Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 1 , Pages 46-49 , January 2007

Lack of Association Between Proliferative Verrucous Leukoplakia and Human Papillomavirus Infection

  • Jose V. Bagan, MD, PhD

      Affiliations

    • Professor of Oral Medicine, Oral Medicine, Valencia University; Chairman, Department of Stomatology, University General Hospital, Valencia, Spain.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Bagan: Hospital General Universitario, Servicio de Estomatología, Avda/Tres Cruces s/n, 46014 Valencia, Spain
    • ,
  • Yolanda Jimenez, MD, PhD

      Affiliations

    • Consultant, Oral Medicine, Valencia University; Department of Stomatology, University General Hospital, Valencia, Spain.
    • ,
  • Judith Murillo, MD

      Affiliations

    • Consultant, Oral Medicine, Valencia University; Department of Stomatology, University General Hospital, Valencia, Spain.
    • ,
  • Carmen Gavaldá, MDS, PhD

      Affiliations

    • Consultant, Oral Medicine, Valencia University; Department of Stomatology, University General Hospital, Valencia, Spain.
    • ,
  • Rafael Poveda, MD, PhD

      Affiliations

    • Consultant, Oral Medicine, Valencia University; Department of Stomatology, University General Hospital, Valencia, Spain.
    • ,
  • Crispian Scully, MD, MDS, PhD

      Affiliations

    • Professor of Oral Medicine, International Centres for Excellence in Dentistry, Eastman Dental Institute for Oral Health Care Sciences University College London, London, United Kingdom.
    • ,
  • Trinidad M. Alberola, PhD

      Affiliations

    • Consultant, Sistemas Genómicos SL, Unidad de Oncología Molecular, División Biomédica, Paterna, Spain.
    • ,
  • Manuela Torres-Puente, PhD

      Affiliations

    • Consultant, Sistemas Genómicos SL, Unidad de Oncología Molecular, División Biomédica, Paterna, Spain.
    • ,
  • Manuel Pérez-Alonso, PhD

      Affiliations

    • Professor, Sistemas Genómicos SL, Unidad de Oncología Molecular, División Biomédica, Paterna, Spain; Department of Genetics, University of Valencia, Burjasot, Spain.

References 

  1. Hansen LS, Olson JA, Silverman S. Proliferative verrucous leukoplakia (A long-term study of thirty patients). Oral Surg Oral Med Oral Pathol. 1985;60:285
  2. Batsakis JG, Suarez P, El-Naggar AK. Proliferative verrucous leukoplakia and its related lesions. Oral Oncol. 1999;35:354
  3. Bagan JV, Murillo J, Poveda R, et al. Proliferative verrucous leukoplakia: Unusual locations of oral squamous cell carcinomas, and field cancerization as shown by the appearance of multiple OSCCs. Oral Oncol. 2004;40:440
  4. Eversole LR. Papillary lesions of the oral cavity: Relationship to human papillomaviruses. J Calif Dent Assoc. 2000;28:922
  5. Ostwald C, Rutsatz K, Schweder J, et al. Human papillomavirus 6/11, 16 and 18 in oral carcinomas and benign oral lesions. Med Microbiol Immunol (Berl). 2003;192:145
  6. Palefsky JM, Silverman S, Abdel-Salaam M, et al. Association between proliferative verrucous leukoplakia and infection with human papillomavirus type 16. J Oral Pathol Med. 1995;24:193
  7. Fettig A, Pogrel Ma, Silverman S, et al. Proliferative verrucous leukoplakia of the gingiva. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:723
  8. Bagan JV, Jimenez Y, Sanchis JM, et al. Proliferative verrucous leukoplakia; High incidence of gingival squamous cell carcinoma. J Oral Pathol Med. 2003;32:379
  9. Summersgill KF, Smith EM, Levy BT, et al. Human papillomavirus in the oral cavities of children and adolescents. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:62
  10. Smith EM, Summersgill KF, Allen J, et al. Human papillomavirus and risk of laryngeal cancer. Ann Otol Rhinol Laryngol. 2000;109:1069
  11. Gravitt PE, Peyton CL, Alessi TQ, et al. Improved amplification of genital human papillomaviruses. J Clin Microbiol. 2000;38:357
  12. Coutlee F, Gravitt P, Kornegay J, et al. Use of PGMY primers in L1 consensus PCR improves detection of human papillomavirus DNA in genital samples. J Clin Microbiol. 2002;40:902
  13. Gravitt PE, Peyton CL, Alessi TQ, et al. Improved amplification of genital human papillomaviruses. J Clin Microbiol. 2000;38:357
  14. Silverman S, Gorsky M. Proliferative verrucous leukoplakia: A follow-up study of 54 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84:154
  15. Zakrzewska JM, Lopes V, Speight P, et al. Proliferative verrucous leukoplakia: A report of ten cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82:396
  16. Navarro CM, Sposto MR, Sgavioli-Massucato EM, et al. Transformation of proliferative verrucous leukoplakia to oral carcinoma: A ten years follow-up. Med Oral. 2004;9:229
  17. Campisi G, Giovannelli L, Ammatuna P, et al. Proliferative verrucous vs conventional leukoplakia: No significantly increased risk of HPV infection. Oral Oncol. 2004;40:835
  18. Gopalakrishnan R, Weghorst CM, Lehman TA, et al. Mutated and wild-type p53 expression and HPV integration in proliferative verrucous leukoplakia and oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83:471

PII: S0278-2391(06)01382-6

doi: 10.1016/j.joms.2005.12.066

Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 1 , Pages 46-49 , January 2007

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