Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 7 , Pages 1378-1386 , July 2009

Osteoradionecrosis of the Mandible: Treatment Outcomes and Factors Influencing the Progress of Osteoradionecrosis

  • Hee-Kyun Oh, MS, PhD

      Affiliations

    • Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 2nd Stage of Brain Korea 21, Chonnam National University, Gwangju, South Korea
    • ,
  • Mark S. Chambers, DMD, MS

      Affiliations

    • Professor, Oncologic Dentistry and Prosthodontics, Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX
    • ,
  • Jack W. Martin, DDS, MS

      Affiliations

    • Professor, Oncologic Dentistry and Prosthodontics, Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX
    • ,
  • Hoi-Jeong Lim, PhD

      Affiliations

    • Assistant Professor, Department of Medical Statistics, School of Dentistry, Dental Science Research Institute, 2nd Stage of Brain Korea 21, Chonnam National University, Gwangju, South Korea
    • ,
  • Hong-Ju Park, MS, PhD

      Affiliations

    • Chairman and Associate Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 2nd Stage of Brain Korea 21, Chonnam National University, Gwangju, South Korea
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Park: Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, 2nd Stage of Brain Korea 21, Chonnam National University, 5, Hakdong, Donggu, Gwangju, 501-757, Republic of Korea

References 

  1. Marx RE. Osteoradionecrosis; a new concept of its pathophysiology. J Oral Maxillofac Surg. 1983;41:283
  2. Epstein JB, Wong FLW, Stevenson-Moore P. Osteoradionecrosis: Clinical experience and a proposal for classification. J Oral Maxillofac Surg. 1987;45:104
  3. Baker SR. Management of osteoradionecrosis of the mandible with myocutaneous flaps. J Surg Oncol. 1983;24:282
  4. Nakatsuka T, Harii K, Yamada A, et al. Surgical treatment of mandibular osteoradionecrosis: Versatility of the scapular osteocutaneous flap. Scand J Plast Reconstr Hand Surg. 1996;30:291
  5. Shaha AR, Cordeiro PG, Hidalgo DA, et al. Resection and immediate microvascular reconstruction in the management of osteoradionecrosis of the mandible. Head Neck. 1997;19:406
  6. Guttenberg SA. Osteoradionecrosis of the jaw. Am J Surg. 1974;127:326
  7. Beumer J, Harrison R, Sanders B, et al. Osteoradionecrosis: Predisposing factors and outcome of therapy. Head Neck Surg. 1984;6:819
  8. Aitasalo K, Niinikoski J, Grenman R, et al. A modified protocol for early treatment of osteomyelitis and osteoradionecrosis of the mandible. Head Neck. 1998;20:411
  9. Epstein J, Meij E, McKenzie M, et al. Postradiation osteonecrosis of the mandible: A long-term follow-up study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83:657
  10. Mickey J, Greenland S. A study of the impact of confounder selection criteria on effect estimation. Am J Epidemiol. 1989;129:125
  11. Kluth EV, Jain PR, Stuchell RN, et al. A study of factors contributing the development of osteoradionecrosis of the jaws. J Prosthet Dent. 1988;59:194
  12. Bedwinek J, Shukovsky L, Fletcher G, et al. Osteoradionecrosis in patients treated with definite radiotherapy for squamous cell carcinoma of the oral cavity and naso- and oropharynx. Radiology. 1976;119:665
  13. Murray CG, Daly TE, Zimmerman SO. The relationship between dental disease and radiation necrosis of the mandible. Oral Surg Oral Med Oral Pathol. 1980;49:99
  14. Sanger JR, Matloub HS, Yousif NJ, et al. Management of osteoradionecrosis of the mandible. Clin Plast Surg. 1993;20:517
  15. Santamaria E, Wei FC, Chen HC. Fibula osteoseptocutaneous flap for reconstruction of osteoradionecrosis of the mandible. Plast Reconstr Surg. 1998;101:921
  16. Koka VN, Deo R, Lusinchi A, et al. Osteoradionecrosis of the mandible: Study of 104 cases treated by hemimandibulectomy. J Laryngol Otol. 1990;104:305
  17. Obwegesser HL, Sailer HF. Experience with intraoral resection and immediate reconstruction in cases in radio-osteomyelitis of the mandible. J Maxillofac Surg. 1978;6:257

PII: S0278-2391(09)00313-9

doi: 10.1016/j.joms.2009.02.008

Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 7 , Pages 1378-1386 , July 2009

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