Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 10 , Pages 2004-2011 , October 2008

Determination of Potential Cellular Proliferation in the Odontogenic Epithelia of the Dental Follicle of the Asymptomatic Impacted Third Molars

  • Fatih Cabbar, DDS, MSc

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Yeditepe, Istanbul, Turkey
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Cabbar: Yeditepe University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Bagdat Cad. No:238 Goztepe, 34728 Istanbul, Turkey
  • ,
  • Nurhan Güler, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Yeditepe, Istanbul, Turkey
  • ,
  • Nil Comunoğlu, MD

      Affiliations

    • Associate Professor, Department of Pathology, Faculty of Medicine, University of Yeditepe, Istanbul, Turkey
  • ,
  • Kemal Şençift, DDS, PhD

      Affiliations

    • Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Yeditepe, Istanbul, Turkey
  • ,
  • Sedat Çöloğlu, MD

      Affiliations

    • Professor, Department of Pathology, Faculty of Medicine, University of Yeditepe, Istanbul, Turkey

References 

  1. NIH consensus development conference for removal of third molars. J Oral Surg. 1980;38:235
  2. Rawlins M. In pursuit of quality: The National Institute for Clinical Excellence. Lancet. 1999;353:1079
  3. Aldelsperger J, Campbell JH, Coates DB, et al. Early soft tissue pathosis associated with impacted third molars without pericoronal radiolucency. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89:402
  4. Glosser JW, Campbell JH. Pathologic change in soft tissues associated with radiographically “normal” third molar impactions. Br J Oral Maxillofac Surg. 1999;37:259
  5. Güven O, Keskin A, Akal ÜK. The incidence of cysts and tumors around impacted third molars. Int J Oral Maxillofac Surg. 2000;29:131
  6. Saraçoğlu U, Kurt B, Günhan Ö, et al. MIB-1 expression in odontogenic epithelial rests, epithelium of healthy oral mucosa and epithelium of selected odontogenic cysts (An immunohistochemical study). Int J Oral Maxillofac Surg. 2005;34:432
  7. Li TJ, Browne RM, Mathews JB. Expression of epidermal growth factor receptors by odontogenic jaw cysts. Virchows Arch. 1993;423:137
  8. Paula AMB, Carvalhais JN, Dominiques MG, et al. Cell proliferation markers in the odontogenic keratocysts: Effect of inflammation. J Oral Pathol Med. 2000;29:477
  9. Eliasson S, Heimdahl A, Nordenram A. Pathological changes related to long-term impaction of third molars. Int J Oral Maxillofac Surg. 1989;18:210
  10. Todorov IT, Werness BA, Wang HQ, et al. HsMCM2/BM28: A novel proliferation marker for human tumors and normal tissues. Lab Invest. 1998;78:73
  11. Tan DF, Huberman JA, Hyland A, et al. MCM2-a promising marker for premalignant lesions of the lung: A cohort study. BMC Cancer. 2001;1:6
  12. Macluskey M, Ogden GR, Gren M, et al. The association between epithelial proliferation and disease progression in the oral mucosa. Oral Oncol. 1999;35:409
  13. Hall PA, Woods AL. Immunohistochemical markers of cellular proliferation: Achievements, problems and prospects. Cell Tissue Kinet. 1990;23:505
  14. Kearsey SE, Labib K. MCM proteins: Evolution, properties, and role in DNA replication. Biochim Biophys Acta. 1998;1398:113
  15. Tye BK. MCM proteins in DNA replication. Methods. 1999;18:329
  16. Freeman A, Morris LS, Mills AD, et al. Mini-chromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res. 1999;5:2121
  17. Meng MV, Grossfeld GD, Williams GH, et al. Mini-chromosome maintenance protein 2 expression in prostate: Characterization and association with outcome after therapy for cancer. Clin Cancer Res. 2001;7:2712
  18. Going JJ, Keith WN, Neilson L, et al. Aberrant expression of mini-chromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous esophageal epithelium and Barrett's mucosa. Gut. 2002;50:373
