Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 2 , Pages 280-285 , February 2009

Granulomatous Foreign-Body Reaction Involving Oral and Perioral Tissues After Injection of Biomaterials: A Series of 7 Cases and Review of the Literature

  • Bruno C. Jham, DDS, MS

      Affiliations

    • Resident and Doctoral Student in Oral and Maxillofacial Pathology, Department of Diagnostic Sciences and Pathology, University of Maryland Dental School, Baltimore, MD
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Jham: Department of Diagnostic Sciences and Pathology, University of Maryland Dental School, 650 West Baltimore St, Floor 7 North, Baltimore MD, 21201
    • ,
  • Nikolaos G. Nikitakis, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Oral Pathology and Medicine, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece
    • ,
  • Mark A. Scheper, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Diagnostic Sciences and Pathology, University of Maryland Dental School, Baltimore, MD
    • ,
  • John C. Papadimitriou, MD, PhD

      Affiliations

    • Professor, Department of Pathology, University of Maryland School of Medicine, Baltimore, MD
    • ,
  • Bernard A. Levy, DDS, MSD

      Affiliations

    • Professor and Program Director, Department of Diagnostic Sciences and Pathology, University of Maryland Dental School, Baltimore, MD
    • ,
  • Helen Rivera, DDS, MS

      Affiliations

    • Professor, Institute of Dental Research, Oral Pathology Laboratory, Faculty of Dentistry, Central University of Venezuela, Ciudad Universitaria, Caracas, Venezuela

References 

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  2. Waris E, Pakkanen M, Lassila K, et al. Alloplastic injectable biomaterials for soft tissue augmentation: A report on two cases with complications associated with a new material (DermaLive) and a review of the literature. Eur J Plast Surg. 2003;26:350
  3. Mastruserio DN, Pesqueira MJ, Cobb MW. Severe granulomatous reaction and facial ulceration occurring after subcutaneous silicone injection. J Am Acad Dermatol. 1996;34:849
  4. Hubmer MG, Hoffmann C, Popper H, et al. Expanded polytetrafluoroethylene threads for lip augmentation induce foreign body granulomatous reaction. Plast Reconstr Surg. 1999;103:1277
  5. Rudolph CM, Soyer HP, Schuller-Petrovic S, et al. Foreign body granulomas due to injectable aesthetic microimplants. Am J Surg Pathol. 1999;23:113
  6. Bigata X, Ribera M, Bielsa I, et al. Adverse granulomatous reaction after cosmetic dermal silicone injection. Dermatol Surg. 2001;27:198
  7. Ficarra G, Mosqueda-Taylor A, Carlos R. Silicone granuloma of the facial tissues: A report of seven cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:65
  8. Lombardi T, Samson J, Plantier F, et al. Orofacial granulomas after injection of cosmetic fillers (Histopathologic and clinical study of 11 cases). J Oral Pathol Med. 2004;33:115
  9. Requena C, Izquierdo MJ, Navarro M, et al. Adverse reactions to injectable aesthetic microimplants. Am J Dermatopathol. 2001;23:197
  10. Baumann LS, Halem ML. Lip silicone granulomatous foreign body reaction treated with Aldara (imiquimod 5%). Dermatol Surg. 2003;29:429
  11. Fernandez-Acenero MJ, Zamora E, Borbujo J. Granulomatous foreign body reaction against hyaluronic acid: Report of a case after lip augmentation. Dermatol Surg. 2003;29:1225
  12. Maly A, Regev E, Meir K, et al. Tissue reaction to liquid silicone simulating low-grade liposarcoma following lip augmentation. J Oral Pathol Med. 2004;33:314
  13. Schmidt-Westhausen AM, Frege J, Reichart PA. Abscess formation after lip augmentation with silicone: Case report. Int J Oral Maxillofac Surg. 2004;33:198
  14. Dijkema SJ, van der Lei B, Kibbelaar RE. New-fill injections may induce late-onset foreign body granulomatous reaction. Plast Reconstr Surg. 2005;115:76e
  15. Edwards PC, Fantasia JE, Iovino R. Foreign body reaction to hyaluronic acid (Restylane): An adverse outcome of lip augmentation. J Oral Maxillofac Surg. 2006;64:1296
  16. Poveda R, Bagan JV, Murillo J, et al. Granulomatous facial reaction to injected cosmetic fillers—A presentation of five cases. Med Oral Patol Oral Cir Bucal. 2006;11:E1
  17. Constantinides M, Zimbler MS, Jagirdar J. An unusual late reaction to facial injections. Otolaryngol Head Neck Surg. 1999;120:557
  18. Hoffmann C, Schuller-Petrovic S, Soyer HP, et al. Adverse reactions after cosmetic lip augmentation with permanent biologically inert implant materials. J Am Acad Dermatol. 1999;40:100
  19. Heise H, Zimmermann R, Heise P. Temporary granulomatous inflammation following collagen implantation. J Craniomaxillofac Surg. 2001;29:238
  20. Honig JF, Brink U, Korabiowska M. Severe granulomatous allergic tissue reaction after hyaluronic acid injection in the treatment of facial lines and its surgical correction. J Craniofac Surg. 2003;14:197
  21. Sidwell RU, Dhillon AP, Butler PE, et al. Localized granulomatous reaction to a semi-permanent hyaluronic acid and acrylic hydrogel cosmetic filler. Clin Exp Dermatol. 2004;29:630
  22. Vargas-Machuca I, Gonzalez-Guerra E, Angulo J, et al. Facial granulomas secondary to Dermalive microimplants: Report of a case with histopathologic differential diagnosis among the granulomas secondary to different injectable permanent filler materials. Am J Dermatopathol. 2006;28:173
  23. Redondo P, Del Olmo J, Alberola I. In situ and distant foreign body granulomas caused by silicone (Treatment with allopurinol). Br J Dermatol. 2005;152:1064
  24. Wolfram D, Tzankov A, Piza-Katzer H. Surgery for foreign body reactions due to injectable fillers. Dermatology. 2006;213:300
  25. Mustacchio V, Cabibi D, Minervini MI, et al. A diagnostic trap for the dermatopathologist: Granulomatous reactions from cutaneous microimplants for cosmetic purposes. J Cutan Pathol. 2007;34:281
  26. Perenack J. Treatment options to optimize display of anterior dental esthetics in the patient with the aged lip. J Oral Maxillofac Surg. 2005;63:1634
  27. Fulton JE, Porumb S, Caruso JC, et al. Lip augmentation with liquid silicone. Dermatol Surg. 2005;31:1577
  28. Evans HL. Atypical lipomatous tumor, its variants, and its combined forms: A study of 61 cases, with a minimum follow-up of 10 years. Am J Surg Pathol. 2007;31:1

 B.C.J. gratefully acknowledges National Counsel of Technological and Scientific Development-Brazil doctorate scholarship 201590/2006-9.

PII: S0278-2391(08)00108-0

doi: 10.1016/j.joms.2008.01.052

Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 2 , Pages 280-285 , February 2009

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