Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 3 , Pages 471-476 , March 2009

Fluorescence-Guided Bone Resection in Bisphosphonate-Associated Osteonecrosis of the Jaws

  • Christoph Pautke, MD, DDS

      Affiliations

    • Consultant, Department of Oral and Cranio-Maxillofacial Surgery, Technische Universtität München, Munich, Germany
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Pautke: Department of Oral and Cranio-Maxillofacial Surgery, Technische Universtität München, Ismaninger Strasse 22, D-81675 Munich, Germany
    • ,
  • Florian Bauer, MD, DDS

      Affiliations

    • Resident, Department of Oral and Cranio-Maxillofacial Surgery, Technische Universtität München, Munich, Germany
    • ,
  • Thomas Tischer, MD

      Affiliations

    • Resident, Department of Orthopedic Surgery, Technische Universtität München, Munich, Germany
    • ,
  • Kilian Kreutzer, MD, DDS

      Affiliations

    • Resident, Department of Oral and Cranio-Maxillofacial Surgery, Technische Universtität München, Munich, Germany
    • ,
  • Jochen Weitz, MD, DDS

      Affiliations

    • Resident, Department of Oral and Cranio-Maxillofacial Surgery, Technische Universtität München, Munich, Germany
    • ,
  • Marco Kesting, MD, DDS

      Affiliations

    • Consultant, Department of Oral and Cranio-Maxillofacial Surgery, Technische Universtität München, Munich, Germany
    • ,
  • Frank Hölzle, MD, DDS

      Affiliations

    • Senior Consultant, Department of Oral and Cranio-Maxillofacial Surgery, Technische Universtität München, Munich, Germany
    • ,
  • Andreas Kolk, MD, DDS

      Affiliations

    • Senior Consultant, Department of Oral and Cranio-Maxillofacial Surgery, Technische Universtität München, Munich, Germany
    • ,
  • Stephen R. Stürzenbaum, PhD

      Affiliations

    • Senior Lecturer, Pharmaceutical Science Division, King's College London, London, England
    • ,
  • Klaus-Dietrich Wolff, MD, DDS

      Affiliations

    • Professor and Head of Department, Department of Oral and Cranio-Maxillofacial Surgery, Technische Universtität München, Munich, Germany

References 

  1. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic. J Oral Maxillofac Surg. 2003;61:1115
  2. Khosla S, Burr D, Cauley J, et al. Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2007;22:1479
  3. Ruggiero SL, Mehrotra B, Rosenberg TJ, et al. Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases. J Oral Maxillofac Surg. 2004;62:527
  4. Abu-Id MH, Warnke PH, Gottschalk J, et al. “Bis-phossy jaws”—High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. J Craniomaxillofac Surg. 2008;36:95
  5. Hess LM, Jeter JM, Benham-Hutchins M, et al. Factors associated with osteonecrosis of the jaw among bisphosphonate users. Am J Med. 2008;121:475
  6. Marx RE, Sawatari Y, Fortin M, et al. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: Risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005;63:1567
  7. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2007;65:369
  8. Grant BT, Amenedo C, Freeman K, et al. Outcomes of placing dental implants in patients taking oral bisphosphonates: A review of 115 cases. J Oral Maxillofac Surg. 2008;66:223
  9. Marx RE, Cillo JE, Ulloa JJ. Oral bisphosphonate-induced osteonecrosis: Risk factors, prediction of risk using serum CTX testing, prevention, and treatment. J Oral Maxillofac Surg. 2007;65:2397
  10. Engroff SL, Kim DD. Treating bisphosphonate osteonecrosis of the jaws: Is there a role for resection and vascularized reconstruction?. J Oral Maxillofac Surg. 2007;65:2374
  11. Hoff AO, Toth BB, Altundag K, et al. Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Miner Res. 2008;23:826
  12. Pautke C, Tischer T, Neff A, et al. In vivo tetracycline labeling of bone: An intraoperative aid in the surgical therapy of osteoradionecrosis of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:e10
  13. Hansen T, Kunkel M, Weber A, et al. Osteonecrosis of the jaws in patients treated with bisphosphonates—Histomorphologic analysis in comparison with infected osteoradionecrosis. J Oral Pathol Med. 2006;35:155
  14. Harvey BR, Ephros H, Defalco RJ. Tetracycline bone labeling in surgical management of chronic osteomyelitis: A case report. J Oral Maxillofac Surg. 2004;62:752
  15. Pautke C, Vogt S, Tischer T, et al. Polychrome labeling of bone with seven different fluorochromes: Enhancing fluorochrome discrimination by spectral image analysis. Bone. 2005;37:441
  16. Quereshy FA, Savell TA, Palomo JM. Applications of cone beam computed tomography in the practice of oral and maxillofacial surgery. J Oral Maxillofac Surg. 2008;66:791
  17. Svistun E, Alizadeh-Naderi R, El-Naggar A, et al. Vision enhancement system for detection of oral cavity neoplasia based on autofluorescence. Head Neck. 2004;26:205
  18. Lindsay R, Cosman F, Zhou H, et al. A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: Early actions of teriparatide. J Bone Miner Res. 2006;21:366
  19. Rauch F, Travers R, Glorieux FH. Cellular activity on the seven surfaces of iliac bone: A histomorphometric study in children and adolescents. J Bone Miner Res. 2006;21:513
  20. Dahners LE, Bos GD. Fluorescent tetracycline labeling as an aid to debridement of necrotic bone in the treatment of chronic osteomyelitis. J Orthop Trauma. 2002;16:345
  21. Lane PM, Gilhuly T, Whitehead P, et al. Simple device for the direct visualization of oral-cavity tissue fluorescence. J Biomed Opt. 2006;11:024006
  22. McCulloch CA, Birek P, Overall C, et al. Randomized controlled trial of doxycycline in prevention of recurrent periodontitis in high-risk patients: Antimicrobial activity and collagenase inhibition. J Clin Periodontol. 1990;17:616
  23. Ruhe JJ, Menon A. Tetracyclines as an oral treatment option for patients with community onset skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2007;51:3298
  24. Kolk A, Pautke C, Schott V, et al. Secondary post-traumatic enophthalmos: High-resolution magnetic resonance imaging compared with multislice computed tomography in postoperative orbital volume measurement. J Oral Maxillofac Surg. 2007;65:1926

PII: S0278-2391(08)01595-4

doi: 10.1016/j.joms.2008.09.037

Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 3 , Pages 471-476 , March 2009

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