Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 7 , Pages 1363-1372 , July 2009

Intravenous Bisphosphonate-Related Osteonecrosis of the Jaw: Bone Scintigraphy as an Early Indicator

  • Felice S. O'Ryan, DDS

      Affiliations

    • Director, Division of Maxillofacial Surgery, Kaiser Permanente Oakland Medical Center, Oakland, CA
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr O'Ryan: Division of Maxillofacial Surgery, Kaiser Permanente, 280 W MacArthur Blvd, Oakland, CA 94611
    • ,
  • Sam Khoury, DMD

      Affiliations

    • Resident, Department of Oral and Maxillofacial Surgery, Highland General Hospital, and Division of Maxillofacial Surgery, Kaiser Permanente Oakland Medical Center, Oakland, CA
    • ,
  • Wendy Liao, DDS

      Affiliations

    • Former Resident, Department of Oral and Maxillofacial Surgery, Highland General Hospital, Oakland, CA; and Currently, Private Practice, San Francisco, CA
    • ,
  • Myo M. Han, MD

      Affiliations

    • Associate Physician, Department of Nuclear Medicine, Kaiser Permanente East Bay Medical Center, Oakland, CA
    • ,
  • Rita L. Hui, PharmD, MS

      Affiliations

    • Pharmacist, Pharmacy Outcomes Research Group, Drug Information Services, Kaiser Permanente Northern California, Oakland, CA
    • ,
  • David Baer, MD

      Affiliations

    • Chief, Department of Oncology, Kaiser Permanente Medical Center Oakland/Richmond, Oakland, CA
    • ,
  • Daniel Martin, DDS

      Affiliations

    • Resident, Division of Oral and Maxillofacial Surgery, Alameda County Medical Center/University of the Pacific School of Dentistry, Oakland, CA
    • ,
  • Donald Liberty, DDS

      Affiliations

    • Chief, Division of Maxillofacial Surgery, Department of Head and Neck Surgery, Kaiser Permanente South Sacramento Medical Center, Sacramento, CA
    • ,
  • Joan C. Lo, MD

      Affiliations

    • Research Scientist, Division of Research, Kaiser Permanente Northern California, Oakland, CA

References 

  1. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic. J Oral Maxillofac Surg. 2003;61:1115
  2. Migliorati CA. Bisphosphanates and oral cavity avascular bone necrosis. J Clin Oncol. 2003;22:4253
  3. Ruggiero SL, Mehrotra B, Rosenberg TJ, et al. Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases. J Oral Maxillofac Surg. 2004;62:527
  4. Bamias A, Kastritis E, Bamia C, et al. Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: Incidence and risk factors. J Clin Oncol. 2005;23:8580
  5. Dimopoulos MA, Kastritis E, Anagnostopoulos A, et al. Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: Evidence of increased risk after treatment with zoledronic acid. Haematologica. 2006;91:968
  6. Zervas K, Verrou E, Teleioudis Z, et al. Incidence, risk factors and management of osteonecrosis of the jaw in patients with multiple myeloma: A single-centre experience in 303 patients. Br J Haematol. 2006;134:620
  7. Reid IR. Osteonecrosis of the jaw—Who gets it, and why?. Bone. 2009;44:4
  8. Bisdas S, Chambron Pinho N, Smolarz A, et al. Bisphosphonate-induced osteonecrosis of the jaws: CT and MRI spectrum of findings in 32 patients. Clin Radiol. 2008;63:71
  9. Groetz KA, Al-Nawas B. Persisting alveolar sockets—A radiologic symptom of BP-ONJ?. J Oral Maxillofac Surg. 2006;64:1571
  10. Chiandussi S, Biasotto M, Dore F, et al. Clinical and diagnostic imaging of bisphosphonate-associated osteonecrosis of the jaws. Dentomaxillofac Radiol. 2006;35:236
  11. Phal PM, Myall RW, Assael LA, et al. Imaging findings of bisphosphonate-associated osteonecrosis of the jaws. AJNR Am J Neuroradiol. 2007;28:1139
  12. Abu-Id MH, Warnke PH, Gottschalk J, et al. “Bis-phossy jaws”—High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw. J Craniomaxillofac Surg. 2008;36:95
  13. Advisory Task Force on Bisphosphonate-Related Osteonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2007;65:369
  14. Vieillard MH, Maes JM, Penel G, et al. Thirteen cases of jaw osteonecrosis in patients on bisphosphonate therapy. Joint Bone Spine. 2008;75:34
  15. Kakhki VD, Zakavi SR. Age-related normal variants of sternal uptake on bone scintigraphy. Clin Nucl Med. 2006;31:63
  16. Pozzi S, Marcheselli R, Sacchi S, et al. Bisphosphonate-associated osteonecrosis of the jaw: A review of 35 cases and an evaluation of its frequency in multiple myeloma patients. Leuk Lymphoma. 2007;48:56
  17. Hoff AO, Toth BB, Altundag K, et al. Frequency and risk factors associated with osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates. J Bone Miner Res. 2008;23:826
  18. Hansen T, Kunkel M, Springer E, et al. Actinomycosis of the jaws—Histopathological study of 45 patients shows significant involvement in bisphosphonate-associated osteonecrosis and infected osteoradionecrosis. Virchows Arch. 2007;451:1009
  19. Zanglis A, Andreopoulos D, Dima M, et al. Jaw uptake of technetium-99 methylene diphosphonate in patients on bisphosphonates: A word of caution. J Hell Nucl Med. 2007;10:177
  20. Catalano L, Del Vecchio S, Petruzziello F, et al. Sestamibi and FDG-PET scans to support diagnosis of jaw osteonecrosis. Ann Hematol. 2007;86:415
  21. Reid IR, Cundy T. Osteonecrosis of the jaw. Skeletal Radiol. 2009;38:107
  22. Termaat MF, Raijmakers PG, Scholten HJ, et al. The accuracy of diagnostic imaging for the assessment of chronic osteomyelitis: A systematic review and meta-analysis. J Bone Joint Surg Am. 2005;87:2464

PII: S0278-2391(09)00292-4

doi: 10.1016/j.joms.2009.03.005

Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 7 , Pages 1363-1372 , July 2009

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