Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 4 , Pages 711-717 , April 2008

Evaluation of Early Nerve Regeneration Using a Polymeric Membrane Functionalized With Nerve Growth Factor (NGF) After a Crush Lesion of the Rat Mental Nerve

  • Mathilde Savignat, DMD

      Affiliations

    • Lecturer, Faculté de Chirurgie Dentaire, place de Verdun, Université de Lille II, Lille, France; and Unité de Neurosciences et Physiologie Adaptatives, Laboratoire de Plasticité Neuromusculaire, Université des Sciences et Technologies de Lille, Cedex, France.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Savignat: Faculté de Chirurgie Dentaire, place de Verdun, 59000 Lille
  • ,
  • Constant Vodouhe, PhD

      Affiliations

    • Doctor, INSERM Unité 595, Faculté de Chirurgie Dentaire, Université Louis Pasteur, Strasbourg-Cedex, France.
  • ,
  • Alain Ackermann

      Affiliations

    • Technician, INSERM Unité 595, Faculté de Chirurgie Dentaire, Université Louis Pasteur, Strasbourg-Cedex, France.
  • ,
  • Youssef Haikel, DMD, PhD

      Affiliations

    • Professor, INSERM Unité 595, Faculté de Chirurgie Dentaire, Université Louis Pasteur, Strasbourg-Cedex, France.
  • ,
  • Philippe Lavalle, PhD

      Affiliations

    • Doctor, INSERM Unité 595, Faculté de Chirurgie Dentaire, Université Louis Pasteur, Strasbourg-Cedex, France.
  • ,
  • Philippe Libersa, DMD, PhD

      Affiliations

    • Professor, Faculté de Chirurgie Dentaire, Université de Lille II, Lille, France; and Unité de Neurosciences et Physiologie Adaptatives, Laboratoire de Plasticité Neuromusculaire, Université des Sciences et Technologies de Lille, Cedex, France; and Physiopathologie et thérapeutique des tissus calcifiés, Faculté de Chirurgie Dentaire, Université de Lille II, Lille, France.

