Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 5 , Pages 905-910 , May 2008

Histomorphometric Evaluation of the Effects of Zoledronic Acid on Mandibular Distraction Osteogenesis in Rabbits

  • A. Alper Pampu, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Oral and Maxillofacial Surgery, Karadeniz Technical University, Faculty of Dentistry, Trabzon, Turkey.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Pampu: Selcuk University Faculty of Dentistry, Oral and Maxillofacial Surgery, Selcuk Universitesi Dis Hekimligi, Agiz Dis Cene Hastaliklari ve Cer, 42079 Konya, Turkey
    • ,
  • Doğan Dolanmaz, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Selcuk University Faculty of Dentistry, Konya, Turkey.
    • ,
  • Hakan H. Tüz, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Kırıkkale University, Faculty of Dentistry, Kırıkkale, Turkey.
    • ,
  • M. Cihat Avunduk, MD

      Affiliations

    • Professor, Department of Pathology, Meram Medical Faculty, Selcuk University, Konya, Turkey.
    • ,
  • Reha Ş. Kisşnisşci, DDS, PhD

      Affiliations

    • Professor, Department of Oral and Maxillofacial Surgery, Ankara University Faculty of Dentistry, Ankara, Turkey.

References 

  1. Terheyden H, Wang H, Warnke PH, et al. Acceleration of callus maturation using rhOP-1 in mandibular distraction osteogenesis in a rat model. Int J Oral Maxillofac Surg. 2003;32:528
  2. Little DG, Cornell MS, Hile MS, et al. Effect of pamidronate on distraction osteogenesis and fixator-related osteoporosis. Injury. 2001;32:14
  3. Paley D. Problems, obstacles, and complications of limb lengthening by the Ilizarov technique. Clin Orthop Relat Res. 1990;250:81
  4. Tsubota S, Tsuchiya H, Shinokawa Y, et al. Transplantation of osteoblast-like cells to the distracted callus in rabbits. J Bone Joint Surg Br. 1999;81:125
  5. Okazaki H, Kurokawa T, Nakamura K, et al. Stimulation of bone formation by recombinant fibroblast growth factor-2 in callotasis bone lengthening of rabbits. Calcif Tissue Int. 1999;64:542
  6. Bail HJ, Raschke MJ, Kolbeck S, et al. Recombinant species-specific growth hormone increases hard callus formation in distraction osteogenesis. Bone. 2002;30:117
  7. El-Mowafi H, Mohsen M. The effect of low-intensity pulsed ultrasound on callus maturation in tibial distraction osteogenesis. Int Orthop. 2005;29:121
  8. Little DG, Cornell MS, Briody J, et al. Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis (A study in immature rabbits). J Bone Joint Surg Br. 2001;83:1069
  9. Little DG, Smith NC, Williams PR, et al. Zoledronic acid prevents osteopenia and increases bone strength in a rabbit model of distraction osteogenesis. J Bone Miner Res. 2003;18:1300
  10. Smith SW, Sachdeva RC, Cope JB. Evaluation of the consolidation period during osteodistraction using computed tomography. Am J Orthod Dentofacial Orthop. 1999;116:254
  11. Fleisch H. Bisphosphonates in Bone Disease: From the Laboratory to the Patients. ed 4. San Diego: Academic Press; 2000;
  12. Sato M, Grasser W, Endo N, et al. Bisphosphonate action (Alendronate localization in rat bone and effects on osteoclast ultrastructure). J Clin Invest. 1991;88:2095
  13. Sietsema WK, Ebetino FH, Salvagno AM, et al. Antiresorptive dose-response relationships across three generations of bisphosphonates. Drugs Exp Clin Res. 1989;15:389
  14. Rogers MJ, Watts DJ, Russell RG. Overview of bisphosphonates. Cancer. 1997;80(suppl 8):1652
  15. Plotkin LI, Weinstein RS, Parfitt AM, et al. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest. 1999;104:1363
  16. Coxon FP, Helfrich MH, Van't Hof R, et al. Protein geranylgeranylation is required for osteoclast formation, function, and survival: Inhibition by bisphosphonates and GGTI-298. J Bone Miner Res. 2000;15:1467
  17. Nielson OS, Munro AJ, Tannock IF. Bone metastasis: Pathophysiology and management policy. J Clin Oncol. 1991;9:509
  18. Benford HL, McGowan NW, Helfrich MH, et al. Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro. Bone. 2001;28:465
  19. Dunford JE, Thompson K, Coxon FP, et al. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001;296:235
  20. Green JR. Chemical and biological prerequisites for novel bisphosphonate molecules: Results of comparative preclinical studies. Semin Oncol. 2001;28(suppl 6):4
  21. Boissier S, Ferreras M, Peyruchaud O, et al. Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases. Cancer Res. 2000;60:2949
  22. Danziger MB, Kumar A, DeWeese J. Fractures after femoral lengthening using the Ilizarov method. J Pediatr Orthop. 1995;15:220
  23. Simpson AH, Kenwright J. Fracture after distraction osteogenesis. J Bone Joint Surg Br. 2000;82:659
  24. Bilston LE, Little DG, Smith NC, et al. Zoledronic acid improves the mechanical properties of normal and healing bone. Clin Biomech. 2002;17:716
  25. Williams PR, Smith NC, Cooke-Yarborough C, et al. Bisphosphonates and nephrocalcinosis in a rabbit leg lengthening model: A histological and therapeutic comparison. Pharmacol Toxicol. 2001;89:149
  26. Pampu AA, Dolanmaz D, Tuz HH, et al. Experimental evaluation of the effects of zoledronic acid on regenerate bone formation and osteoporosis in mandibular distraction osteogenesis. J Oral Maxillofac Surg. 2006;64:1232
  27. Smith EJ, McEvoy A, Little DG, et al. Transient retention of endochondral cartilaginous matrix with bisphosphonate treatment in a long-term rabbit model of distraction osteogenesis. J Bone Miner Res. 2004;19:1698
  28. Qiu S, Rao DS, Palnitkar S, et al. Relationships between osteocyte density and bone formation rate in human cancellous bone. Bone. 2002;31:709
  29. Ninomiya T, Hosoya A, Nakamura H, et al. Increase of bone volume by a nanosecond pulsed laser irradiation is caused by a decreased osteoclast number and an activated osteoblasts. Bone. 2007;40:140
  30. Assael LA. New foundations in understanding osteonecrosis of the jaws. (editorial) J Oral Maxillofac Surg. 2004;62:125
  31. Marx RE, Sawatari Y, Fortin M, et al. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: Risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005;63:1567
  32. Badros A, Weikel D, Salama A, et al. Osteonecrosis of the jaw in multiple myeloma patients: Clinical features and risk factors. J Clin Oncol. 2006;24:945
  33. Shankland WE. Medullary and odontogenic disease in the painful jaw: Clinicopathologic review of 500 consecutive lesions. Cranio. 2002;20:295
  34. Pozzı S, Marcheselli R, Sacchi S, et al. Bisphosphonate-associated osteonecrosis of the jaw: A review of 35 cases and an evaluation of its frequency in multiple myeloma patients. Leuk Lymphoma. 2007;48:56

 This study was supported by Scientific Research Project, Selçuk University, Konya, Turkey.

PII: S0278-2391(07)02110-6

doi: 10.1016/j.joms.2007.12.004

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 5 , Pages 905-910 , May 2008

Article Tools

* Image Usage & Resolution