Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 11 , Pages 2356-2363 , November 2008

Uncovering the Cause of “Phossy Jaw” Circa 1858 to 1906: Oral and Maxillofacial Surgery Closed Case Files—Case Closed

  • Robert E. Marx, DDS

      Affiliations

    • Professor of Surgery and Chief, Division of Oral and Maxillofacial Surgery, University of Miami Miller School of Medicine, Miami, FL
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Marx: Division of Oral and Maxillofacial Surgery, Miller School of Medicine, University of Miami, 9380 SW 150th St, Suite 190, Miami, FL 33157

References 

  1. Marx RE. Pamidronate (Aredia)- and zoledronate (Zometa)-induced avascular necrosis of the jaws: A growing epidemic [letter]. J Oral Maxillofac Surg. 2003;61:1115
  2. Hellenstein SW, Marek OL. Bisphosphonate chemonecrosis (bis-phossy jaw): Is this phossy jaw of the 21st century?. J Oral Maxillofac Surg. 2005;63:682
  3. Miglioratic CA, Schbert MM, Petersen DE, et al. Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone: An emerging oral complication of supportive cancer therapy. Cancer. 2005;104:83
  4. Ruggerio SL, Mekrotin B, Rosenberg TJ, et al. Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases. J Oral Maxillofac Surg. 2004;62:527
  5. Dearden WF. Fragilitas adduim amongst workers in Lucifer match factories. BMJ. 1899;2:270
  6. Smith J. Case report. St Bart Hosp Rep. 1865;1:101
  7. Marx RE, Sawatari Y, Fortin M, et al. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: Risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005;63:1567
  8. Chevalier MA, Pirier A. J Chim Med. 1858;4:139
  9. Simon J. Fifo Report of the Medical Officer of the Privy Council. HMSU London. 1863;
  10. Thorpe TE, Oliver T, Cunningham G. Report on the use of phosphorus in manufacture of lucifer matches. HMSO London. 1899;
  11. Miles AEW. Phosphorus necrosis of the jaws: “Phossy jaw.”. Br Dent J. 1972;133:203
  12. Fleming RBL, Miller JW, Swayne VR. Phosphorous necrosis. J Indust Hyg. 1942;154
  13. Ward EF. Phosphorus necrosis in the manufacture of fireworks. J Indust Hyg. 1928;10:319
  14. Wakefield BG. Phosphorus necrosis of the jaws. J Oral Surg. 1948;6:203
  15. Kennon R, Hallam JW. Modern phosphorus caries and necrosis. Br Dent J76. 1944;321
  16. Goldblatt NV, Oakerhott SH. Inactivation of phosphorus on the skin. Brit Med J. 1943;3:128
  17. Rogers MJ, Gordon S, Benford HL, et al. Cellular and molecular mechanisms of actions of bisphosphonates. Cancer. 2000;88(Suppl):2967
  18. Lasseter KC, Porras AG, Denker A, et al. Pharmacokinetic considerations in determining the terminal elimination half-lives of bisphosphonates. Clin Drug Invest. 2005;25:107
  19. Marx RE. Oral and Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws: History, Etiology, Prevention, and Treatment. Hanover Park, IL: Quintessence; 2006;
  20. Dixon RB, Trickler ND, Garetto LP. Bone turnover in elderly canine mandible and tibia. J Dent Res. 1997;76:2579
  21. Vignery A, Baron R. Dynamic histomorphometry of alveolar bone remodeling in the adult rat. Anta Res. 1980;196:191
  22. Garrett RG, Grisham CM. Coenzymes and vitamins. In:  Garrett RG,  Grisham CM editor. Biochemistry. Orlando, FL: Harcourt Brace; 1995;p. 498–501
  23. Machlin LJ. Handbook of Vitamins. New York: Marcel Dekker; 1984;

PII: S0278-2391(07)02033-2

doi: 10.1016/j.joms.2007.11.006

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 11 , Pages 2356-2363 , November 2008