Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 4 , Pages 640-644 , April 2007

Odontogenic Keratocyst: To Decompress or Not to Decompress? A Comparative Study of Decompression and Enucleation Versus Resection/Peripheral Ostectomy

  • Antonia Kolokythas, DDS

      Affiliations

    • Maxillofacial Oncology Fellow, Department of Oral and Maxillofacial Surgery, University of Maryland, Baltimore, MD.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Kolokythas: University of Maryland, Department of Oral and Maxillofacial Surgery, 419 West Redwood Street, Suite 410, Baltimore, MD 21201-1754
    • ,
  • Rui P. Fernandes, DMD, MD

      Affiliations

    • Assistant Professor of Surgery, Division of Maxillofacial Surgery, Department of Surgery, University of Florida College of Medicine, Jacksonville, FL.
    • ,
  • Alexander Pazoki, DDS, MD

      Affiliations

    • Assistant Professor and Program Director, Department of Oral and Maxillofacial Surgery, University of Maryland, Baltimore, MD.
    • ,
  • Robert A. Ord, DDS, MD

      Affiliations

    • Professor and Chairman, Department of Oral and Maxillofacial Surgery, University of Maryland, Baltimore, MD.

References 

  1. Philipsen HP. On keratocysts in the jaws. Tandlaegebladet. 1956;60:963
  2. Pindborg JJ, Hansen J. Studies on odontogenic cyst epithelium, II: Clinical and roentgenologic aspects of odontogenic keratocysts. Acta Pathol Microbiol Scand. 1963;58:283
  3. Thawley SE, Panje WR, Batsakis JG, et al. In: 2nd edition. Comprehensive Management of Head and Neck Tumors. Vol 2:Philadelphia: WB Saunders; 1999;p. 1556
  4. Shear M. In: Cysts of the Oral Region. 2nd edition. Boston: Wright–PSG; 1983;p. 4
  5. Blanas N, Freud B, Schwartz M, et al. Systemic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol. 2000;90:553
  6. Stoelinga PJ. Long-term follow-up on keratocysts treated according to a defined protocol. Int J Oral Maxillofac Surg. 2001;30:14
  7. Schmidt BL, Pogrel MA. The use of enucleation and liquid nitrogen cryotherapy in the management of odontogenic keratocysts. J Oral Maxillofac Surg. 2001;59:720
  8. Norifumi N, Mitsuyasu T, Mitsuyasu Y, et al. Marsupialization of odontogenic keratocysts: Long-term follow-up analysis of the effects and changes in growth characteristics. Oral Surg Oral Med Oral Pathol. 2002;94:543
  9. Hsun-Tau C. Odontogenic keratocyst: A clinical experience in Singapore. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86:573
  10. Irvine GH, Bowerman JE. Mandibular keratocysts: Surgical management. Br J Oral Maxillofac Surg. 1985;23:204
  11. Pogrel MA, Jordan RCK. Marsupialization as a definitive treatment of odontogenic keratocyst. J Oral Maxillofac Surg. 2004;62:651
  12. Rogerson KC. Gorlin’s syndrome: An update on diagnosis and management. Oral Maxillofac Clin North Am. 1991;3:155
  13. Stoeligna PJW. The incidence, multiple presentation and recurrence of aggressive cysts of the jaws. J Craniomaxillofac Surg. 1988;16:184
  14. Williams TP. Surgical treatment of odontogenic keratocysts. Oral Maxillofac Clin North Am. 1991;3:137
  15. Fonseca RJ, Willimas TP, Stewart JCB. Oral and Maxillofacial Surgery. In: Surgical Pathology. Vol 5:Philadelphia: WB Saunders; 2000;p. 297
  16. Marker P, Brondum N, Clausen PP, et al. Treatment of large odontogenic keratocyst by decompression and later cystectomy: A long–term follow-up and a histologic study of 23 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82:122
  17. Williams TP, Connor FA. Surgical management of odontogenic keratocyst: Aggressive approach. J Oral Maxillofac Surg. 1997;3:329
  18. Voorsmith RACA, Stoeligna PJ, Van Haelst UJGM. The management of keratocysts. J Maxillofac Surg. 1998;9:228
  19. Brondum N, Jensen VJ. Recurrence of keratocysts and decompression treatment: A long-term follow-up of forty-four cases. Oral Surg Oral Med Oral Pathol. 1991;72:265
  20. Jensen J, Sindet-Peterson S, Krants S. A comparative study of treatment of keratocysts by enucleation or enucleation combined with cryotherapy. J Craniomaxillofac Surg. 1988;16:362
  21. Emerson TG, Whitlock RIH, Jones JM. Involvement of soft tissues by odontogenic keratocyst. Br J Oral Maxillofac Surg. 1972;9:181
  22. Partridge M, Towers JF. The primordial cyst (odontogenic keratocyst): Its tumor-like characteristics and behavior. Br J Oral Maxillofac Surg. 1987;25:271
  23. Jackson IT, Potparic Z, Fasching M, et al. Penetration of the skull bases by dissecting keratocyst. J Craniomaxillofac Surg. 1993;21:319
  24. Chuong R, Donoff RB, Guralnick W. The odontogenic keratocyst. J Oral Maxillofac Surg. 1982;40:797
  25. Worrall SF. Recurrent odontogenic keratocyst within the temporalis muscle. Br J Oral Maxillofac Surg. 1992;30:59
  26. Shear M. The aggressive nature of the odontogenic keratocyst: Is it a benign cystic neoplasm? (Part 1). Oral Oncol. 2002;38:219
  27. Ahlfors E, Larsson A, Sjögren S. The odontogenic keratocyst: A benign cyst tumor?. J Oral Maxillofac Surg. 1984;42:10
  28. Dunoff RB, Harper E, Guralnick WC. Collagenolytic activity in keratocysts. J Oral Surg. 1972;30:879
  29. Meghji S, Harvey W, Harris M. Interleukin-like activity in cystic lesions of the jaw. Br J Oral Maxillofac Surg. 1989;27:1
  30. Megji S, Henderson B, Bando Y, et al. Interleukin-1: The principal osteolytic cytokine produced by keratocysts. Arch Oral Biol. 1992;37:935
  31. Li T, Browne RM, Matthews JB. Immunocytochemical expression of parathyroid hormone–related protein in odontogenic jaw cysts. Br J Oral Maxillofac Surg. 1997;35:275
  32. Piattelli A, Fioroni M, Rubini C. Differentiation of odontogenic keratocysts from other cysts by the expression of bcl-2 immunoreactivity. Oral Oncol. 1998;34:404
  33. Shear M. The aggressive nature of the odontogenic keratocyst: Is it a benign cystic neoplasm? (Part II). Oral Oncol. 2002;38:323
  34. Ninomiya T, Kubota Y, Koji T, et al. Marsupialization inhibits interleukin-1a expression and epithelial cell proliferation in odontogenic keratocysts. J Oral Pathol Med. 2002;31:526
  35. August M, Faquin WC, Troulis M, et al. Dedifferentiation of odontogenic keratocyst epithelium after cyst decompression. J Oral Maxillofac Surg. 2003;61:678

PII: S0278-2391(06)01443-1

doi: 10.1016/j.joms.2006.06.284

Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 4 , Pages 640-644 , April 2007

Article Tools