Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 11 , Pages 2218-2226 , November 2007

Effect of Submucosal Injection of Dexamethasone on Postoperative Discomfort After Third Molar Surgery: A Prospective Study

  • Giovanni Battista Grossi, DMD, DDS, MD

      Affiliations

    • Clinical Assistant Professor, Department of Oral Surgery, School of Dentistry, University of Milan, Milan, Italy.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Grossi: Department of Oral Surgery, School of Dentistry, Istituti Clinici di Perfezionamento, Via Commenda no. 10, Milano 20122, Italy
    • ,
  • Carlo Maiorana, DDS, MD

      Affiliations

    • Associate Professor, Department of Oral Surgery, School of Dentistry, University of Milan, Milan, Italy.
    • ,
  • Rocco Alberto Garramone, DDS, MD

      Affiliations

    • Resident, Department of Oral Surgery, School of Dentistry, University of Milan, Milan, Italy.
    • ,
  • Andrea Borgonovo, DMD, MD

      Affiliations

    • Resident, Department of Oral Surgery, School of Dentistry, University of Milan, Milan, Italy.
    • ,
  • Mario Beretta, DDS

      Affiliations

    • Resident, Department of Oral Surgery, School of Dentistry, University of Milan, Milan, Italy.
    • ,
  • Davide Farronato, DDS

      Affiliations

    • Resident, Department of Oral Surgery, School of Dentistry, University of Milan, Milan, Italy.
    • ,
  • Franco Santoro, DDS, MD

      Affiliations

    • Department Head, Department of Oral Surgery, School of Dentistry, University of Milan, Milan, Italy.

References 

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  2. Savin J, Ogden GR. Third molar surgery—A preliminary report on aspects affecting quality of life in the early postoperative period. Br J Oral Maxillofac Surg. 1997;35:246
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  5. Troullos ES, Hargreaves KM, Butler DP, et al. Comparison of non-steroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone for acute pain, swelling and trismus. J Oral Maxillofac Surg. 1990;48:945
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  11. Ruta DA, Bissias E, Ogston S, et al. Assessing health outcomes after extraction of third molars: The postoperative symptom severity (PoSSe) scale. Br J Oral Maxillofac Surg. 2000;38:480
  12. Fisher SE, Frame JW, Route PGJ. Factors affecting the onset and severity of pain following the surgical removal of unilateral impacted mandibular third molar teeth. Br Dent J. 1988;164:351
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  14. Montgomery MT, Hogg JP, Roberts DL, et al. The use of glucocorticosteroids to lessen the inflammatory sequelae following third molar surgery. J Oral Maxillofac Surg. 1990;48:179
  15. Peterson LJ. Principles of Management of Impacted Teeth. In: Principles of Oral and Maxillofacial Surgery. vol 1:Philadelphia, PA: JB Lippincott; 1992;p. 117
  16. Skjelbred P, Lokken P. Post-operative pain and inflammatory reaction reduced by injection of a corticosteroid (A controlled trial in bilateral oral surgery). Eur J Clin Pharmacol. 1982;21:391
  17. Pedersen A. Decadronphosphate in the relief of complaints after third molar surgery. Int J Oral Maxillofac Surg. 1985;14:235
  18. Messer EJ, Keller JJ. The use of intraoral dexamethasone after extraction of mandibular third molar. Oral Surg Oral Med Oral Pathol. 1975;40:594
  19. Neupert EA, Lee JW, Philput CB, et al. Evaluation of dexamethasone for reduction of postsurgical sequelae of third molar removal. J Oral Maxillofac Surg. 1992;50:1177
  20. Milles M, Desjardins PJ. Reduction of postoperative facial swelling by low-dose methylprednisolone. J Oral Maxillofac Surg. 1993;51:987
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  22. Schmelzeisen R, Frolich JC. Prevention of postoperative swelling and pain by dexamethasone after operative removal of impacted third molar teeth. Eur J Clin Pharmacol. 1993;44:275
  23. Dionne RA, Gordon SM, Rowan J, et al. Dexamethasone suppresses peripheral prostanoid levels without analgesia in a clinical model of acute inflammation. J Oral Maxillofac Surg. 2003;61:997
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  25. Beirne OR, Hollander B. The effect of methylprednisolone on pain, trismus, and swelling after removal of third molars. Oral Surg Oral Med Oral Pathol. 1986;61:134
  26. Baxendale BR, Vater M, Lavery KM. Dexamethasone reduces pain and swelling following extraction of third molar teeth. Anaesthesia. 1993;48:961
  27. Moore PA, Brar P, Smiga ER, et al. Preemptive rofecoxib and dexamethasone for prevention of pain and trismus following third molar surgery. Oral Surg Oral Med Oral Pathol. 2005;99:E1
  28. Insel PA. Analgesic-antipyretics and antiinflammatory agents (Drugs employed in the treatment of rheumatoid arthritis and gout). In:  Gilman AG,  Rall TW,  Nies AS, et al. editor. Goodman and Gilman’s the Pharmacological Basis of Therapeutics. ed 8. New York, NY: Pergamon Press; 1990;p. 638–681
  29. Beirne OR. Evaluation of dexamethasone for reduction of postsurgical sequelae of third molar removal (Discussion). J Oral Maxillofac Surg. 1992;50:1182

PII: S0278-2391(06)02205-1

doi: 10.1016/j.joms.2006.11.036

Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 11 , Pages 2218-2226 , November 2007

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