Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 5, Supplement , Pages 75-84 , May 2009

Imaging Findings in Bisphosphonate-Related Osteonecrosis of Jaws

  • Kevin Arce, DMD, MD

      Affiliations

    • Assistant Professor and Program Director, Department of Oral and Maxillofacial Surgery, Oregon Health and Science University, Portland, OR
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Arce: Department of Oral and Maxillofacial Surgery, Oregon Health and Science University School of Dentistry, Mailcode SDOMS, 611 Southwest Campus Drive, Portland, OR 97239
    • ,
  • Leon A. Assael, DMD

      Affiliations

    • Professor and Chair, Department of Oral and Maxillofacial Surgery, Oregon Health and Science University, Portland, OR
    • ,
  • Jane L. Weissman, MD

      Affiliations

    • Professor and Director of Head and Neck Imaging, Departments of Diagnostic Radiology, Ophthalmology, and Otolaryngology, Oregon Health and Science University, Portland, OR
    • ,
  • Michael R. Markiewicz, DDS, MPH

      Affiliations

    • Resident in Training, Department of Oral and Maxillofacial Surgery, Oregon Health and Science University, Portland, OR

References 

  1. American Association of Oral and Maxillofacial Surgeons. Position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2007;65:369
  2. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic. J Oral Maxillofac Surg. 2003;61:1115
  3. Phal PM, Myall RW, Assael LA, et al. Imaging findings of bisphosphonate-associated osteonecrosis of the jaws. AJNR Am J Neuroradiol. 2007;28:1139
  4. Carneiro E, Vibhute P, Montazem A, et al. Bisphosphonate-associated mandibular osteonecrosis. AJNR Am J Neuroradiol. 2007;27:1096
  5. Sprecher S, Steinberg R, Lichtenstein D, et al. Magnetic resonance imaging presentation of lytic Paget's disease of the cervical spine. J Bone Miner Res. 2002;17:1929
  6. Hirshberg A, Leibovich P, Buchner A. Metastatic tumors to the jawbones: Analysis of 390 cases. J Oral Pathol Med. 1994;23:337
  7. Bedogni A, Blandamura S, Lokmic Z, et al. Bisphosphonate-associated jawbone osteonecrosis: A correlation between imaging techniques and histopathology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:358
  8. Chiandussi S, Biasotto M, Dore F, et al. Clinical and diagnostic imaging of bisphosphonate-associated osteonecrosis of the jaws. Dentomaxillofac Radiol. 2006;35:236
  9. Ruggiero SL, Mehrotra B, Rosenberg TJ, et al. Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases. J Oral Maxillofac Surg. 2004;62:527
  10. Raje N, Woo SB, Hande K, et al. Clinical, radiographic, and biochemical characterization of multiple myeloma patients with osteonecrosis of the jaw. Clin Cancer Res. 2008;14:2387
  11. Sonis ST, Watkins BA, Lyng GD, et al. Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients. Oral Oncol. 2009;45:164
  12. Bianchi SD, Scoletta M, Cassione FB, et al. Computerized tomographic findings in bisphosphonate-associated osteonecrosis of the jaw in patients with cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:249
  13. Bisdas S, Chambron Pinho N, Smolarz A, et al. Biphosphonate-induced osteonecrosis of the jaws: CT and MRI spectrum of findings in 32 patients. Clin Radiol. 2008;63:71
  14. Unger E, Moldofsky P, Gatenby R, et al. Diagnosis of osteomyelitis by MR imaging. AJR Am J Roentgenol. 1988;150:605
  15. Saini A, Saifuddin A. MRI of osteonecrosis. Clin Radiol. 2004;59:1079
  16. Ariji Y, Izumi M, Gotoh M, et al. MRI features of mandibular osteomyelitis: Practical criteria based on an association with conventional radiography features and clinical classification. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:503
  17. Garcia-Ferrer L, Bagan JV, Martinez-Sanjuan V, et al. MRI of mandibular osteonecrosis secondary to bisphosphonates. AJR Am J Roentgenol. 2008;190:949
  18. Tucker F. The use of radioactive phosphorus in the diagnosis of avascular necrosis of the femoral head. J Bone Joint Surg. 1950;32:100
  19. Schauwecker DS. The scintigraphic diagnosis of osteomyelitis. AJR Am J Roentgenol. 1992;158:9
  20. Horger M, Eschmann SM, Pfannenberg C, et al. Evaluation of combined transmission and emission tomography for classification of skeletal lesions. AJR Am J Roentgenol. 2004;183:655
  21. Catalano L, Del Vecchio S, Petruzziello F, et al. Sestamibi and FDG-PET scans to support diagnosis of jaw osteonecrosis. Ann Hematol. 2007;86:415
  22. Ho L, Quan V, Henderson R. Zoledronate-related osteonecrosis of the mandible. Clin Nucl Med. 2008;33:68

 Drs Arce, Weissman, and Markiewicz state no financial arrangement or affiliation with a corporate organization or a manufacturer of a product discussed in this article. Dr Assael is a paid consultant for Novartis and has received honoraria from Novartis and Merck.

PII: S0278-2391(08)01828-4

doi: 10.1016/j.joms.2008.12.002

Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 5, Supplement , Pages 75-84 , May 2009

Article Tools

* Image Usage & Resolution