Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 11 , Pages 2349-2355 , November 2008

Chondrosarcoma of the Jaw: A Closer Look at its Management

  • Gilberto Sammartino, MD

      Affiliations

    • Associate Professor, Odontostomatological and Maxillofacial Sciences, University “Federico II” of Naples, Naples, Italy
    • ,
  • Gaetano Marenzi, DDS

      Affiliations

    • Attending Physician, Department of Odontostomatological and Maxillofacial Sciences, University “Federico II” of Naples, Naples, Italy
    • ,
  • Candace M. Howard, MD, PhD

      Affiliations

    • Assistant Professor, Department of Biochemistry and Microbiology, and Department of Orthopedics, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV
    • ,
  • Corrado Minimo, MD

      Affiliations

    • Assistant Professor, Department of Pathology, Main Line Clinical Laboratories, Wynnewood, PA
    • ,
  • O. Trosino, DDS

      Affiliations

    • Student, Department of Odontostomatological and Maxillofacial Sciences, University “Federico II” of Naples, Naples, Italy
    • ,
  • Luigi Califano, MD

      Affiliations

    • Professor, Department of Odontostomatological and Maxillofacial Sciences, University “Federico II” of Naples, Naples, Italy
    • ,
  • Pier Paolo Claudio, MD, PhD

      Affiliations

    • Professor, Department of Biochemistry and Microbiology, and Department of Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Claudio: Department of Biochemistry and Microbiology and Department of Surgery, Joan C. Edwards School of Medicine, Marshall University, One John Marshall Dr, Rm 336Q, Huntington, WV 25755

