Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 9 , Pages 1875-1880 , September 2008

Prevalence and Significance of Human Papillomavirus in Oral Tongue Cancer: The Mayo Clinic Experience

  • Xin-Hua Liang, MD, PhD

      Affiliations

    • Research Fellow, Department of Oral and Maxillofacial Surgery, Mayo Clinic, Rochester, MN, and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China
  • ,
  • Jason Lewis, MD

      Affiliations

    • Assistant Professor, Department of Anatomic Pathology, Mayo Clinic, Rochester, MN
  • ,
  • Robert Foote, MD

      Affiliations

    • Professor of Oncology, Department of Radiation Oncology, Mayo Clinic, Rochester, MN
  • ,
  • David Smith, PhD

      Affiliations

    • Professor of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
  • ,
  • Deepak Kademani, DMD, MD

      Affiliations

    • Formerly, Assistant Professor, Department of Oral and Maxillofacial Surgery, Mayo Clinic, Rochester, MN; and Currently, Associate Professor, Department of Oral and Maxillofacial Surgery, University of Minnesota Medical Center, Minneapolis, MN
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Kademani: Oral and Maxillofacial Surgery, University of Minnesota Medical Center, Moos Tower 7-174G, 515 Delaware St, Minneapolis, MN 55455

References 

  1. Silverman S. Demographics and occurrence of oral and pharyngeal cancers (The outcomes, the trends, the challenge). J Am Dent Assoc. 2001;132(Suppl):7S
  2. Swango PA. Cancers of the oral cavity and pharynx in the United States: An epidemiologic overview. J Public Health Dent. 1996;56:309
  3. Kademani D. Oral cancer. Mayo Clin Proc. 2007;82:878
  4. Llewellyn CD, Johnson NW, Warnakulasuriya KA. Risk factors for squamous cell carcinoma of the oral cavity in young people—A comprehensive literature review. Oral Oncol. 2001;37:451
  5. Jemal A, Tiwari RC, Murray T, et al. Cancer statistics, 2004. CA. 2004;54:8
  6. In:  Ries LAG,  Harkins D,  Krapcho M, et al. editor. SEER Cancer Statistics Review, 1975-2003. Bethesda, MD: National Cancer Institute; 2006;http://seer.cancer.gov/csr/1975_2003/, based on November 2005 SEER data submission, posted to SEER website
  7. Rosenquist K. Risk factors in oral and oropharyngeal squamous cell carcinoma: A population-based case-control study in southern Sweden. Swed Dent J. 2005;179(Suppl):1
  8. Schantz SP, Yu GP. Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer. Arch Otolaryngol Head Neck Surg. 2002;128:268
  9. Llewellyn CD, Linklater K, Bell J, et al. : An analysis of risk factors for oral cancer in young people: A case-control study. Oral Oncol. 2004;45:304
  10. Annertz K, Anderson H, Biörklund A, et al. Incidence and survival of squamous cell carcinoma of the tongue in Scandinavia, with special reference to young adults. Int J Cancer. 2002;101:95
  11. Bosch FX, Manos MM, Muñoz N, et al. Prevalence of human papillomavirus in cervical cancer: A worldwide perspective (International Biological Study on Cervical Cancer (IBSCC) Study Group). JNCI. 1995;87:796
  12. Mork J, Lie AK, Glattre E, et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med. 2001;344:1125
  13. Gillison ML, Shah KV. Human papillomavirus-associated head and neck squamous cell carcinoma: Mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers. Curr Opin Oncol. 2001;13:183
  14. Sugerman PB, Shillitoe EJ. The high risk human papillomaviruses and oral cancer: Evidence for and against a causal relationship. Oral Dis. 1997;3:130
  15. Miller CS, White DK. Human papillomavirus expression in oral mucosa, premalignant conditions, and squamous cell carcinoma: A retrospective review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82:57
  16. Miloro M, Ghali GE, Larsen PE, et al. Peterson's Principles of Oral and Maxillofacial Surgery. In: (ed 2). Hamilton, Ontario, Canada: B.C. Decker, Inc; 2004;p. 617
  17. Davis S, Severson R. Increasing incidence of cancer of the tongue in the United States among young adults. Lancet. 1987;2:910
  18. Shiboski CH, Shiboski SC, Silverman S. Trends in oral cancer rates in the United States, 1973-1996. Community Dent Oral Epidemiol. 2000;28:249
  19. Myers JN, Elkins T, Roberts D, et al. Squamous cell carcinoma of the tongue in young adults: Increasing incidence and factors that predict treatment outcomes. Otolaryngol Head Neck Surg. 2000;122:44
