Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 4 , Pages 616-624 , April 2008

Reconstruction of Mandibular Continuity Defects With Bone Morphogenetic Protein-2 (rhBMP-2)

  • Alan S. Herford, DDS, MD

      Affiliations

    • Chairman, Department of Oral and Maxillofacial Surgery, Loma Linda University Medical Center, Loma Linda, CA.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Herford: Loma Linda University, Department of Oral and Maxillofacial Surgery, 11092 Anderson Street, Loma Linda, CA 92350
    • ,
  • Philip J. Boyne, DMD, MS, DSc

      Affiliations

    • Professor Emeritus, Department of Oral and Maxillofacial Surgery, Loma Linda University Medical Center, Loma Linda, CA.

References 

  1. Boyne PJ. A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects (Discussion). J Oral Maxillofac Surg. 1997;55:1206
  2. Urist MR. Bone formation by autoinduction. Science. 1965;150:893–899
  3. Urist MR, Mikulski A, Lutz A. Solubilized and insolubilized bone morphogenetic protein. Proc Natl Acad Sci USA. 1979;76:1828
  4. Wozney J. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev. 1992;32:160
  5. Boyne PJ. Application of bone morphogenetic proteins in the treatment of clinical oral and maxillofacial osseous defects. J Bone Joint Surg. 2001;83A:146
  6. Boyne PJ, Salina S, Nakamura A, et al. Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates. Cell Tissue Bank. 2006;7:1
  7. Boyne PJ. An evaluation of bone induction delivery materials in conjunction with root-form implant placement. Oral Maxillofac Surg Clin North Am. 2001;13:521
  8. Toriumi DM, Kotler HS, Luxenberg DP, et al. Mandibular reconstruction with a recombinant bone-inducing factor (Functional, histologic, and biomechanical evaluation). Arch Otolaryngol Head Neck Surg. 1991;117:1101
  9. Boyne PJ, Lilly LC, Marx RE, et al. De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. J Oral Maxillofac Surg. 2005;63:1693
  10. Katagiri K, Yamaguchi A, Komaki M, et al. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol. 1994;127:1755
  11. Boyne PJ. The restoration of resected mandibles in children without the use of bone grafts. J Head and Neck Surg. 1983;6:626
  12. Johnson EE, Urist MR, Finerman GA. Resistant nonunions and partial or complete segmental defects of long bones (Treatment with implants of a composite of human bone morphogenetic protein (BMP) and autolyzed, antigen-extracted, allogeneic (AAA) bone). Clin Orthop Relat Res. 1992;227:229
  13. Zellin G, Linde A. Importance of delivery systems for growth-stimulatory factors in combination with osteopromotive membranes (An experimental study using rhBMP-2 in rat mandibular defects). J Biomed Mater Res. 1997;35:181
  14. Boyne PJ, Marx RE, Nevins M, et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodont Rest Dent. 1997;17:11
  15. Nevins M, Kirker-head C, Nevins M, et al. Bone formation in the goat maxillary sinus induced by absorbable collagen sponge implants impregnated with recombinant human bone morphogenetic protein-2. Int J Periodont Rest Dent. 1996;16:9

PII: S0278-2391(07)02116-7

doi: 10.1016/j.joms.2007.11.021

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 4 , Pages 616-624 , April 2008

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