Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 3 , Pages 452-456 , March 2007

A Preliminary Comparative Study of the Prognostic Implications of Type 2 Diabetes Mellitus for Patients With Primary Gingival Carcinoma Treated With Surgery and Radiation Therapy

  • Márta Ujpál, DMD, PhD

      Affiliations

    • Reader, Department of Oral and Maxillofacial Surgery, Semmelweis University, Budapest, Hungary.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Ujpál: Department of Oral and Maxillofacial Surgery, Semmelweis University, H-1085 Budapest Maria u 52, Hungary
    • ,
  • József Barabás, MD, PhD

      Affiliations

    • Professor and Director, Department of Oral and Maxillofacial Surgery, Semmelweis University, Budapest, Hungary.
    • ,
  • Ilona Kovalszky, MD, DSC

      Affiliations

    • Professor, Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
    • ,
  • György Szabó, MD, DSC

      Affiliations

    • Professor, Department of Oral and Maxillofacial Surgery, Semmelweis University, Budapest, Hungary.
    • ,
  • Zsolt Németh, MD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Semmelweis University, Budapest, Hungary.
    • ,
  • Katalin Gábris, DMD, PhD

      Affiliations

    • Reader, Department of Pedodontics and Orthodontics, Semmelweis University, Budapest, Hungary.
    • ,
  • Zsuzsanna Suba, MD, PhD

      Affiliations

    • Professor, Department of Oral and Maxillofacial Surgery, Semmelweis University, Budapest, Hungary.

References 

  1. Richardson LC, Pollack LA. Therapy insight: Influence of type 2 diabetes on the development, treatment and outcomes of cancer. Nat Clin Pract Oncol. 2005;2:48
  2. Adami HO, Chow WH, Nyren O. Excess risk of primary liver cancer in patients with diabetes mellitus. J Natl Cancer Inst. 1996;88:1472
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  18. Mogyorosi A, Ziyadeh FN. GLUT1 and TGF-beta: The link between hyperglycaemia and diabetic nephropathy. Nephrol Dial Transplant. 1999;14:2827
  19. Oliver RJ, Woodwards RT, Sloan P. Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection: Results of EORTC Transplantational Research Fund studies. Eur J Cancer. 2004;40:503
  20. Kunkel M, Reichert TE, Benz P. Overexpression of Glut-1 and increased metabolism in tumors are associated with poor prognosis in patients with oral squamous cell carcinoma. Cancer. 2003;97:1015
  21. Rosenquist K, Wennerberg J, Schildt EB. Oral status, oral infections, and some lifestyle factors as risk factors for oral and oropharyngeal squamous cell carcinoma: A population-based case-control study in southern Sweden. Acta Otolaryngol. 2005;125:1327
  22. Hashibe M, Jacob BJ, Thomas G. Socioeconomic status, lifestyle factors and oral premalignant lesions. Oral Oncol. 2003;39:664
  23. Altomare E, Vendemiale G, Chicco D. Increased lipid peroxidation in type 2 poorly controlled diabetic patient. Diabetes Metab. 1992;18:264
  24. Riu L, Aguirre V, Kim JK. Insulin/IGF-1 and TNF-alpha stimulates phosporilation of IRS-1 at inhibitory Ser 307 via distinct pathways. J Clin Invest. 2001;107:181
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PII: S0278-2391(06)01796-4

doi: 10.1016/j.joms.2006.09.015

Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 3 , Pages 452-456 , March 2007

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