  20. Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: Increasing trends in the U.S. population ages 20-44 years. Cancer. 2005;103:1843
  21. af Geijersstam V, Wang Z, Lewensohn-Fuchs I, et al. Trends in seroprevalence of human papillomavirus type 16 among pregnant women in Stockholm, Sweden, during 1969-1989. Int J Cancer. 1998;76:341
  22. Dillner J. Trends over time in the incidence of cervical neoplasia in comparison to trends over time in human papillomavirus infection. J Clin Virol. 2000;19:7
  23. Dahlgren L, Dahlstrand HM, Lindquist D, et al. Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favorable prognostic factor in base of tongue cancer patients. Int J Cancer. 2004;112:1015
  24. Koskinen WJ, Chen RW, Leivo I, et al. Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck. Int J Cancer. 2003;107:451
  25. Ringström E, Peters E, Hasegawa M, et al. Human papillomavirus type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res. 2002;8:3187
  26. Matzow T, Boysen M, Kalantari M, et al. Low detection rate of HPV in oral and laryngeal carcinomas. Acta Oncol. 1998;37:73
  27. Bouda M, Gorgoulis VG, Kastrinakis NG, et al. “High risk” HPV types are frequently detected in potentially malignant and malignant oral lesions, but not in normal oral mucosa. Mod Pathol. 2000;13:644
  28. Kozomara R, Jović N, Magić Z, et al. p53 mutations and human papillomavirus infection in oral squamous cell carcinomas: Correlation with overall survival. J Craniomaxillofac Surg. 2005;33:342
  29. Sotlar K, Diemer D, Dethleffs A, et al. Detection and typing of human papillomavirus by E6 nested multiplex PCR. J Clin Microbiol. 2004;42:3176
  30. Strome SE, Savva A, Brissett AE, et al. Squamous cell carcinoma of the tonsils: A molecular analysis of HPV associations. Clin Cancer Res. 2002;8:1093–1100
  31. Romanczuk H, Thierry F, Howley PM. Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters. J Virol. 1990;64:2849
  32. Wiest T, Schwarz E, Enders C, et al. Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene. 2002;21:1510
  33. Lechner MS, Mack DH, Finicle AB, et al. Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription. EMBO J. 1992;11:3045
  34. Scully C. Oral squamous cell carcinoma: From an hypothesis about a virus, to concern about possible sexual transmission. Oral Oncol. 2002;38:227
  35. Boy S, Van Rensburg EJ, Engelbrecht S, et al. HPV detection in primary intra-oral squamous cell carcinomas—Commensal, aetiological agent or contamination?. J Oral Pathol Med. 2006;35:86
  36. Syrjänen S. Human papillomavirus infections and oral tumors. Med Microbiol Immunol. 2003;192:123
  37. Miller CS, Johnstone BM. Human papillomavirus as a risk factor for oral squamous cell carcinoma: A meta-analysis, 1982-1997. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:622
  38. Van Rensburg EJ, Engelbrecht S, Van Heerden WF, et al. Human papillomavirus DNA in oral squamous cell carcinomas from an African population sample. Anticancer Res. 1996;16:969
  39. Kantola S, Parikka M, Jokinen K, et al. Prognostic factors in tongue cancer—Relative importance of demographic, clinical and histopathological factors. Br J Cancer. 2000;83:614
  40. Lacy PD, Piccirillo JF, Merritt MG, et al. Head and neck squamous cell carcinoma: Better to be young. Otolaryngol Head Neck Surg. 2000;122:253
  41. Klussmann JP, Weissenborn SJ, Wieland U, et al. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer. 2001;92:2875
  42. Begum S, Cao D, Gillison M, et al. Tissue distribution of human papillomavirus 16 DNA integration in patients with tonsillar carcinoma. Clin Cancer Res. 2005;11:5694
  43. Mellin H, Friesland S, Auer G, et al. Human papillomavirus and DNA ploidy in tonsillar cancer—Correlation to prognosis. Anticancer Res. 2003;23:2821
  44. Schwartz S, Yueh B, McDougall JK, et al. Human papillomavirus infection and survival in oral squamous cell cancer: A population-based study. Otolaryngol Head Neck Surg. 2001;125:1
  45. Ukpo OC. Human papillomavirus associated oropharyngeal squamous cell carcinoma: A distinct clinicopathological entity. In: Mayo Clinic College of Medicine Mayo Graduate School Master's Thesis; 2007;p. 32

PII: S0278-2391(08)00414-X

doi: 10.1016/j.joms.2008.04.009

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 9 , Pages 1875-1880 , September 2008