcelos: Faculdade de Odontologia de Pernambuco, Departamento de Cirurgia e Traumatologia BMF, Av General Newton Cavalcanti, 1650 Camaragibe–PE, 54753-220 Brazil
    • ,
  • Ana Paula V. Sobral, DDS, PhD

      Affiliations

    • Senior Lecturer in Oral Pathology, Department of Oral and Maxillofacial Surgery, University of Pernambuco, Recife, Brazil.
    • ,
  • Valdemiro Amaro da Silva Jr, DDS, PhD

      Affiliations

    • Senior Lecturer in Morphology, Department of Oral and Maxillofacial Surgery, University of Pernambuco, Recife, Brazil.
    • ,
  • Ricardo Viana Bessa Nogueira, DDS, MSc

      Affiliations

    • PhD Candidate, Department of Oral and Maxillofacial Surgery, University of Pernambuco, Recife, Brazil.

References 

  1. Akal UK, Sayan NB, Aydogan S, et al. Evaluation of the neurosensory deficiencies of oral and maxillofacial region following surgery. Int J Oral Maxillofac Surg. 2000;29:331
  2. Vasconcelos BC, Gay-Escoda C. Facial nerve repair with expanded polytetrafluoroethylene and collagen conduits: An experimental study in the rabbit. J Oral Maxillofac Surg. 2000;58:1257
  3. Amico-Roxas M, Caruso A, Trombadore S, et al. Ganglioside antinociceptive effects in rodents. Arch Int Pharmacodyn Ther. 1984;272:103
  4. Mendez-Otero R, Cavalcante LA. Functional role of gangliosides in neuronal motility. Prog Mol Subcell Biol. 2003;32:97
  5. Thanos PK, Okajima S, Terzis JK. Ultrastructure and cellular biology of nerve regeneration. J Reconstr Microsurg. 1998;14:423
  6. Bullens RW, O’Hanlon GM, Wagner E, et al. Roles of complex gangliosides at the neuromuscular junction. Ann N Y Acad Sci. 2003;998:401
  7. Danielsen N, Dahlin LB, Lee YF, et al. Axonal growth in mesothelial chambers: The role of the distal nerve segment. Scand J Plast Reconstr Surg. 1983;17:119
  8. Nachemson AK. Axonal regeneration and growth direction in square-shaped mesothelial chambers. Scand J Plast Reconstr Surg Hand Surg. 1988;22:199
  9. Weis J, Schroder JM. Differential effects of nerve, muscle, and fat tissue on regenerating nerve fibers in vivo. Muscle Nerve. 1989;12:723
  10. Vyas AA, Schnaar RL. Brain gangliosides: Functional ligands for myelin stability and the control of nerve regeneration. Biochimie. 2001;83:677
  11. Vyas AA, Patel HV, Fromholt SE, et al. Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration. Proc Natl Acad Sci USA. 2002;11:8412
  12. Montovani JC. In: Experimental study of nervous regeneration in the sciatic and facial nerves in rats: Action of n-acetylneuraminic acid. Doctoral thesis, State University of Sao Paulo; 1988;p. 191
  13. Montovani JC, Prado RG, Bacchi CE. Experimental surgery of the facial nerve: Evaluation of the intraperitoneal use of exogenous gangliosides. Rev Laryngol Otol Rhinol (Bord). 1995;116:163
  14. Itoh M, Fukumoto S, Baba N, et al. Prevention of the death of the rat axotomized hypoglossal nerve and promotion of its regeneration by bovine brain gangliosides. Glycobiology. 1999;9:1247
  15. Itoh M, Fukumoto S, Iwamoto T, et al. Specificity of carbohydrate structures of gangliosides in the activity to regenerate the rat axotomized hypoglossal nerve. Glycobiology. 2001;11:125

PII: S0278-2391(06)01339-5

doi: 10.1016/j.joms.2006.06.298

Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 5 , Pages 870-874 , May 2007

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