Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 4 , Pages 647-656 , April 2008

Reconstruction of Mandibular Segmental Defects Using the Guided-Bone Regeneration Technique With Polylactide Membranes and/or Autogenous Bone Graft: A Preliminary Study on the Influence of Membrane Permeability

  • Cassio E. Sverzut, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeirao Preto, University of São Paulo, São Paulo, Brazil.
    • ,
  • Paulo E.P. Faria, DDS

      Affiliations

    • Doctorate Fellow, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry of Aracatuba, University of the State of São Paulo, São Paulo, Brazil.
    • ,
  • Carolina M. Magdalena, BDS

      Affiliations

    • Public Dental Practice, Brasilia, Brazil.
    • ,
  • Alexandre E. Trivellato, DDS, PhD

      Affiliations

    • Senior Lecturer, Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeirao Preto, University of São Paulo, São Paulo, Brazil.
    • ,
  • Francisco V. Mello-Filho, MD, PhD

      Affiliations

    • Associate Professor, Department of Ophthalmology, Otolaryngology and Head and Neck Surgery, Faculty of Medicine of Ribeirao Preto, University of São Paulo, São Paulo, Brazil.
    • ,
  • Cleber A.J. Paccola, MD, PhD

      Affiliations

    • Professor, Department of Biomechanics, Medicine and Locomotor Apparatus Rehabilitation, Faculty of Medicine of Ribeirao Preto, University of São Paulo, São Paulo, Brazil.
    • ,
  • Sylwester Gogolewski, PhD

      Affiliations

    • Materials Engineer, AO-ASIF Research Institute, Davos, Switzerland.
    • ,
  • Luiz A. Salata, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeirao Preto, University of São Paulo, São Paulo, Brazil.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Salata: Departments of Oral & Maxillofacial Surgery and Periodontics, Faculty of Dentistry, University of São Paulo, Ave do Café s/n, Campus USP, 14040-904 Ribeirão Preto, São Paulo, Brazil

