Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 5 , Pages 918-927 , May 2008

Characterization of Gene Expression Profiles of 3 Different Human Oral Squamous Cell Carcinoma Cell Lines With Different Invasion and Metastatic Capacities

  • N. Fazil Erdem, DDS, PhD

      Affiliations

    • Intern, Department of Oral and Maxillofacial Surgery, University of Tennessee Graduate School of Medicine, and the University of Tennessee Cancer Institute, Knoxville, TN.
    • ,
  • Eric R. Carlson, DMD, MD

      Affiliations

    • Professor and Chairman, Department of Oral and Maxillofacial Surgery, University of Tennessee Graduate School of Medicine, and the University of Tennessee Cancer Institute, Knoxville, TN.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Carlson: 1930 Alcoa Highway, Suite 335, Knoxville, TN 37920
    • ,
  • David A. Gerard, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, University of Tennessee Graduate School of Medicine, and the University of Tennessee Cancer Institute, Knoxville, TN.

References 

  1. Yamamoto K, Konishi N, Inui T, et al. Genomic alterations in oral squamous cell carcinoma cell lines detected by two-dimensional gel analysis. Oral Oncol. 1998;34:508
  2. Scully C, Field JK, Tanzawa H. Genetic aberration in oral or head and neck squamous cell carcinoma (SCCHN), 1: Carcinogen metabolism, DNA repair and cell cycle control. Oral Oncol. 2000;36:256
  3. Scully C, Field JK, Tanzawa H. Genetic aberration in oral or head and neck squamous cell carcinoma, 2: Chromosomal aberrations. Oral Oncol. 2000;36:311
  4. Ginos MA, Page GP, Michalowicz BS, et al. Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res. 2004;64:55
  5. Choi P, Chen C. Genetic expression profiles and biologic pathway alterations in head and neck squamous cell carcinoma. Cancer. 2005;104:1113
  6. Li Y, Tondravi M, Liu J, et al. Cortactin potentiates bone metastasis of breast cancer cells. Cancer Res. 2001;61:6906
  7. Akhurst RJ, Derynck R. TGF-β signaling in cancer: A double-edged sword. Trends Cell Bio. 2001;11:44
  8. St Jacques B, Hammerschmidt M, McMahon AP. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 1999;13:2072
  9. Kubo M, Nakamura M, Tasaki A, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res. 2004;64:6071
  10. Snijders AM, Schmidt BL, Fridlyan J, et al. Rare amplicons implicate frequent deregulation of cell fate specification pathway in oral squamous cell carcinoma. Oncogene. 2005;24:4232
  11. Zheng D, Woodard AS, Fornaro M, et al. Prostatic carcinoma cell migration via αvβ3 integrin is modulated by a focal adhesion kinase pathway. Cancer Res. 1999;59:1655
  12. Ossowski L, Aguirre-Ghiso JA. Urokinase receptor and integrin partnership: Coordination of signaling for cell adhesion, migration and growth. Curr Opin Cell Biol. 2000;12:613
  13. Chott A, Sun Z, Morganstern D, et al. Tyrosine kinases expressed in vivo by human prostate cancer bone marrow metastases and loss of the type 1 insulin-like growth factor receptor. Am J Pathol. 1999;155:1271
  14. Westermarck A, Kahari V. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 1999;13:781
  15. Liao J, Schneider A, Datta NS, et al. Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis. Cancer Res. 2006;66:9065
  16. Amuthan G, Biswas G, Ananadatheerthavarada HK, et al. Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells. Oncogene. 2002;21:7839
  17. Basile JR, Castilho RM, Williams VP, et al. Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. Proc Natl Acad Sci. 2006;103:9017
  18. Christensen C, Ambartsumian N, Gilestro G, et al. Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis. Cancer Res. 2005;65:6167
  19. Aliprantis AO, Yang R, Weiss DS, et al. The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J. 2000;19:3325
  20. Ertel A, Verghese A, Byers SW, et al. Pathway-specific differences between tumor cell lines and normal and tumor tissue cells. Mol Cancer. 2006;5:1
  21. Dysvik B, Vasstrand EN, Lovlie R, et al. Gene expression profiles of head and neck carcinomas from Sudanese and Norwegian patients reveal common biological pathways regardless of race and lifestyle. Clin Cancer Res. 2006;12:1109
  22. Bjarnason GA, Jordan CK, Sothern RB. Circadian variation in the expression of cell-cycle proteins in human oral epithelium. Am J Pathol. 1999;153:613
  23. Leethanakul C, Patel V, Gillespie J, et al. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene. 2000;19(28):3220
  24. Yeh KT, Chang JD, Lin TH, et al. Correlation between protein expression and epigenetic and mutation changes of Wnt pathway-related genes in oral cancer. Int J Oncol. 2003;23:1001
  25. Kudo Y, Kitajima S, Ogawa I, et al. Invasion and metastasis of oral cancer cells require methylation of E-cadherin and/or degradation of membranous β-catenin. Clin Cancer Res. 2004;10:5455
  26. Santagata S, Demichelis F, Riva A, et al. JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res. 2004;64:6854
  27. Thomas GJ, Speight PM. Cell adhesion molecules and oral cancer. Crit Rev Oral Biol Med. 2001;12:479
  28. Livny O, Kaplan I, Reifen R, et al. Lycopene inhibits proliferation and enhances gap-junction communication of KB-1 human oral tumor cells. J Nutr. 2002;132:3754

 This research was supported by the Physician's Medical Education and Research Foundation (PMERF), University of Tennessee Medical Center, Knoxville.

PII: S0278-2391(08)00012-8

doi: 10.1016/j.joms.2007.12.036

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 5 , Pages 918-927 , May 2008

Article Tools

* Image Usage & Resolution