Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 7 , Pages 1328-1331 , July 2007

Incidence of Osteonecrosis of the Jaw in Patients With Multiple Myeloma and Breast or Prostate Cancer on Intravenous Bisphosphonate Therapy

This paper was presented in part at the 88th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons, October 4, 2006, San Diego, CA.

  • Estee P. Wang

      Affiliations

    • Student, Harvard School of Dental Medicine, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, the Department of Medicine, Beth Israel Deaconess Medical Center, Harvard School of Dental Medicine and Harvard Medical School, Boston, MA.
    • ,
  • Leonard B. Kaban, DMD, MD

      Affiliations

    • W.C. Guralnick Professor and Chairman, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, the Department of Medicine, Beth Israel Deaconess Medical Center, Harvard School of Dental Medicine and Harvard Medical School, Boston, MA.
    • ,
  • Gordon J. Strewler, MD

      Affiliations

    • Professor of Medicine, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, the Department of Medicine, Beth Israel Deaconess Medical Center, Harvard School of Dental Medicine and Harvard Medical School, Boston, MA.
    • ,
  • Noopur Raje, MD

      Affiliations

    • Assistant Professor of Medicine, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, the Department of Medicine, Beth Israel Deaconess Medical Center, Harvard School of Dental Medicine and Harvard Medical School, Boston, MA.
    • ,
  • Maria J. Troulis, DDS, MSc

      Affiliations

    • Associate Professor of OMFS, Director of Residency Training Program, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, the Department of Medicine, Beth Israel Deaconess Medical Center, Harvard School of Dental Medicine and Harvard Medical School, Boston, MA.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Troulis: Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Warren Building, 55 Fruit Street, Suite 1201, Boston, MA 02114

References 

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  2. Kuehn BM. Reports of adverse events from bone drugs prompt caution. JAMA. 2006;295:2833
  3. Bamias A, Kastritis E, Bamia C, et al. Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: Incidence and risk factors. J Oral Maxillofac Surg. 2006;64:995
  4. Sanna G, Preda L, Bruschini R, et al. Bisphosphonates and jaw osteonecrosis in patients with advanced breast cancer. Ann Oncol. 2006;17:1512
  5. Zervas K, Verrou E, Teleioudis Z, et al. Incidence, risk factors and management of osteonecrosis of the jaw in patients with multiple myeloma: A single-centre experience in 303 patients. Br J Haematol. 2006;134:620
  6. Dimopoulos MA, Kastritis E, Anagnostopoulos A, et al. Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: Evidence of increased risk after treatment with zoledronic acid. Haematologica. 2006;91:968
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  12. Strewler GJ, Long-term bisphosphonates for osteoporosis: An introduction. Available at: BoneKEy-Osteovision 2:6-9 http://www.bonekey-ibms.org/cgi/content/full/ibmske. Accessed February 1, 2005
  13. Reid IR, Brown JP, Burckhardt P, et al. Intravenous zoledronic acid in postmenopausal women with low bone mineral density. N Engl J Med. 2002;346:653
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  15. Katz H. Endodontic implications of bisphosphonate-associated osteonecrosis of the jaws: A report of three cases. J Endod. 2005;31:831
  16. Ficarra G, Beninati F, Rubino I, et al. Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonate treatment. J Clin Periodontol. 2005;32:1123
  17. Vannucchi AM, Ficarra G, Antonioli E, Bosi A. Osteonecrosis of the jaw associated with zoledronate therapy in a patient with multiple myeloma. Br J Haematol. 2005;128:738
  18. Bagan JV, Murillo J, Jimenez Y, et al. Avascular jaw osteonecrosis in association with cancer chemotherapy: Series of 10 cases. J Oral Pathol Med. 2005;34:120
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 This study was funded in part by the American Association of Oral and Maxillofacial Surgeons Student Training Award; Office of Enrichment Programs, Harvard Medical School; and the Department of Oral and Maxillofacial Education and Research Fund.

PII: S0278-2391(07)00328-X

doi: 10.1016/j.joms.2007.03.006

Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 7 , Pages 1328-1331 , July 2007

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