Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 12 , Pages 2470-2474 , December 2007

Osteoformin Accelerates Fresh Fracture Healing in Rats

  • Lian Xiang Bi, MD

      Affiliations

    • Assistant Professor, Department of Orthopaedic Surgery and Rehabilitation, and the Department of Surgery, Division of Oral and Maxillofacial Surgery, The University of Texas Medical Branch, Galveston, TX.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Bi: Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0174
  • ,
  • Elgene G. Mainous, DDS

      Affiliations

    • Professor and Chief, Department of Surgery, Division of Oral and Maxillofacial Surgery, The University of Texas Medical Branch, Galveston, TX.
  • ,
  • YaPing Zeng, BS

      Affiliations

    • Research Associate, Department of Orthopaedic Surgery and Rehabilitation, The University of Texas Medical Branch, Galveston, TX.
  • ,
  • William L. Buford Jr, PhD

      Affiliations

    • Professor and Director, Clinical Biomechanics Lab, Department of Orthopaedic Surgery and Rehabilitation, The University of Texas Medical Branch, Galveston, TX.

References 

  1. Bi LX, Simmons DJ, Yang J, et al. The effect of charged resins on the repair of a maxillary bone defects in the rabbit. J Bone Miner Res. 2000;15(suppl 1):S235
  2. Simmons DJ, Krukowski M, Bi LX, et al. Positive and negative-ion exchange resin: Disparate effects on hard tissue repair. Adv Bioeng. 1997;36:225
  3. Krukowski M, Simmons DJ, Summerfield A, et al. Charged beads: Generation of bone and giant cells. J Bone Miner Res. 1998;3:165
  4. Krukowski M, Shively RA, Osdoby P, et al. Stimulation of craniofacial and intramedullary bone formation by negatively charged beads. J Oral Maxillofac Surg. 1990;48:468
  5. Snyders RV, Eppley BL, Krukowski M, et al. Enhancement of repair in experimental calvarial bone defects using calcium sulfate and dextran beads. J Oral Maxillofac Surg. 1993;51:517
  6. Krukowski M, Snyders RV, Eppley BL, et al. Negatively charged resins stimulate bone formation in subperiosteal sites in rats (The effect of age). Clin Orthop. 1994;298:266
  7. Salman NN, Park JB. The effect of direct electrical current stimulation on the bone/porous metallic implant interface. Biomaterials. 1980;1:209
  8. Jacobs RR, Luethi U, Dueland RT, et al. Electrical stimulation of experimental nonunions. Clin Orthop. 1981;161:146
  9. Wittbjer J, Glantz PO, Rohlin M, et al. On direct currents and bone formation in demineralized bone transplants. Acta Odontol Scand. 1984;42:141
  10. Esterhai JL, Friedenberg ZB, Brighton CT, et al. Temporal course of bone formation in response to constant direct current stimulation. J Orthop Res. 1985;3:137
  11. Ferrier J, Ross SM, Kanehisa J, et al. Osteoclasts and osteoblasts migrate in opposite directions in response to a constant electrical field. J Cell Physiol. 1986;129:283
  12. Nerubay J, Marganit B, Bubis JJ, et al. Stimulation of bone formation by electrical current on spinal fusion. Spine. 1986;11:167
  13. Shimizu T, Zerwekh JE, Videman T, et al. Bone ingrowth into porous calcium phosphate ceramics: Influence of pulsing electromagnetic field. J Orthop Res. 1988;6:248
  14. Goh JC, Bose K, Kang YK, et al. Effects of electrical stimulation on the biomechanical properties of fracture healing in rabbits. Clin Orthop. 1988;233:268
  15. Rubin CT, McLeod KJ, Lanyon LE. Prevention of osteoporosis by pulsed electromagnetic fields. J Bone Joint Surg. 1989;71:411
  16. van Roermund PM, Hoekstra A, Visser WJ, et al. Effect of direct current stimulation on bone growth after distraction epiphysiolysis of the rabbit tibia. J Orthop Res. 1990;8:769
