Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 3 , Pages 439-443 , March 2007

Cultured Epithelial Autografts in the Treatment of Facial Skin Defects: Clinical Outcome

  • Doris Maria Kim, MD

      Affiliations

    • Resident, Department of Oral and Maxillofacial Surgery, Clinical Navigation and Robotics, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Kim: Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Department of Oral and Maxillofacial Surgery, Clinical Navigation and Robotics, Augustenburger Platz 1, 13353 Berlin, Germany
    • ,
  • Oliver Schwerdtner, MD, DMD

      Affiliations

    • Oral-Maxillofacial Surgeon, Department of Oral and Maxillofacial Surgery, Clinical Navigation and Robotics, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    • ,
  • Andrea-Maria Schmidt-Westhausen, DMD

      Affiliations

    • Department Head, Department of Oral Surgery and Dental Radiology, Zentrum für Zahnmedizin, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    • ,
  • Andreas Kage, MD

      Affiliations

    • Attending Physician, Institute of Laboratory Medicine and Pathobiochemistry, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    • ,
  • Martin Klein, MD, DMD

      Affiliations

    • Assistant Medical Director, Department of Oral and Maxillofacial Surgery, Clinical Navigation and Robotics, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.

References 

  1. Tsai CY, Ueda M, Hata K, et al. Clinical results of cultured epithelial cell grafting in the oral and maxillofacial region. J Craniomaxillofac Surg. 1997;25:4
  2. Rives JM, Cantaloube D, Ainaud P, et al. Role of autografts of cultured epidermis in the treatment of deep burns of the face (Preliminary results). Ann Chir Plast Esthet. 1995;40:286
  3. O’Connor NE, Mulliken JB, Banks-Schlegel S, et al. Grafting of burns with cultured epithelium prepared from autologous epidermal cells. Lancet. 1981;10:75
  4. Gallico GG, O’Connor NE, Compton CC, et al. Cultured epithelial autografts for giant congenital nevi. Plast Reconstr Surg. 1989;84:1
  5. Sabolinski ML, Alvarez O, Auletta M, et al. Cultured skin as a ‘smart material’ for healing wounds: Experience in venous ulcers. Biomaterials. 1996;17:311
  6. Gallico GG, O’Connor NE, Compton CC, et al. Permanent coverage of large burn wounds with autologous cultured epithelium. N Engl J Med. 1984;311:448
  7. Eisenberg M, Llewelyn D. Surgical management of hands in children with recessive dystrophic epidermolysis bullosa: Use of allogeneic composite cultured skin grafts. Br J Plast Surg. 1998;51:608
  8. Bannasch H, Föhn M, Unterberg T, et al. Gewebeersatz (tissue engineering) von dermis und epidermis. Chirurg. 2003;74:802
  9. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells. Cell. 1975;6:331
  10. Ziegler UE, Debus ES, Keller HP, et al. Hautersatzverfahren bei chronischen wunden. Zentralbl Chir. 2001;126(suppl 1):71
  11. Hollander DA, Gutt CN, Falk S, et al. Rekonstruktion ausgedehnter weichteilverluste durch transplantation autologer dermaler und epidermaler äquivalente. Zentralbl Chir. 2004;129:29
  12. Przybilski M, Deb R, Erdmann D, et al. Aktuelle Trends in der entwicklung von hautersatzmaterialien. Chirurg. 2004;75:579
  13. Coulomb B, Lebreton C, Dubertret L. Influence of human dermal fibroblasts on epidermalization. J Invest Dermatol. 1989;92:122
  14. Krejci NC, Cuono CB, Langdon RC, et al. In vitro reconstruction of skin: Fibroblasts facilitate keratinocyte growth and differentiation on acellular reticular dermis. J Invest Dermatol. 1991;97:843
  15. Lysaght MJ, Hazlehurst AL. Tissue engineering: The end of the beginning. Tissue Eng. 2004;10:309
  16. Dellambra E, Golisano O, Bondanza S, et al. Downregulation of 14-3-3 sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes. J Cell Biol. 2000;149:1117

 This study was supported by the BMBF (Bundesministerium fuer Bildung und Forschung).

PII: S0278-2391(06)01378-4

doi: 10.1016/j.joms.2005.12.070

Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 3 , Pages 439-443 , March 2007

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