Osteoconductive Effects of 3 Heat-Treated Hydroxyapatites in Rabbit Calvarial Defects
Presented at the 17th International Conference on Oral and Maxillofacial Surgery, Vienna, Austria, September 2005.
Purpose
This study aimed to detect the osteoconductive ability of 3 bovine hydroxyapatites (HAs) that were sintered at 800°C (HA800), 1,200°C (HA1200), and 1,350°C (HA1350), according to new bone formation.
Material and Methods
Two bicortical skull defects were prepared in 10 New Zealand white rabbits. Four rabbits were used as controls; in each, 1 defect was filled with autogenous bone chips and the contralateral defect was left empty for the critical size defect (CSD). The other 6 rabbits had a total of 12 defects, 4 each randomly filled with HA 800, HA1200, or HA1350. The animals were sacrificed at 8 weeks. New bone formation was assessed by radiographic densitometry and histomorphometric analysis.
Results
The mean optical density (OD) of the CSD group (0.092 ± 0.006) was less than that of the autogenous bone chip (0.102 ± 0.002), HA1200 (0.108 ± 0.005), and HA 1350 (0.102 ± 0.003) groups. The mean OD of the HA 1200 group was significantly different from that of the HA 800 group (0.094 ± 0.003). The histomorphometric analysis demonstrated that the autogenous bone chip group (34.89 ± 4.61) was significantly different from the CSD (12.16± 6.97), HA 800 (18.32 ± 7.33), and HA1350 (13.99 ± 3.94) groups, but not the HA1200 group (24.83 ± 12.12).
Conclusions
The findings demonstrate that heat-treated bovine HA enhances bone formation, and HA 1200 tends to provide greater bone formation than the other 2 HAs.
⁎Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkla, Thailand.
†Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkla, Thailand.
‡Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkla, Thailand.
§Lecturer, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand.
Address correspondence and reprint requests to Dr Pripatnanont: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkla, Thailand 90112
Supported by the National Metal and Materials Technology Center, National Science and Technology Development Agency of Thailand.
ABSTRACT