Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 10 , Pages 2042-2049 , October 2008

Effects of Alendronate on Rate of Distraction in Rabbit Mandibles

  • Umut Tekin, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Tekin: Ozanlar Sokak 6/1, 06600 Kurtulus, Ankara, Turkey
  • ,
  • Hakan H. Tüz, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey
  • ,
  • Ercüment Önder, DDS, PhD

      Affiliations

    • Specialist, Medical Center, Middle East Technical University, Ankara, Turkey
  • ,
  • Özkan Özkaynak, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey
  • ,
  • Petek Korkusuz, MD, PhD

      Affiliations

    • Associate Professor, Department of Histology and Embryology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

References 

  1. McCarthy JG, Schreiber J, Karp N, et al. Lengthening the human mandible by gradual distraction. Plast Reconstr Surg. 1992;89:1
  2. McCarthy JG. The role of distraction osteogenesis in the reconstruction of the mandible in unilateral craniofacial microsomia. Clin Plast Surg. 1994;21:625
  3. Troulis MJ, Padwa B, Kaban LB. Distraction osteogenesis: Past, present, and future. Facial Plast Surg. 1998;14:205
  4. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues. Part 1. The influence of stability of fixation and soft tissue preservation. Clin Orthop. 1989;238:249
  5. Ilizarov GA. The tension-stress effect on the genesis and growth of tissues (Part 2. The influence of the rate and frequency of distraction). Clin Orthop. 1989;239:263
  6. Tsubota S, Tsuchiya H, Shinokawa Y, et al. Transplantation of osteoblast-like cells to the distracted callus in rabbits. J Bone Joint Surg Br. 1999;81:125
  7. Okazaki H, Kurokawa T, Nakamura K, et al. Stimulation of bone formation by recombinant fibroblast growth factor-2 in callotasis bone lengthening of rabbits. Calcif Tissue Int. 1999;64:542
  8. Raschke MJ, Bail H, Windhagen HJ, et al. Recombinant growth hormone accelerates bone regenerate consolidation in distraction osteogenesis. Bone. 1999;24:81
  9. Hagino T, Hamada Y. Accelerating bone formation and earlier healing after using demineralized bone matrix for limb lengthening in rabbits. J Orthop Res. 1999;17:232
  10. Al Ruhaimi KA. Effect of calcium sulphate on the rate of osteogenesis in distracted bone. Int J Oral Maxillofac Surg. 2001;30:228
  11. Kawamoto K, Kim WC, Tsuchida Y, et al. Effects of alternating current electrical stimulation on lengthening callus. J Pediatr Orthop [B]. 2005;14:299
  12. Eberson CP, Hogan KA, Moore DC, et al. Effect of low-intensity ultrasound stimulation on consolidation of the regenerate zone in a rat model of distraction osteogenesis. J Pediatr Orthop. 2003;23:46
  13. Little DG, Comell MS, Briody J, et al. Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis (A study in immature rabbits). J Bone Joint Surg Br. 2001;83:1069
  14. Russel RG, Roger MJ. Bisphosphonates: From the laboratory to the clinic and back again. Bone. 1999;25:97
  15. Tenenbaum HC, Shelemay A, Girard B, et al. Bisphosphonates and periodontics: Potential applications for regulation of bone mass in the periodontium and other therapeutic/diagnostic uses. J Periodontol. 2002;73:813
  16. Dunford JE, Thompson K, Coxon FP, et al. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001;296:235
  17. Lafage MH, Balene R, Battle MA, et al. Comparison of alendronate and sodium fluoride effect on cancellous and cortical bone in minipigs. J Clin Invest. 1995;95:2127
  18. Hughes DE, MacDonald BR, Russell RG, et al. Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow. J Clin Invest. 1989;83:1930
  19. Hughes DE, Wright KR, Uy HL, et al. Bisphosphonates promotes apoptosis in murine osteoclast in vitro and in vivo. J Bone Miner Res. 1995;10:1478
  20. Vitte C, Fleisch H, Guenthes HL. Bisphosphonates induce osteoblast to secrete an inhibitor of osteoclastic mediated resorption. Endocrinology. 1996;137:2324
  21. Sato M, Grasser W. Effects of bisphosphonates on isolated cat osteoclast as examined by reflected light microscopy. J Bone Miner Res. 1990;5:31
  22. Teronen O, Heikkila P, Konttinen YT, et al. MMP inhibition and down regulation by bisphosphonates. Ann NY Acad Sci. 1999;878:453
  23. Geddes AD, D'Souza SM, Ebetino FH, et al. Bisphosphonates: Structure-activity relationships and therapeutic implications. In:  Heersche JNM,  Kanis JA editor. Bone and Mineral Research. Amsterdam: Elsevier Science BV; 1994;p. 265–306
  24. In:  An YH,  Friedman RJ editor. Animal Models in Orthopedic Research. Boca Raton: CRC Press; 1999;p. 251–259
  25. Aronson J, Harrison BH, Stewart CL, et al. The histology of distraction osteogenesis using different external fixators. Clin Orthop. 1989;241:106
  26. Stewart KJ, McFarland LD, Weinhofer JJ, et al. Mandibular distraction osteogenesis: A comparison of distraction rates in the rabbit model. J Craniomaxillofac Surg. 1998;26:43
  27. Califano L, Cortese A, Zupi A, et al. Mandibular lengthening by external distraction: An experimental study in the rabbit. J Oral Maxillofac Surg. 1994;52:1179
  28. Goodship AE, Walker PC, McNally D, et al. Use of a bisphosphonate (pamidronate) to modulate fracture repair in ovine bone. Ann Oncol. 1994;5:53
  29. Von Knoch F, Jaquiery C, Kowalsky M. Effects of bisphosphonates on proliferation and osteoblast differentiation of human bone marrow stromal cells. Biomaterials. 2005;26:6941
  30. Im G, Qureshi SA, Kenney J, et al. Osteoblast proliferation and maturation by bisphosphonates. Biomaterials. 2004;25:4105
  31. Smith EJ, McEvoy A, Little DG, et al. Transient retention of endochondral cartilaginous matrix with bisphosphonate treatment in a long-term rabbit model of distraction osteogenesis. J Bone Miner Res. 2004;19:1698
  32. Pampu AA, Dolanmaz D, Tüz HH, et al. Experimental evaluation of the effects of zoledronic acid on regenerate bone formation and osteoporosis in mandibular distraction osteogenesis. J Oral Maxillofac Surg. 2006;64:1232
  33. Sen C, Gunes T, Erdem M, et al. Effects of calcitonin and alendronate on distraction osteogenesis. Int Orthop. 2006;30:272
  34. Li J, Mori S, Kaji Y, et al. Concentration of bisphosphonate (incadronate) in callus area and its effects on fracture healing in rats. J Bone Miner Res. 2000;15:2042
  35. Garcia-Moreno C, Serrano S, Nacher M, et al. Effect of alendronate on cultured normal human osteoblasts. Bone. 1998;22:233
  36. Ruggiero SL, Mehrotra B, Rosenberg TJ, et al. Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases. J Oral Maxillofac Surg. 2004;62:527

 This research was supported by Kırıkkale University Scientific Research Projects.

PII: S0278-2391(08)01088-4

doi: 10.1016/j.joms.2008.06.023

Journal of Oral and Maxillofacial Surgery
Volume 66, Issue 10 , Pages 2042-2049 , October 2008