Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 11 , Pages 2233-2238 , November 2008

Effects of Simvastatin on Mandibular Distraction Osteogenesis

  • Erdem Kılıç, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Oral and Maxillofacial Surgery, Dental School, Erciyes University, Kayseri, Turkey
    • ,
  • İlker Özeç, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Oral and Maxillofacial Surgery, Dental School, Cumhuriyet University, Sivas, Turkey
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Özeç: Cumhuriyet Üniversitesi, Dişhekimliği Fakültesi, ADÇH ve Cerrahisi AD, 58140, Sivas, Turkey
    • ,
  • Hasan Yeler, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Dental School, Cumhuriyet University, Sivas, Turkey
    • ,
  • Adnan Korkmaz, MD

      Affiliations

    • Professor, Department of Histology and Embryology, Medical School, Ondokuz Mayıs University, Samsun, Turkey
    • ,
  • Bülent Ayas, MD

      Affiliations

    • Assistant Professor, Department of Histology and Embryology, Medical School, Ondokuz Mayıs University, Samsun, Turkey
    • ,
  • Cesur Gümüş, MD

      Affiliations

    • Assistant Professor, Department of Radiology, Medical School, Cumhuriyet University, Sivas, Turkey

References 

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  2. Yazawa M, Kishi K, Nakajima H, et al. Expression of bone morphogenetic proteins during mandibular distraction osteogenesis in rabbits. J Oral Maxillofac Surg. 2003;61:587
  3. Sojo K, Sawaki Y, Hattori H, et al. Immunohistochemical study of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2, -4 (BMP-2, -4) on lengthened rat femurs. J Craniomaxillofac Surg. 2005;33:238
  4. Knabe C, Nicklin S, Yu Y, et al. Growth factor expression following clinical mandibular distraction osteogenesis in humans and its comparison with existing animal studies. J Craniomaxillofac Surg. 2005;33:361
  5. Özeç İ, Öztürk M, Kılıç E, et al. Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction osteogenesis. J Craniofac Surg. 2006;17:80
  6. Yonezawa H, Harada K, Ikebe T, et al. Effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone consolidation on distraction osteogenesis: A preliminary study in rabbit mandibles. J Craniomaxillofac Surg. 2006;34:270
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  9. Farhadieh RD, Gianoutsos MP, Yu Y, et al. The role of bone morphogenetic proteins BMP-2 and BMP-4 and their related postreceptor signaling system (Smads) in distraction osteogenesis of the mandible. J Craniofac Surg. 2004;15:714
  10. Cho BC, Moon JH, Chung HY, et al. The bone regenerative effect of growth hormone on consolidation in mandibular distraction osteogenesis of a dog model. J Craniofac Surg. 2003;14:417
  11. Farhadieh RD, Dickinson R, Yu Y, et al. The role of transforming growth factor-beta, insulin-like growth factor I, and basic fibroblast growth factor in distraction osteogenesis of the mandible. J Craniofac Surg. 1999;10:80
  12. Sato M, Ochi T, Nakase T, et al. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. J Bone Miner Res. 1999;14:1084
  13. Zheng LW, Wong MC, Rabie AB, et al. Evaluation of recombinant human bone morphogenetic protein-2 in mandibular distraction osteogenesis in rabbits: Effect of dosage and number of doses on formation of bone. Br J Oral Maxillofac Surg. 2006;44:487
  14. Wong RW, Rabie AB. Early healing pattern of statin-induced osteogenesis. Br J Oral Maxillofac Surg. 2005;43:46
  15. Wong RW, Rabie AB. Histologic and ultrastructural study on statin graft in rabbit skulls. J Oral Maxillofac Surg. 2005;63:1515
  16. Sirola J, Honkanen R, Kroger H, et al. Relation of statin use and bone loss: A prospective population-based cohort study in early postmenopausal women. Osteoporos Int. 2002;13:537
  17. Skoglund B, Forslund C, Aspenberg P. Simvastatin improves fracture healing in mice. J Bone Miner Res. 2002;17:2004
  18. Montagnani A, Gonnelli S, Cepollaro C, et al. Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: A 1-year longitudinal study. Bone. 2003;32:427
  19. Gutierrez GE, Lalka D, Garrett IR, et al. Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations. Osteoporos Int. 2006;17:1033
  20. Thylin MR, McConnell JC, Schmid MJ, et al. Effects of simvastatin gels on murine calvarial bone. J Periodontol. 2002;73:114
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  22. Wong RW, Rabie AB. Statin collagen grafts used to repair defects in the parietal bone of rabbits. Br J Oral Maxillofac Surg. 2003;41:244
  23. Özeç İ, Kılıç E, Gümüş C, et al. Effect of local simvastatin application on mandibular defects. J Craniofac Surg. 2007;18:546
  24. Maeda T, Kawane T, Horiuchi N. Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation. Endocrinology. 2003;144:681
  25. Russell RG, Rogers MJ. Bisphosphonates: From the laboratory to the clinic and back again. Bone. 1999;25:97
  26. Hughes A, Rogers MJ, Idris AI, et al. A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo. Calcif Tissue Int. 2007;81:403
  27. Staal A, Frith JC, French MH, et al. The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity. J Bone Miner Res. 2003;18:88

PII: S0278-2391(08)00937-3

doi: 10.1016/j.joms.2008.05.362

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 11 , Pages 2233-2238 , November 2008

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