Effect of Chemotherapy on Primary Mucosa-Associated Lymphoid Tissue Lymphoma of the Orbit

Dimitrakopoulos, Ioannis; Venetis, Grigorios; Kaloutsi, Vasiliki; Sotiropoulos, Damianos; Papadimitriou, Constantinos

doi:10.1016/j.joms.2007.04.018

« Previous Next »Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 1 , Pages 16-20, January 2008

Effect of Chemotherapy on Primary Mucosa-Associated Lymphoid Tissue Lymphoma of the Orbit

Ioannis Dimitrakopoulos, MD, DDS
- Associate Professor, University Clinic of Oral and Maxillofacial Surgery, “G. Papanikolaou” General Hospital, Thessaloniki, Greece.
- Address correspondence and reprint requests to Dr Dimitrakopoulos: P Mela 28, 546 22, Thessaloniki, Greece
Grigorios Venetis, MD, DDS
- Lecturer, University Clinic of Oral and Maxillofacial Surgery, “G. Papanikolaou” General Hospital, Thessaloniki, Greece.
Vasiliki Kaloutsi, MD
- Associate Professor, Department of Pathology, School of Medicine, Aristotle University, Thessaloniki, Greece.
Damianos Sotiropoulos, MD
- Pathologist, Department of Hematology and Bone Marrow Transplantation Unit, “G. Papanikolaou” General Hospital, Thessaloniki, Greece.
Constantinos Papadimitriou, MD
- Professor and Head, Department of Pathology, School of Medicine, Aristotle University, Thessaloniki, Greece.

Purpose

To present a treatment plan for localized mucosa-associated lymphoid tissue lymphoma of the orbit in order to preserve vital structures and function from the side effects of radiotherapy.

Materials and Methods

Study of 2 clinical cases by means of clinical and radiologic examination, with 2 and 3 years follow-up, respectively.

Results

Immediate remission of the disease after 6 cycles of chemotherapy, with no signs of recurrence after 2 and 3 years. Clinical examination of the oculomotor mechanism and visual activity gave excellent results.

Conclusion

Although radiotherapy is preferable for localized lymphoproliferative lesions, chemotherapy should also be considered as an effective treatment that preserves the integrity and function of the ocular adnexa.