Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 2 , Pages 273-279 , February 2009

Effects of Calcitonin Gene-Related Peptide on the Expression and Activity of Nitric Oxide Synthase During Mandibular Bone Healing in Rabbits: An Experimental Study

  • Yan Li, DDS

      Affiliations

    • Resident Surgeon, Department of Oral and Maxillofacial Surgery, Xingqiao Hospital, Third Military Medical University, Chongqing, People's Republic of China
    • ,
  • Yinghui Tan, DDS, PhD

      Affiliations

    • Professor and Chief Surgeon, Department of Oral and Maxillofacial Surgery, Xingqiao Hospital, Third Military Medical University, Chongqing, People's Republic of China
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Tan: Department of Oral and Maxillofacial Surgery, Xingqiao Hospital, Third Military Medical University, Chongqing 400037, PR China
    • ,
  • Gang Zhang, DDS, PhD

      Affiliations

    • Attending Surgeon and Lecturer, Department of Oral and Maxillofacial Surgery, Xingqiao Hospital, Third Military Medical University, Chongqing, People's Republic of China
    • ,
  • Bo Yang, DDS

      Affiliations

    • Attending Surgeon, Department of Oral and Maxillofacial Surgery, Chengdu Army General Hospital, Chengdu, People's Republic of China
    • ,
  • Jianshe Zhang, MD, DDS

      Affiliations

    • Professor and Chief Surgeon, Department of Oral and Maxillofacial Surgery, Chengdu Army General Hospital, Chengdu, People's Republic of China

References 

  1. Ma W, Chabot JG, Powell KJ, et al. Localization and modulation of calcitonin gene-related peptide-receptor component protein-immunoreactive cells in the rat central and peripheral nervous systems. Neuroscience. 2003;120:677
  2. Chang Y, Stover SR, Hoover DB. Regional localization and abundance of calcitonin gene-related peptide receptors in guinea pig heart. Mol Cell Cardiol. 2001;33:745
  3. Kawasaki H. Regulation of vascular function by perivascular calcitonin gene-related peptide-containing nerves. Jpn J Pharmacol. 2002;88:39
  4. Isaacson LG, Ondris D, Crutcher KA. Plasticity of mature sensory cerebrovascular axons following intracranial infusion of nerve growth factor. Comp Neurol. 1995;361:451
  5. Harty RF, Ancha HR, Xia Y, et al. Chemical sympathectomy-induced changes in TH-, VIP-, and CGRP-immunoreactive fibers in the rat mandible periosteum: Influence on bone resorption. Cell Physiol. 2003;194:341
  6. Offley SC, Guo TZ, Wei T, et al. Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity. J Bone Miner Res. 2005;20:257
  7. Villa I, Melzi R, Pagani F, et al. Effects of calcitonin gene-related peptide and amylin on human osteoblast-like cells proliferation. J Pharmacol. 2000;409:273
  8. Van TH, Ralston SH. Nitric oxide and bone. J Immunol. 2001;103:255
  9. Thakor AS, Giussani DA. Role of nitric oxide in mediating in vivo vascular responses to calcitonin gene-related peptide in essential and peripheral circulations in the fetus. Circulation. 2005;112:2510
  10. Jones KB, Mollano AV, Morcuende JA, et al. Bone and brain: A review of neural, hormonal, and musculoskeletal connections. Iowa Orthop J. 2004;24:123
  11. Onuoha GN. Circulating sensory peptide levels within 24 h of human bone fracture. Peptides. 2001;22:1107
  12. Lerner UH. Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone. J Musculoskelet Neuronal Ineract. 2006;6:81
  13. Lagumdzija A, Ou G, Petersson M, et al. Inhibited anabolic effect of insulin-like growth factor-I on stromal bone marrow cells in endothelial nitric oxide synthase-knockout mice. Acta Physiol Scand. 2004;182:29
  14. Zhu W, Murrell GA, Lin J, et al. Localization of nitric oxide synthases during fracture healing. J Bone Miner Res. 2002;17:1470
  15. Corbett SA, Hukkanen M, Batten J, et al. Differential localization expression and activity of nitric oxide synthases. Bone Joint Surg. 1999;819:531
  16. Mancini L, Moradi-Bidhendi N, Becherini L, et al. The biphasic effects of nitric oxide in primary rat osteoblasts are cGMP dependent. Biochem Biophys Res Commun. 2000;274:477
  17. Vincent AM, Feldman EL. Control of cell survival by IGF signaling pathways. Growth Horm IGF Res. 2002;12:193
  18. Armour KJ, Armour KE, vant H, et al. Activation of the inducible nitric oxide synthase pathway contributes to inflammation induced osteoporosis by suppressing bone formation and causing osteoblast apoptosis. Arthritis Rheum. 2001;44:2790

 This research was supported by a grant from the National Natural Science Foundation of China (No. 30772436).

PII: S0278-2391(08)01138-5

doi: 10.1016/j.joms.2008.06.077

Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 2 , Pages 273-279 , February 2009

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