Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 5 , Pages 847-854, May 2007

Biological Assessment of Porous-Implant Hydroxyapatite Combined With Periosteal Grafting in Maxillary Defects

  • Paulo H.F. Caria, DDS, MS, PhD

      Affiliations

    • Professor, Department of Morphology, Piracicaba Dental School, State University of Campinas, São Paulo, Brazil.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Caria: Department of Morphology, Piracicaba Dental School–UNICAMP, Av. Limeira, 901 Piracicaba, São Paulo, 13414-903 Brazil
    • ,
  • Elizabeth Y. Kawachi, ScB, MS, PhD

      Affiliations

    • Chemist, Institute of Chemistry, State University of Campinas, São Paulo, Brazil.
    • ,
  • Celso A. Bertran, ScB, MS, PhD

      Affiliations

    • Associate Professor, Chemistry Department, Technological Institute of Aeronautics, São José dos Campos, São Paulo, Brazil.
    • ,
  • José A. Camilli, ScB, MS, PhD

      Affiliations

    • Professor, Institute of Biology, State University of Campinas, São Paulo, Brazil.

Purpose

To investigate the use of porous hydroxyapatite (HA) combined with periosteal graft to repair an induced maxillary bone defect.

Materials and Methods

A defect was produced in the premaxillary bone of rats. Four groups were used: 1) those treated with the mucoperiosteal graft from the premaxilla; 2) those treated with HA combined with mucoperiosteal graft from the premaxilla; 3) those treated with HA combined with periosteal graft from the femur; and 4) those treated with periosteal graft from the femur.

Results

The radiographic aspects from all groups showed no signs of bone formation after 2 weeks. After 16 weeks, there was evidence of points of radiolucency inside the HA implants. Cell proliferation occurred from the periosteum covering the defect. Bone tissue grew from the defect margin to inside the defect in all cases. Mature bone was seen around the HA implants after 8 and 16 weeks.

Conclusion

The periosteal graft provides satisfactory support to the HA implant, allowing the growth of new bone.

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 The authors thank CAPES, CNPQ, and FAPESP for financial support.

PII: S0278-2391(06)01349-8

doi:10.1016/j.joms.2006.05.059

Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 5 , Pages 847-854, May 2007

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