Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 2 , Pages 286-290 , February 2008

Hyaluronidase Increases the Duration of Mepivacaine in Inferior Alveolar Nerve Blocks

  • Anna Carolina Ratto Tempestini Horliana, MDS

      Affiliations

    • Masters Degree Student, Integrated Dental Clinic, Department of Estomatology, College of Dentistry, University of São Paulo, São Paulo, Brazil.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Tempestini Horliana: Faculdade de Odontologia da Universidade de São Paulo, Av Professor Lineu Prestes, 2227, Cidade Universitária, 05508-900 São Paulo, Brazil
    • ,
  • Mayara Aguilar Dias de Brito, DDS

      Affiliations

    • Investigator, Integrated Dental Clinic, Department of Estomatology, College of Dentistry, University of São Paulo, São Paulo, Brazil.
    • ,
  • Flávio Eduardo Guillin Perez, PhD

      Affiliations

    • Professor, Integrated Dental Clinic, Department of Estomatology, College of Dentistry, University of São Paulo, São Paulo, Brazil.
    • ,
  • Maria Prazeres Barbalho Simonetti, PhD

      Affiliations

    • Professor, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
    • ,
  • Rodney Garcia Rocha, PhD

      Affiliations

    • Professor and Chairman, Integrated Dental Clinic, Department of Estomatology, College of Dentistry, University of São Paulo, São Paulo, Brazil.
    • ,
  • Maria Aparecida Borsatti, PhD

      Affiliations

    • Professor, Integrated Dental Clinic, Department of Estomatology, College of Dentistry, University of São Paulo, São Paulo, Brazil.

References 

  1. Malamed SF. Handbook of Local Anesthesia. 4th Ed.. St Louis, MO: Mosby; 1997;
  2. Watson D. Hyaluronidase. Br J Anaesth. 1993;71:422
  3. Hynes WL, Walton SL. Hyaluronidases of gram-positive bacteria. FEMS Microbiol Lett. 2000;183:201
  4. Hajjaji HE, Cole AA, Manicourt DH. Chondrocytes, synoviocytes and dermal fibroblasts all express PH-20, a hyaluronidase active at neutral pH. Arthritis Res Ther. 2005;7:R756
  5. Sarvela J, Nikki P. Hyaluronidase improves regional ophthalmic anaesthesia with etidocaine. Can J Anaesth. 1992;39:920
  6. Kallio H, Paloheimo M, Maunuksela EL. Hyaluronidase as an adjuvant in bupivacaine-lidocaine mixture for retrobulbar/peribulbar block. Anesth Analg. 2000;91:934
  7. Nicoll JM, Treuren B, Acharya PA, et al. Retrobulbar anaesthesia: The role of hyaluronidase. Anesth Analg. 1986;65:1324
  8. Dempsey GA, Barrett PJ, Kirby IJ. Hyaluronidase and peribulbar block. Br J Anaesth. 1997;78:671
  9. Ridenour S, Reader A, Beck M, et al. Anesthetic efficacy of a combination of hyaluronidase and lidocaine with epinephrine in inferior alveolar nerve blocks. Anesth Prog. 2001;48:9
  10. Popitz-Bergez FA, Leeson S, Strichartz GR, et al. Relation between functional deficit and intraneural local anesthetic during peripheral nerve block. Anesthesiology. 1995;83:583
  11. Naftalin LW, Yagiela JA. Vasoconstrictors: Indications and precautions. Dent Clin North Am. 2002;46:733
  12. Lipp MDW. Local Anesthesia in Dentistry. Chicago, IL: Quintessence; 1993;
  13. Jastak JT, Yagiela JA. Vasoconstrictor and local anaesthesia: A review and rationale for use. J Am Dent Assoc. 1983;107:623
  14. Quhill F, Bowling B, Packard RB. Hyaluronidase allergy after peribulbar anesthesia with orbital inflammation. J Cataract Refract Surg. 2004;30:916
  15. Salmen S. Inhibitors of Bacterial and Mammalian Hyaluronidases: Synthesis and Structure-Activity Relationships. Regensburg: University of Regensburg; 2003;

 This study was funded by grants from CAPES/Brazil.

PII: S0278-2391(07)01419-X

doi: 10.1016/j.joms.2007.06.628

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 2 , Pages 286-290 , February 2008

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