  17. Lew D, Marino A. The effect of electrical stimulation on bone formation around hydroxyapatite implants placed on the rabbit mandible. J Oral Maxillofac Surg. 1991;49:735
  18. Spadaro JA, Albanese SA, Chase SE. Bone formation near direct current electrodes with and without motion. J Orthop Res. 1992;10:729
  19. Ciombor DM, Aaron RK. Influence of electromagnetic fields on endochondral bone formation. J Cell Biochem. 1993;52:37
  20. Rubin CT, Donahue HJ, Rubin JE, et al. Optimization of electric field parameters for the control of bone remodeling: Exploitation of an indigenous mechanism for the prevention of osteopenia. J Bone Miner Res. 1993;8(suppl 2):S573
  21. Yonemori K, Matsunaga S, Ishidou Y, et al. Early effects of electrical stimulation on osteogenesis. Bone. 1996;19:173
  22. Narkhede PR. A histologic evaluation of the effect of electrical stimulation on osteogenic changes following placement of blade-vent implants in the mandible of rabbits. J Oral Implantol. 1998;24:185
  23. Hagiwara T, Bell WH. Effect of electrical stimulation on mandibular distraction osteogenesis. J Craniomaxillofac Surg. 2000;28:12
  24. Matsumoto H, Ochi M, Abiko Y, et al. Pulsed electromagnetic fields promote bone formation around dental implants inserted into the femur of rabbits. Clin Oral Implants Res. 2000;11:354
  25. Abeed RI, Naseer M, Abel EW. Capacitively coupled electrical stimulation treatment: Results from patients with failed long bone fracture unions. J Orthop Trauma. 1998;12:510
  26. Albert SF, Wong E. Electrical stimulation of bone repair. Clin Podiatr Med Surg. 1991;8:923
  27. Brighton CT, Black J, Friedenberg ZB, et al. A multicenter study of the treatment of non-unions with constant direct current. J Bone Joint Surg Am. 1981;63:2
  28. Friedenberg ZB, Harlow MC, Brighton CT. Healing of nonunion of the medial malleolus by means of direct current (A case report). J Trauma. 1971;11:883
  29. Lavine LS, Lustrin I, Shamos MH. Treatment of congenital pseudarthrosis of the tibia with direct current. Clin Orthop. 1971;124:69
  30. Bi LX, Mainous E, Bahrani HM, et al. Osteoformin stimulates osteoblast differentiation. J Bone Miner Res. 2003;18(suppl 2):SUN133
  31. Bonnarens F, Einhorn TA. Production of a standard closed fracture in laboratory animal bone. J Orthop Res. 1984;2:97
  32. Rubinacci A, Tessari L. Correlation analysis between bone formation rate and bioelectric potential. Calcif Tissue Int. 1983;35:728
  33. Friedenberg ZB, Zemsky LM, Pollis RP, et al. The response of non-traumatized bone to direct current. J Bone Joint Surg Am. 1974;56:1023
  34. Celeste AJ, Jannazzi JA, Taylor RC, et al. Identification of new transforming growth factor beta family members present in bone-inducing protein purified from bovine bone. Pro Natl Acad Sci U S A. 1990;87:9843
  35. Bi LX, Li J, Ling ZF. Repair of the bone defect of tibia with rotated muscle flap reacted with bovine bone morphogenetic protein in sheep. Chin J Pediatr Surg. 1994;15:169
  36. Luyten FP, Cunningham NS, Reddi AH. Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation. J Bio Chem. 1989;264:13377
  37. Reddi AH, Huggins CB. Cyclic electricochemical inactivation and restoration of competence of bone matrix to transform fibroblasts. Proc Natl Acad Sci U S A. 1974;71:1648
  38. Eriksson C. Bone morphogenesis and surface charge. Clin Orthop. 1976;121:295
  39. Nakamura H, Hirata A, Tsuji T, et al. Immunolocalization of keratan sulfate proteoglycan in rat calvaria. Arch Histol Cytol. 2001;64:109

PII: S0278-2391(07)01423-1

doi: 10.1016/j.joms.2007.06.630

Journal of Oral and Maxillofacial Surgery
Volume 65, Issue 12 , Pages 2470-2474 , December 2007