Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 7 , Pages 1417-1425 , July 2008

Off-Label Use of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) for Reconstruction of Mandibular Bone Defects in Humans

  • Todd G. Carter, DMD

      Affiliations

    • Private Practice, Wailuku, HI; and Formerly, Chief Resident, University of Washington, Department of Oral and Maxillofacial Surgery, Seattle, WA.
    • ,
  • Pardeep S. Brar, DMD

      Affiliations

    • Chief Resident, University of Washington, Department of Oral and Maxillofacial Surgery, Seattle, WA.
    • ,
  • Andrew Tolas, DDS

      Affiliations

    • Private Practice, Kent, WA; and Clinical Associate Professor, University of Washington, Department of Oral and Maxillofacial Surgery, Seattle, WA.
    • ,
  • O. Ross Beirne, DMD, PhD

      Affiliations

    • Professor and Chair, University of Washington, Department of Oral and Maxillofacial Surgery, Seattle, WA.
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Beirne: University of Washington, Department of Oral and Maxillofacial Surgery, Box 357134, Seattle, WA 98195-7134

References 

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  3. Kalk WWI, Raghoebar GM, Jansma J, et al. Morbidity from iliac crest bone harvesting. J Oral Maxillofac Surg. 1996;54:1424
  4. Beirne OR. Comparison of complications after bone removal from lateral and medial plates of the anterior ilium for mandibular augmentation. Int J Oral Maxillofac Surg. 1986;15:269
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  7. Toriumi DM, Kotler HS, Luxenberg DP, et al. Mandibular reconstruction with a recombinant bone inducing factor. Arch Otolaryngol Head Neck Surg. 1991;117:1101
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  10. Moghadam HG, Urist T, Sandor GK, et al. Successful mandibular reconstruction using a BMP bio-implant. J Craniofac Surg. 2001;12:119
  11. Terheyden H, Knak C, Jepsen S, et al. Mandibular reconstruction with a prefabricated vascularized bone graft using recombinant human osteogenic protein-1: An experimental study in miniature pigs (Part I: Prefabrication). Int J Oral Maxillofac Surg. 2001;30:373
  12. Terheyden H, Warnke P, Dunsche A, et al. Mandibular reconstruction with a prefabricated vascularized bone graft using recombinant human osteogenic protein-1: An experimental study in miniature pigs (Part II: Transplantation). Int J Oral Maxillofac Surg. 2001;30:469
  13. Warnke PH, Springer IN, Wiltfang J, et al. Growth and transplantation of a custom vascularized bone graft in a man. Lancet. 2004;364:766
  14. Urist MR, Granstein R, Nogami H, et al. Transmembrane bone morphogenesis across multiple walled diffusion chambers. Arch Surg. 1977;122:612
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  16. 2.1 Physician labeling (3/8/2007) Infuse bone graft for certain oral maxillofacial and dental regenerative uses (Important medical information, Rx only). http://www.fda.gov/cdrh/pdf5/p050053c.pdfAccessed December 18, 2007
  17. Chin M, Ng T, Tom W, et al. Repair of alveolar clefts with recombinant human bone morphogenetic protein (rhBMP-2) in patients with clefts. J Craniofac Surg. 2005;16:778
  18. Herford AS, Boyne PJ, Williams RP. Clinical applications of rhBMP-2 in maxillofacial surgery. J Calif Dent Assoc. 2007;35:335
  19. Smucker JD, Rhee JM, Singh K, et al. Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior spine. Spine. 2006;31:2813
  20. Nakahara H, Takaoka K, Koezuka M, et al. Periosteal bone formation elicited by partially purified bone morphogenetic protein. Clin Orthop. 1989;239:299
  21. King GN, Cochran DL. Factors that modulate the effects of bone morphogenetic protein-induced periodontal regeneration: A critical review. J Periodontol. 2002;73:925
  22. Pang EK, Im SU, Kim CS, et al. Effects of recombinant human bone morphogenetic protein-4 dose on bone formation in rat calvarial defects. J Periodontol. 2004;75:1364
  23. Kim CS, Kim JI, Kim J, et al. Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate carriers. Biomaterial. 2005;26:2501
  24. Boden SD. ABC's of BMPs. Orthop Nurs. 2005;24:49

PII: S0278-2391(08)00223-1

doi: 10.1016/j.joms.2008.01.058

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 7 , Pages 1417-1425 , July 2008

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