References 

  1. Klesper B, Wahn J, Koebke J. Comparisons of bone volumes and densities relating to osseointegrated implants in microvascularly reconstructed mandibles: A study of cadaveric radius and fibula bones. J Craniomaxillofac Surg. 2000;28:110
  2. Lee JH, Kim MJ, Choi WS, et al. Concomitant reconstruction of mandibular basal and alveolar bone with a free fibular flap. Int J Oral Maxillofac Surg. 2004;33:150
  3. Head C, Alam D, Sercarz JA, et al. Microvascular flap reconstruction of the mandible: A comparison of bone grafts and bridging plates for restoration of mandibular continuity. Otolaryngol Head Neck Surg. 2003;129:48
  4. Donos N, Kostopoulos L, Karring T. Augmentation of the rat jaw with autogeneic corticocancellous bone grafts and guided tissue regeneration. Clin Oral Implants Res. 2002;13:192
  5. Buser D, Dula K, Hirt HP, et al. Lateral ridge augmentation using autografts and barrier membranes: A clinical study with 40 partially edentulous patients. J Oral Maxillofac Surg. 1996;54:420
  6. Busenlechner D, Kantor M, Tangl S, et al. Alveolar ridge augmentation with a prototype trilayer membrane and various bone grafts: A histomorphometric study in baboons. Clin Oral Implants Res. 2005;16:220
  7. Donos N, Kostopoulos L, Tonetti M, et al. Long-term stability of autogenous bone grafts following combined application with guided bone regeneration. Clin Oral Implants Res. 2005;16:133
  8. Hollinger JO. Preliminary report on the osteogenic potential of a biodegradable copolymer of polyactide (PLA) and polyglycolide (PGA). J Biomed Mater Res. 1983;17:71
  9. Warrer K, Karring T, Nyman S, et al. Guided tissue regeneration using biodegradable membranes of polylactic acid or polyurethane. J Clin Periodontol. 1992;19:633
  10. Gogolewski S, Jovanovic M, Perren SM, et al. Tissue response and in vivo degradation of selected polyhydroxyacids: Polylactides (PLA), poly(3-hydroxybutyrate) (PHB), and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB/VA). J Biomed Mater Res. 1993;27:1135
  11. Schmidmaier G, Baehr K, Mohr S, et al. Biodegradable polylactide membranes for bone defect coverage: Biocompatibility testing, radiological and histological evaluation in a sheep model. Clin Oral Implants Res. 2006;17:439
  12. Pineda LM, Busing M, Meinig RP, et al. Bone regeneration with resorbable polymeric membranes (III. Effect of poly(L-lactide) membrane pore size on the bone healing process in large defects). J Biomed Mater Res. 1996;31:385
  13. Gugala Z, Gogolewski S. Regeneration of segmental diaphyseal defects in sheep tibiae using resorbable polymeric membranes: A preliminary study. J Orthop Trauma. 1999;13:187
  14. Gugala Z, Gogolewski S. Healing of critical-size segmental bone defects in the sheep tibiae using bioresorbable polylactide membranes. Injury. 2002;33(Suppl 2):B71
  15. Scantlebury TV. 1982–1992: A decade of technology development for guided tissue regeneration. J Periodontol. 1993;64(11 Suppl):1129
  16. Schenk RK, Buser D, Hardwick WR, et al. Healing pattern of bone regeneration in membrane-protected defects: A histologic study in the canine mandible. Int J Oral Maxillofac Implants. 1994;9:13
  17. Buser D, Dula K, Belser UC, et al. Localized ridge augmentation using guided bone regeneration (II. Surgical procedure in the mandible). Int J Periodtol Restor Dent. 1995;15:10
  18. Hardwick R, Hayes BK, Flynn C. Devices for dentoalveolar regeneration: An up-to-date literature review. J Periodontol. 1995;66:495
  19. Dahlin C, Simion M, Nanmark U, et al. Histological morphology of the e-PTFE/tissue interface in humans subjected to guided bone regeneration in conjunction with oral implant treatment. Clin Oral Implants Res. 1998;9:100
  20. Huh JY, Choi BH, Kim BY, et al. Critical size defect in the canine mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:296
  21. De Marco AC, Jardini MA, Lima LP. Revascularization of autogenous block grafts with or without an e-PTFE membrane. Int J Oral Maxillofac Implants. 2005;20:867
  22. Salata LA, Rasmusson L, Kahnberg KE. Effects of a mechanical barrier on the integration of cortical onlay bone grafts placed simultaneously with endosseous implant. Clin Implant Dent Relat Res. 2002;4:60
  23. Schmid J, Hammerle CHF, Olah AJ, et al. Membrane permeability is unnecessary for guided generation of new bone: An experimental study in the rabbit. Clin Oral Implants Res. 1994;5:125
  24. Donos N, Kostopoulos L, Karring T. Augmentation of the mandible with GTR and onlay cortical bone grafting: An experimental study in the rat. Clin Oral Implants Res. 2002;13:175
  25. Donos N, Kostopoulos L, Karring T. Alveolar ridge augmentation by combining autogenous mandibular bone grafts and non-resorbable membranes. Clin Oral Implants Res. 2002;13:185
  26. Donos N, Kostopoulos L, Karring T. Alveolar ridge augmentation using a resorbable copolymer membrane and autogenous bone grafts: An experimental study in the rat. Clin Oral Implants Res. 2002;13:203
  27. Kleinbeinz J, Stratmann U, Joos U, et al. VEGF-activated angiogenesis during bone regeneration. J Oral Maxillofac Surg. 2005;63:1310
  28. Mardas N, Kostopoulos L, Stavropoulos A, et al. Evaluation of a cell-permeable barrier for guided tissue regeneration combined with desmineralized bone matrix. Clin Oral Implants Res. 2003;14:812
  29. Gerber A, Gogolewski S. Reconstruction of large segmental defects in the sheep tibia using polylactide membranes: A clinical and radiographic report. Injury. 2002;33(Suppl 2):B43

 Supported by the AO Foundation, Dübendorf, Switzerland, and the São Paulo Research Foundation (FAPESP), Brazil

PII: S0278-2391(07)01511-X

doi: 10.1016/j.joms.2007.06.664

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 4 , Pages 647-656 , April 2008

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