Comparison of a Bolus of Fentanyl With an Infusion of Alfentanil During Target-Controlled Propofol Infusion in Third Molar Extraction Under Conscious Sedation

Kwak, Hyun J.; Kim, Ji Y.; Kwak, Young L.; Park, Won S.; Lee, Kyung C.

doi:10.1016/j.joms.2005.11.112

« Previous Next »Journal of Oral and Maxillofacial Surgery
Volume 64, Issue 11 , Pages 1577-1582, November 2006

Comparison of a Bolus of Fentanyl With an Infusion of Alfentanil During Target-Controlled Propofol Infusion in Third Molar Extraction Under Conscious Sedation

Hyun J. Kwak, MD
- Assistant Professor, Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and Science, Gil Medical Center, Incheon, Korea.
Ji Y. Kim, MD
- Lecturer, Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and Science, Gil Medical Center, Incheon, Korea.
Young L. Kwak, MD
- Associate Professor, Department of Anesthesiology and Pain Medicine, and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Won S. Park, DDS
- Fellow, Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, Korea.
Kyung C. Lee, MD
- Professor, Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and Science, Gil Medical Center, Incheon, Korea.
- Address correspondence and reprint requests to Dr Lee: Department of Anesthesiology and Pain Medicine, Gachon Medical School, Gil Medical Center, 1198 Guwol-dong Namdong-gu, Incheon 405-760, Korea

Purpose

This study was designed to compare hemodynamic changes, respiratory depression, and patient satisfaction between a bolus of fentanyl and an infusion of alfentanil during target-controlled propofol infusion in third molar extraction under conscious sedation.

Patients and Methods

Forty patients were randomly assigned to receive either a bolus of fentanyl (n = 24) or an infusion of alfentanil (n = 16) in combination with target-controlled propofol infusion. Hemodynamic changes, respiratory depression, sedation, and cooperation scores were recorded during surgery and patient satisfaction scores were assessed after surgery.

Results

Changes in mean blood pressure, heart rate, or oxygen saturation within and between the groups were not significant throughout the procedure. There were no significant differences in sedation, cooperation, and patient satisfaction scores between the 2 groups.

Conclusion

Because there was no difference in hemodynamic variables and patient satisfaction scores between a bolus of fentanyl and an infusion of alfentanil during target-controlled propofol infusion, both combinations are suitable for conscious sedation in third molar extraction.