References 

  1. Bertoni F, Bacchini P, Hogendoorn P. Chondrosarcoma. In: World Health Organization Classification of Tumors (Pathology and Genetics of Tumors of Soft Tissue and Bone). (ed. Press, I.). 2002;p. 247–258Lyon
  2. Schajowicz F. Tumors and Tumorlike Lesions of Bone and Joints. New York: Springer-Verlag; 1981;
  3. Mark RJ, Tran LM, Sercarz J, et al. Chondrosarcoma of the head and neck (The UCLA experience, 1955-1988). Am J Clin Oncol. 1993;16:232
  4. Bovee JV, Cleton-Jansen AM, Taminiau AH, et al. Emerging pathways in the development of chondrosarcoma of bone and implications for targeted treatment. Lancet Oncol. 2005;6:599
  5. Huvos AG, Marcove RC. Chondrosarcoma in the young (A clinicopathologic analysis of 79 patients younger than 21 years of age). Am J Surg Pathol. 1987;11:930
  6. Ruark DS, Schlehaider UK, Shah JPM. Chondrosarcomas of the head and neck. World J Surg. 1992;16:1010;discussion 1015
  7. Webber PA, Hussain SS, Radcliffe GJ. Cartilaginous neoplasms of the head and neck (A report on four cases). J Laryngol Otol. 1986;100:615
  8. Finn DG, Goepfert H, Batsakis JG. Chondrosarcoma of the head and neck. Laryngoscope. 1984;94:1539
  9. Ajagbe HA, Daramola JO, Junaid TA. Chondrosarcoma of the jaw: Review of fourteen cases. J Oral Maxillofac Surg. 1985;43:763
  10. Chaudhry AP, Robinovitch MR, Mitchell DF, et al. Chondrogenic tumors of the jaws. Am J Surg. 1961;102:403
  11. Gorsky M, Epstein JB. Craniofacial osseous and chondromatous sarcomas in British Columbia--A review of 34 cases. Oral Oncol. 2000;36:27
  12. Aziz SR, Miremadi AR, McCabe JC. Mesenchymal chondrosarcoma of the maxilla with diffuse metastasis: Case report and literature review. J Oral Maxillofac Surg. 2002;60:931
  13. Veth R, Schreuder B, van Beem H, et al. Cryosurgery in aggressive, benign, and low-grade malignant bone tumors. Lancet Oncol. 2005;6:25
  14. Crawford JG, Oda D, Egbert M, et al. Mesenchymal chondrosarcoma of the maxilla in a child. J Oral Maxillofac Surg. 1995;53:938
  15. Harwood AR, Krajbich JI, Fornasier VL. Radiotherapy of chondrosarcoma of bone. Cancer. 1980;45:2769
  16. Garrington GE, Collett WK. Chondrosarcoma (I. A selected literature review). J Oral Pathol. 1988;17:1
  17. Potdar GG. Chondrosarcoma. Indian J Cancer. 1970;7:280
  18. Sato K, Nukaga H, Horikoshi T. Chondrosarcoma of the jaws and facial skeleton: A review of the Japanese literature. J Oral Surg. 1977;35:892
  19. Paddison GM, Hanks GE. Chondrosarcoma of the maxilla (Report of a case responding to supervoltage irradiation and review of the literature). Cancer. 1971;28:616
  20. Batsakis JG. Tumors of the Head and Neck. Baltimore: Williams & Wilkins; 1979;
  21. Bhaskar SN. Synopsis of Oral Pathology. St. Louis: CV Mosby; 1980;
  22. Pindborg JJ. The incidence rate of jaw sarcomas in Denmark, 1943 to 1953. Oral Surg Oral Med Oral Pathol. 1961;14:276
  23. Harris M. The enigmatic chondrosarcoma of the maxilla. Oral Surg Oral Med Oral Pathol. 1972;34:13
  24. Terezhalmy GT, Bottomley WK. Maxillary chondrogenic sarcoma: Management of a case. Oral Surg Oral Med Oral Pathol. 1977;44:539
  25. Kragh LV, Dahlin DC, Erich JB. Cartilaginous tumors of the jaws and facial regions. Am J Surg. 1960;99:852
  26. Reychler H. Cartilaginous tumors of the jaw. [in French] Rev Stomatol Chir Maxillofac. 1988;89:321
  27. Zachariades N, Vairaktaris E, Mezitis M, et al. Chondrosarcoma of the orofacial region (Review of the literature and report of two cases). Rev Stomatol Chir Maxillofac. 1987;88:382
  28. Bates GJEM, Herdman RCD. Chondrosarcoma of the sphenoid (A case report and review). J Laryngol Otol. 1998;102:727
  29. Hackney FL, Aragon SB, Aufdemorte TB, et al. Chondrosarcoma of the jaws: Clinical findings, histopathology, and treatment. Oral Surg Oral Med Oral Pathol. 1991;71:139
  30. Hertzanu Y, Mendelsohn DB, Davidge-Pitts K, et al. Chondrosarcoma of the head and neck--the value of computed tomography. J Surg Oncol. 1985;28:97
  31. Huvos AG. Bone Tumors. Philadelphia: Saunders; 1979;
  32. Piattelli A, Favia GF. Periosteal osteosarcoma of the jaws: Report of 2 cases. J Periodontol. 2000;71:325
  33. Saito K, Unni KK, Wollan PC, et al. Chondrosarcoma of the jaw and facial bones. Cancer. 1995;76:1550
  34. Harnsberger HR, Dillon WP. Imaging tumors of the central nervous system and extracranial head and neck. CA Cancer J Clin. 1987;37:225
  35. Edeiken J, Karasick D. Imaging in bone cancer. CA Cancer J Clin. 1987;37:239
  36. Unni KK, Inwards CY, Bridge JA, et al. Chondrosarcoma. In: AFIP Atlas of Tumor Pathology; 4th Series, Fascicle 2: Tumors of the Bones and Joints. Washington DC: American Registry of Pathology; 2005;p. 73–118
  37. Bakotic B, Huvos AG. Tumors of the bones of the feet: The clinicopathologic features of 150 cases. J Foot Ankle Surg. 2001;40:277
  38. Bjornsson J, McLeod RA, Unni KK, et al. Primary chondrosarcoma of long bones and limb girdles. Cancer. 1998;83:2105
  39. Anderson W. Pathology. St. Louis: CV Mosby; 1971;
  40. Sawyer DR, Nwoku AL, Kekere-Ekun AT. Chondrosarcoma of the jaws (Report of two cases). J Oral Med. 1987;42:30
  41. Anil S, Beena VT, Lal PM, et al. Chondrosarcoma of the maxilla (Case report). Aust Dent J. 1998;43:172
  42. Garrington GE, Collett WK. Chondrosarcoma (II. Chondrosarcoma of the jaws: Analysis of 37 cases). J Oral Pathol. 1988;17:12
  43. Molla MR, Ijuhin N, Sugata T, et al. Chondrosarcoma of the jaw: Report of two cases. J Oral Maxillofac Surg. 1987;45:453
  44. Oujilal A, el Alami MN, Lazrak A, et al. Chondrosarcoma of the jaw (A case localized to the mandible). [in French] Rev Stomatol Chir Maxillofac. 2001;102:115
  45. Burkey BB, Hoffman HT, Baker SR, et al. Chondrosarcoma of the head and neck. Laryngoscope. 1990;100:1301
  46. Carlson ER, Panella T, Holmes JD. Sarcoma of mandible. J Oral Maxillofac Surg. 2004;62:81
  47. Penel N, Van Haverbeke C, Lartigau E, et al. Head and neck soft tissue sarcomas of adult: Prognostic value of surgery in multimodal therapeutic approach. Oral Oncol. 2004;40:890
  48. Bickels J, Meller I, Shmookler BM, et al. The role and biology of cryosurgery in the treatment of bone tumors (A review). Acta Orthop Scand. 1999;70:308
  49. Marcove RC, Stovell PB, Huvos AG, et al. The use of cryosurgery in the treatment of low and medium grade chondrosarcoma (A preliminary report). Clin Orthop Relat Res. 1977;147:
  50. Merrill RG, Yih WY, Shamloo J. Synovial chondrosarcoma of the temporomandibular joint: A case report. J Oral Maxillofac Surg. 1997;55:1312
  51. Ariyoshi Y, Shimahara M. Mesenchymal chondrosarcoma of the maxilla: Report of a case. J Oral Maxillofac Surg. 1999;57:733
  52. Reichardt P, Dorken B. The role of polychemotherapy in the management of malignant bone tumors. [in German] Chirurg. 2002;73:1170
  53. Mitchell AD, Ayoub K, Mangham DC, et al. Experience in the treatment of dedifferentiated chondrosarcoma. J Bone Joint Surg Br. 2000;82:55
  54. Dickey ID, Rose PS, Fuchs B, et al. Dedifferentiated chondrosarcoma: The role of chemotherapy with updated outcomes. J Bone Joint Surg Am. 2004;86-A:2412
  55. Cleton-Jansen AM, van Beerendonk HM, Baelde HJ, et al. Estrogen signaling is active in cartilaginous tumors: Implications for antiestrogen therapy as treatment option of metastasized or irresectable chondrosarcoma. Clin Cancer Res. 2005;11:8028
  56. Morioka H, Weissbach L, Vogel T, et al. Antiangiogenesis treatment combined with chemotherapy produces chondrosarcoma necrosis. Clin Cancer Res. 2003;9:1211
  57. Kim R, Emi M, Tanabe K, et al. Therapeutic potential of antisense Bcl-2 as a chemosensitizer for cancer therapy. Cancer. 2004;101:2491

PII: S0278-2391(07)00386-2

doi: 10.1016/j.joms.2006.05.069

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 11 , Pages 2349-2355 , November 2008

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