Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 5 , Pages 951-956 , May 2009

CD34 Staining Density Predicts Giant Cell Tumor Clinical Behavior

  • Srinivas M. Susarla, DMD, MPH

      Affiliations

    • Resident, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Susarla: Oral and Maxillofacial Surgery, Massachusetts General Hospital, 55 Fruit Street, Warren 1201, Boston, MA 02114
    • ,
  • Meredith August, DMD, MD

      Affiliations

    • Associate Professor, Oral and Maxillofacial Surgery, Massachusetts General Hospital, and Harvard School of Dental Medicine, Boston, MA
    • ,
  • Nathan Dewsnup, DMD

      Affiliations

    • Formerly, DMD Candidate, Harvard School of Dental Medicine, Boston, MA
    • ,
  • William C. Faquin, MD, PhD

      Affiliations

    • Associate Professor, Pathology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA
    • ,
  • Leonard B. Kaban, DMD, MD

      Affiliations

    • Walter C. Guralnick Professor and Chairman, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, and Harvard School of Dental Medicine, Boston, MA
    • ,
  • Thomas B. Dodson, DMD, MPH

      Affiliations

    • Director, Center for Applied Clinical Investigation, and Visiting Oral and Maxillofacial Surgeon, Massachusetts General Hospital, and Associate Professor, Harvard School of Dental Medicine, Boston, MA

References 

  1. Chuong R, Kaban LB, Kozakewich H, et al. Giant cell lesions of the the jaws: A clinicopathologic study. J Oral Maxillofac Surg. 1986;44:708
  2. Kruse-Losler B, Diallo R, Gaertner C, et al. Central giant cell granuloma of the jaws: A clinical, radiologic, and histopathologic study of 26 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:346
  3. Auclair PL, Cuenin P, Kratochvil FJ, et al. A clinical and histomorphologic comparison of the central giant cell granuloma and the giant cell tumor. Oral Surg Oral Med Oral Pathol. 1988;66:197
  4. Waldron CA, Shafer WG. The central giant cell reparative granuloma of the jaws: An analysis of 38 cases. Am J Clin Pathol. 1966;45:437
  5. Eisenbud L, Stern M, Rothberg M, et al. Central giant cell granuloma of the jaws: Experiences in the management of thirty-seven cases. J Oral Maxillofac Surg. 1988;46:376
  6. Sidhu MS, Parkash H, Sidhu SS. Central giant cell granuloma of jaws—Review of 19 cases. Br J Oral Maxillofac Surg. 1995;33:43
  7. Kaban LB, Troulis MJ, Ebb D, et al. Antiangiogenic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg. 2002;60:1103
  8. Vered M, Buchner D, Dayan D. Giant cell granuloma of the jawbones—A proliferative vascular lesion? (Immunohistochemical study with vascular endothelial growth factor and basic fibroblast growth factor). J Oral Pathol Med. 2006;35:613
  9. Kaban LB, Mulliken JB, Ezekowitz A, et al. Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with Interferon alpha-2a. Pediatrics. 1999;103:1145
  10. O'Malley M, Pogrel MA, Stewart JC, et al. Central giant cell granulomas of the jaws: Phenotype and proliferation-associated markers. J Oral Pathol Med. 1997;26:159
  11. Kaban LB, Troulis MJ, Wilkinson MJ, et al. Adjuvant antiangiogenic therapy for giant cell tumors of the jaws. J Oral Maxillofac Surg. 2007;65:2018
  12. Eckardt A, Pogrel MA, Kaban LB, et al. Central giant cell granulomas of the jaws (Nuclear DNA analysis using image cytometry). Int J Oral Maxillofac Surg. 1989;18:3
  13. Dewsnup NC, Susarla SM, Abulikemu M, et al. Immunohistochemical evaluation of giant cell tumors of the jaws using CD34 density analysis. J Oral Maxillofac Surg. 2008;66:928
  14. Schultze-Mosgau S, Holbach LM, Wiltfang J. Cherubism: clinical evidence and therapy. J Craniofac Surg. 2003;14:201
  15. Nguyen M, Watanabe H, Budson AE, et al. Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J Natl Cancer Inst. 1994;86:356

 This study was supported by the Massachusetts General Hospital Department of Oral and Maxillofacial Surgery Education and Research Fund (S.M.S., N.D.) and the Oral and Maxillofacial Surgery Foundation Fellowship in Clinical Investigation (S.M.S.).

PII: S0278-2391(09)00056-1

doi: 10.1016/j.joms.2008.12.045

Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 5 , Pages 951-956 , May 2009

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