Lack of Association Between Proliferative Verrucous Leukoplakia and Human Papillomavirus Infection

Bagan, Jose V.; Jimenez, Yolanda; Murillo, Judith; Gavaldá, Carmen; Poveda, Rafael; Scully, Crispian; Alberola, Trinidad M.; Torres-Puente, Manuela; Pérez-Alonso, Manuel

doi:10.1016/j.joms.2005.12.066

« Previous Next »Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 1 , Pages 46-49, January 2007

Lack of Association Between Proliferative Verrucous Leukoplakia and Human Papillomavirus Infection

Jose V. Bagan, MD, PhD
- Professor of Oral Medicine, Oral Medicine, Valencia University; Chairman, Department of Stomatology, University General Hospital, Valencia, Spain.
- Address correspondence and reprint requests to Dr Bagan: Hospital General Universitario, Servicio de Estomatología, Avda/Tres Cruces s/n, 46014 Valencia, Spain
Yolanda Jimenez, MD, PhD
- Consultant, Oral Medicine, Valencia University; Department of Stomatology, University General Hospital, Valencia, Spain.
Judith Murillo, MD
- Consultant, Oral Medicine, Valencia University; Department of Stomatology, University General Hospital, Valencia, Spain.
Carmen Gavaldá, MDS, PhD
- Consultant, Oral Medicine, Valencia University; Department of Stomatology, University General Hospital, Valencia, Spain.
Rafael Poveda, MD, PhD
- Consultant, Oral Medicine, Valencia University; Department of Stomatology, University General Hospital, Valencia, Spain.
Crispian Scully, MD, MDS, PhD
- Professor of Oral Medicine, International Centres for Excellence in Dentistry, Eastman Dental Institute for Oral Health Care Sciences University College London, London, United Kingdom.
Trinidad M. Alberola, PhD
- Consultant, Sistemas Genómicos SL, Unidad de Oncología Molecular, División Biomédica, Paterna, Spain.
Manuela Torres-Puente, PhD
- Consultant, Sistemas Genómicos SL, Unidad de Oncología Molecular, División Biomédica, Paterna, Spain.
Manuel Pérez-Alonso, PhD
- Professor, Sistemas Genómicos SL, Unidad de Oncología Molecular, División Biomédica, Paterna, Spain; Department of Genetics, University of Valencia, Burjasot, Spain.

Purpose

To analyze proliferative verrucous leukoplakia (PVL) for the presence of human papillomavirus (HPV) in different stages of the disease.

Materials and Methods

We studied 13 patients with PVL. In 10 patients (76.9%), a lesional biopsy was taken and frozen at −40°C. Four patients were instructed to mouth rinse with sterile sera. The biopsy and rinse samples were analyzed for HPV by PCR.

Results

We did not detect HPV infection in the PVL tissue or in the oral rinse of any of the 13 patients in any stage of the disease analyzed, neither in oral squamous cell carcinoma nor in the simple hyperkeratosis.