Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 4 , Pages 767-775 , April 2008

Identification of Microbial Biofilms in Osteonecrosis of the Jaws Secondary to Bisphosphonate Therapy

  • Parish P. Sedghizadeh, DDS, MS

      Affiliations

    • Assistant Clinical Professor, Division of Diagnostic Sciences, and Center for Craniofacial Molecular Biology, University of Southern California, School of Dentistry, Los Angeles, CA.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Sedghizadeh: 925 West 34th Street, Rm 4276, University of Southern California, School of Dentistry, Center for Craniofacial Molecular Biology, Los Angeles, CA 90089-0641
    • ,
  • Satish K.S. Kumar, BDS, MDSc

      Affiliations

    • Senior Resident, Orofacial Pain and Oral Medicine Center, Division of Diagnostic Sciences, University of Southern California, School of Dentistry, Los Angeles, CA.
    • ,
  • Amita Gorur, MS

      Affiliations

    • Research Associate, Center for Biofilms, University of Southern California, School of Dentistry, Los Angeles, CA.
    • ,
  • Christoph Schaudinn, PhD

      Affiliations

    • Postdoctoral Research Associate, Center for Biofilms, University of Southern California, School of Dentistry, Los Angeles, CA.
    • ,
  • Charles F. Shuler, DMD, PhD

      Affiliations

    • Director, Center for Craniofacial Molecular Biology, George and Mary Lou Boone Chair of Craniofacial Molecular Biology, University of Southern California, School of Dentistry, Los Angeles, CA.
    • ,
  • J. William Costerton, PhD

      Affiliations

    • Director, Center for Biofilms, University of Southern California, School of Dentistry, Los Angeles, CA.

References 

  1. Costerton JW. Biofilm theory can guide the treatment of device-related orthopedic infections. Clin Orthop Rel Res. 2005;437:7
  2. Ehrlich GD, Stoodley P, Kathju S, et al. Engineering approaches for the detection and control of orthopaedic biofilm infections. Clin Ortho Rel Res. 2005;437:59
  3. Patel R. Biofilms and antimicrobial resistance. Clin Ortho Rel Res. 2005;437:41
  4. Donlan RM, Costerton JW. Biofilms: Survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev. 2002;15:167
  5. Stewart PS, Costerton JW. Antibiotic resistance of bacteria in biofilms. Lancet. 2001;358:135
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  9. Ruggiero SL, Fantasia J, Carlson E. Bisphosphonate-related osteonecrosis of the jaw: Background and guidelines for diagnosis, staging and management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:433
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  11. Migliorati CA, Siegel MA, Elting LS. Bisphosphonate-associated osteonecrosis: A long-term complication of bisphosphonate treatment. Lancet Oncol. 2006;7:508
  12. Woo SB, Hellstein JW, Kalmar JR. Narrative [corrected] review: Bisphosphonates and osteonecrosis of the jaws. Ann Intern Med. 2006;144:753
  13. Jenkinson HF, Lala CH, Shepherd GM. Coaggregation of Streptococcus Sanguis and other Streptococci with Candida albicans. Infect Immun. 1990;58:1429
  14. Nair SP, Meghji S, Wilson M, et al. Bacterially induced bone destruction: Mechanisms and misconceptions. Infect Immun. 1996;64:2371
  15. Meghji S, Henderson B, Nair SP, et al. Bacterial porins stimulate bone resorption. Infect Immun. 1997;65:1313
  16. Harrington DJ. Bacterial collagenases and collagen-degrading enzymes and their potential role in human disease. Infect Immun. 1996;64:1885
  17. Merigo E, Manfredi M, Meleti M, et al. Jaw bone necrosis without previous dental extractions associated with the use of bisphosphonates (pamidronate and zoledronate): A four-case report. J Oral Pathol Med. 2005;34:613
  18. Badros A, Weikel D, Salama A, et al. Osteonecrosis of the jaw in multiple myeloma patients: Clinical features and risk factors. J Clin Oncol. 2006;24:945
  19. Veeh RH, ME Shirtliff Jr, Petik JA, et al: Detection of Staphylococcus aureus biofilm on tampons and menses components. J Infect Dis 188:519, 2003
  20. Wade W. Unculturable bacteria—The uncharacterized organisms that cause oral infections. J R Soc Med. 2002;95:81
  21. DuGuid IG, Evans E, Brown MRW, et al. Effect of biofilm culture on the susceptibility of Staphylococcus epidermidis to tobramycin. J Antimicrob Chemother. 1992;30:803
  22. Nelson CL, McLaren AC, McLaren SG, et al. Is aseptic loosening truly aseptic?. Clin Orthop Rel Res. 2005;437:25
  23. Gristina AG, Oga M, Webb LX, et al. Adherent bacterial colonization in the pathogenesis of osteomyelitis. Science. 1985;228:900

PII: S0278-2391(07)02133-7

doi: 10.1016/j.joms.2007.11.035

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 4 , Pages 767-775 , April 2008

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