References 

  1. Giuliani M, Lajolo C, Deli G, et al. Inferior alveolar nerve paresthesia caused by endodontic pathosis: A case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:670
  2. Hildebrand C, Fried K, Tuisku F, et al. Teeth and tooth nerves. Prog Neurobiol. 1995;45:165
  3. Loescher AR, Smith KG, Robinson PP. Nerve damage and third molar removal. Dent Update. 2003;30:375
  4. Sandstedt P, Sörensen S. Neurosensory disturbances of the trigeminal nerve: A long-term follow-up of traumatic injuries. J Oral Maxillofac Surg. 1995;53:498
  5. Bongenhielm U, Robinson PP. Spontaneous and mechanically evoked afferent activity originating from myelinated fibres in ferret inferior alveolar nerve neuromas. Pain. 1996;67:399
  6. Bongenhielm U, Nosrat CA, Nosrat I, et al. Expression of sodium channel SNS/PN3 and ankyrin(G) mRNAs in the trigeminal ganglion after inferior alveolar nerve injury in the rat. Exp Neurol. 2000;164:384
  7. Robinson PP. Observation on the recovery of sensation following inferior alveolar nerve injuries. Br J Oral Maxillofac Surg. 1988;26:177
  8. Robinson PP, Loescher AR, Yates JM, et al. Current management of damage to the inferior alveolar and lingual nerves as a result of removal of third molars. Br J Oral Maxillofac Surg. 2004;42:285
  9. Holland GR. Experimental trigeminal nerve injury. Crit Rev Oral Biol Med. 1996;7:237
  10. Robinson PP, Loescher AR, Smith KG. A prospective, quantitative study on the clinical outcome of lingual nerve repair. Br J Oral Maxillofacial Surg. 2000;38:255
  11. Sugimoto T, Takemura M, Sakai A, et al. Cell size analysis of trigeminal primary afferent neurons comprizing individual peripheral branches of the rat mandibular nerve. Exp Neurol. 1986;93:565
  12. Naftel JP, Richards LP, Pan M, et al. Course and composition of the nerves that supply the mandibular teeth of the rat. Anat Rec. 1999;256:433
  13. Chudler EH, Anderson LC, Byers MR. Trigeminal ganglion neuronal activity and glial fibrillary acidic protein immunoreactivity after inferior alveolar nerve crush in the adult rat. Pain. 1997;73:141
  14. Harper SJ, Buchman VL, Owen D. Denervation of the skin following section of the inferior alveolar nerve leads to increased NGF accumulation without change in NGF mRNA expression. Exp Neurol. 1999;155:327
  15. McMahon SB, Armanini MP, Ling LH, et al. Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. Neuron. 1994;12:1161
  16. Qian XB, Naftel JP. Effects of neonatal exposure to anti-nerve growth factor on the number and size distribution of trigeminal neurones projecting to the molar dental pulp in rats. Arch Oral Biol. 1996;41:359
  17. Boyd JG, Gordon T. Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Mol Neurobiol. 2003;27:277
  18. Buchman VL, Davies AM. Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons. Development. 1993;118:989
  19. Fried K, Nosrat C, Lillesaar C, et al. Molecular signaling and pulpal nerve development. Crit Rev Oral Biol Med. 2000;11:318
  20. Huang EJ, Wilkinson GA, Farinas I, et al. Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC. Development. 1999;126:2191
  21. Naftel JP, Qian XB, Bernanke JM. Effects of postnatal anti-nerve growth factor serum exposure on development of apical nerves of the rat molar. Brain Res Dev Brain Res. 1994;80:54
  22. Maniwa S, Iwata A, Hirata H, et al. Effects of neurotrophic factors on chemokinesis of Schwann cells in culture. Scand J Plast Recons. 2003;37:14
  23. Frostick SP, Yin Q, Kemp GJ. Schwann cells, neurotrophic factors, and peripheral nerve regeneration. Microsurg. 1998;18:397
  24. Vodouhe C, Schmittbuhl M, Boulmedais F, et al. Effect of functionalization of multilayered polyelectrolyte films on motoneuron growth. Biomaterials. 2005;26:545
  25. Windebank AJ, Poduslo JF. Neuronal growth factor produced by adult peripheral nerve after injury. Brain Res. 1988;385:197
  26. Oudega M, Hagg T. Nerve growth factor promotes regeneration of sensory axons into adult rat spinal cord. Exp Neurol. 1996;140:218
  27. Tezcaner A, Hicks D, Boulmedais F, et al. Polyelectrolyte multilayer films as substrate for photoreceptor cells. Biomacromolecules. 2006;7:86
  28. Berger RL, Byers MR, Calkins DF. Dental nerve regeneration in rats. I. Electrophysiological studies of molar sensory deficit and recovery. Pain. 1983;15:345
  29. Verze L, Paraninfo A, Viglietti-Panzica C, et al. Expression of neuropeptides and growth-associated protein 43 (GAP-43) in cutaneous and mucosal nerve structures of the adult rat lower lip after mental nerve section. Ann Anat. 2003;185:35
  30. Imai T, Atsumi Y, Matsumoto K, et al. Regeneration of periodontal Ruffini endings of rat lower incisors following nerve cross-anastomosis with mental nerve. Brain Res. 2003;992:20
  31. Chen YS, Wang-Bennett LT, Coker NJ. Facial nerve regeneration in the silicone chamber: The influence of nerve growth factor. Exp Neurol. 1989;103:52
  32. Eppley BL, Snyders RV, Winkelmann TM, et al. Efficacy of nerve growth factor in regeneration of the mandibular nerve: A preliminary report. J Oral Maxillofac Surg. 1991;49:61
  33. Rich KM, Luszczynski JR, Osborne PA, et al. Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury. J Neurocytol. 1987;16:261
  34. Rich KM, Alexander TD, Pryor JC, et al. Nerve growth factor enhances regeneration through silicone chambers. Exp Neurol. 1989;105:162
  35. Rosner BI, Siegel RA, Grosberg A, et al. Rational design of contact guiding, neurotrophic matrices for peripheral nerve regeneration. Ann Biomed Eng. 2003;31:1383
  36. Santos X, Rodrigo J, Hontanilla B, et al. Evaluation of peripheral nerve regeneration by nerve growth factor locally administered with a novel system. J Neurosci Methods. 1998;85:119
  37. Santos X, Rodrigo J, Hontanilla B, et al. Local administration of neurotrophic growth factor in subcutaneous silicon chambers enhances the regeneration of the sensory component of the rat sciatic nerve. Microsurgery. 1999;19:275
  38. Smith KG, Yates JM, Robinson PP. The effect of nerve growth factor on functional recovery after injury to the chorda tympani and lingual nerves. Brain Res. 2004;1020:62
  39. Ross SM, Sabri MI, Spencer PS. Isolation and partial characterization of plasmalemma from quiescent Schwann cells in denervated rat sciatic nerve. J Neurochem. 1983;41:222
  40. Lewin GR, Ritter AM, Mendell LM. Nerve growth factor-induced hyperalgesia in the neonatal and adult rat. J Neurosci. 1993;13:2136
  41. Stucky CL, Koltzenburg M, Schneider M, et al. Overexpression of nerve growth factor in skin selectively affects the survival and functional properties of nociceptors. J Neurosci. 1999;19:8509

PII: S0278-2391(07)01497-8

doi: 10.1016/j.joms.2007.06.654

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 4 , Pages 711-717 , April 2008