  19. Stoeber K, Halsall I, Freeman A, et al. Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine. Lancet. 1999;354:1524
  20. Takisawa H, Mimura S, Kubota Y. Eukaryotic DNA replication: From pre-replication complex to initiation complex. Curr Opin Cell Biol. 2000;12:690
  21. Kramer IRH, Pindborg JJ, Shear M. Histological Typing of Odontogenic Tumors. In: (ed 2). Berlin: Springer-Verlag; 1992;p. 35–36
  22. Shear M. Cysts of the Oral Regions. (ed 3). Oxford: Wright; 1992;
  23. Takeda Y, Oikawa Y, Furuya I, et al. Mucous and ciliated cell metaplasia in epithelial linings of odontogenic inflammatory and developmental cysts. J Oral Sci. 2005;2:77
  24. Curran AE, Damm DD, Drummond JF. Pathologically significant pericoronal lesions in adults: Histopathologic evaluation. J Oral Maxillofac Surg. 2002;60:613
  25. Wilson D, Walker M, Aurora N, et al. Ameloblastoma with mucous cell differentiation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:576
  26. Waldron CA, Koh ML. Central mucoepidermoid carcinoma of the jaws: Report of four cases with analysis of the literature and discussion of the relationship to mucoepidermoid, sialodontogenic, and glandular odontogenic cysts. J Oral Maxillofac Surg. 1990;48:871
  27. da Silva Baumgart C, da Silva Lauxen I, Filho MS, et al. Epidermal growth factor receptor distribution in pericoronal follicles: Relationship with the origin of odontogenic cysts and tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:240
  28. Matsumoto MA, Filho HN, Jorge FM, et al. Expression of cell cycle regulatory proteins in epithelial components of dental follicles. J Mol Histol. 2006;37:127
  29. Shear M. The aggressive nature of the odontogenic keratocyst: Is it a benign cystic neoplasm? (Part 2. Proliferation and genetic studies). Oral Oncol. 2002;38:323
  30. Edamatsu M, Kumamoto H, Ooya K, et al. Apoptosis-related factors in the epithelial components of dental follicles and dentigerous cysts associated with impacted third molars of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:17
  31. Warnakulasuriya KA, MacDonald DG. Epithelial cell kinetics in oral leukoplakia. J Oral Pathol Med. 1995;24:163
  32. Kotelnikov VM, Coon JS, Taylor S, et al. Proliferation of epithelia of noninvolved mucosa in patients with head and neck cancer. Head Neck. 1996;18:522
  33. Kato H, Miyazaki T, Fukai Y, et al. A new proliferation marker, mini-chromosome maintenance protein 2, is associated with aggressiveness in esophageal squamous cell carcinoma. J Surg Oncol. 2003;84:24
  34. Rodu B, Tate AL, Martinez MG. The implications of inflammation in odontogenic keratocysts. J Oral Pathol Med. 1987;16:518
  35. Rakprasitkul S. Pathologic changes in the pericoronal tissues of unerupted third molars. Quintessence Int. 2001;32:633
  36. Brunette DM. Cholera toxin and dibutyryl cyclic-AMP stimulate the growth of epithelial cells derived from epithelial rests from porcine periodontal ligament. Arch Oral Biol. 1984;29:303
  37. Ramnath N, Hernandez FJ, Tan DF, et al. MCM2 is an independent predictor of survival in patients with non-small-cell lung cancer. J Clin Oncol. 2001;19:4259
  38. Ananthanarayaman V, Deaton RJ, XJ Yang, et al. Alteration of proliferation and apoptotic markers in normal premalignant tissue associated with prostate cancer. BMC Cancer. 2006;6:73
  39. Rodins K, Cheale M, Coleman N, et al. Mini-chromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: Relationship to tumor dormancy and potential clinical utility. Clin Cancer Res. 2002;8:1075

 This study was supported by TUBITAK (grant no. 106S236 [SBAG-HD-159]).

PII: S0278-2391(08)01053-7

doi: 10.1016/j.joms.2008.06.011

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 10 , Pages 2004-2011 , October 2008