Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 11 , Pages 2354-2363 , November 2009

Role of p38 MAPK Pathway in Induction of iNOS Expression in Neutrophils and Peripheral Blood Mononuclear Cells in Patients With Squamous Cell Carcinoma of the Oral Cavity

  • Wioletta Ratajczak-Wrona, PhD

      Affiliations

    • Lecturer, Department of Immunology, Medical University of Bialystok, Bialystok, Poland
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Ratajczak-Wrona: Department of Immunology, Medical University of Bialystok, Waszyngtona 15A, Bialystok 15-269 Poland
    • ,
  • Ewa Jablonska, DSc

      Affiliations

    • Professor of Immunology, Department of Immunology, Medical University of Bialystok, Bialystok, Poland
    • ,
  • Magdalena Marcinczyk, PhD

      Affiliations

    • Assistant, Department of Immunology, Medical University of Bialystok, Bialystok, Poland
    • ,
  • Zyta Grabowska, DDS, DSc

      Affiliations

    • Professor of Stomatology, Department of Oral and Maxillofacial Surgery, Medical University of Bialystok, Bialystok, Poland
    • ,
  • Leszek Piotrowski, DDS

      Affiliations

    • Assistant, Department of Oral and Maxillofacial Surgery, Medical University of Bialystok, Bialystok, Poland

References 

  1. Velázquez RA, McGuff HS, Sycamore D, et al. The role of computed tomographic scans in the management of the N-positive neck in head and neck squamous cell carcinoma after chemoradiotherapy. Arch Otolaryngol Head Neck Surg. 2004;130:74
  2. Tremblay S, Pintor dos Reis P, Bradley G, et al. Young patients with oral squamous cell carcinoma: Study of the involvement of GSTP1 and deregulation of the Fanconi anemia genes. Arch Otolaryngol Head Neck Surg. 2006;132:958
  3. Mlynarek AM, Balys RL, Su J, et al. A cell proteomic approach for the detection of secretable biomarkers of invasiveness in oral squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2007;133:910
  4. Balkwil F, Mantovani A. Inflammation and cancer: Back to Virchow?. Lancet. 2001;357:539
  5. Di Carlo E, Forni G, Lollini P. The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood. 2001;97:339
  6. Beck KF, Eberhardt W, Frank S, et al. Inducible NO synthase: Role in cellular signaling. J Exp Biol. 1999;202:645
  7. Moodley YP. The role of inducible nitric oxide in health and disease. Curr Diagn Pathol. 2002;8:297
  8. Robbins RA, Grisham MB. Nitric oxide. Int J Biochem Cell Biol. 1997;29:857
  9. Alagol H, Erdem E, Sancak B, et al. Nitric oxide biosynthesis and malondialdehyde levels in advanced breast cancer. Aust N Z J Surg. 1999;69:647
  10. Bakan E, Taysi S, Polat MF, et al. Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer. Jpn J Clin Oncol. 2002;32:162
  11. Koesling D, Bohme E, Schultz G. Guanylyl cyclases, a growing family of signal-transducing enzymes. FASEB J. 1991;5:2785
  12. Stroop SD, Beavo JA. Structure and function studies of the cGMP-stimulated phosphodiesterase. J Biol Chem. 1991;266:23802
  13. Kroncke KD, Fehsel K, Kolb-Bachofen V. Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities. Biol Chem Hoppe Seyler. 1995;376:327
  14. Jablonska E, Puzewska W, Charkiewicz M. Effect of IL-18 on leukocyte expression of iNOS and phospho-IκB in patients with squamous cell carcinoma of the oral cavity. Neoplasma. 2006;53:200
  15. Jablonska E, Puzewska W, Marcinczyk M, et al. iNOS expression and NO production by neutrophils in cancer patients. Arch Immunol Ther Exp. 2005;53:175
  16. Jablonska E, Ratajczak W, Jablonski J. p38 MAPK pathway role in induction of iNOS expression in human leukocytes. Folia Biol. 2008;56:1
  17. Ono K, HanCell J. The p38 signal transduction pathway: Activation and function. Cell Signal. 2000;12:1
  18. Pearson G, Robinson F, Gibson TB, et al. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocr Rev. 2001;22:153
  19. Dong C, Davis RJ, Flavell RA. MAP kinases in the immune response. Annu Rev Immunol. 2002;20:55
  20. Lowenstein CJ, Padalko E. iNOS (NOS2) at a glance. J Cell Sci. 2004;117:2865
  21. Lee JC, Kumar S, Griswold DE, et al. Inhibition of p38 MAP kinase as a therapeutic strategy. J Immunopharmacol. 2000;47:185
  22. Olson JM, Hallahan AR. p38 MAP kinase: A convergence point in cancer therapy. Trends Mol Med. 2004;10:125
  23. Enslen H, Raingeaud J, Davis RJ. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem. 1998;273:1741
  24. American Joint Committee on Cancer: Manual for Staging of Cancer. ed 4. Philadelphia: JB Lippincott; 1992;
  25. Zeman K, Tchorzewski H, Majewska E. Simple and fast method of simultaneous isolation of lymphocytes and the polymorphonuclear cells from peripheral blood. Immunol Pl. 1988;13:217
  26. Schulz K, Kerber S, Kelm M. Reevaluation of the Griess method for determining NO/NO2− in aqueous and protein-containing samples. Nitric Oxide. 1999;3:225
  27. McCord JM, Fridovich I. The utility of superoxide dismutase in studying free radical reactions and radicals generated by the interaction of sulfite, dimethyl sulfoxide, and oxygen. J Biol Chem. 1969;244:6056
  28. Svingen BA, Buege JA, O'Neal FO, et al. The mechanism of NADPH-dependent lipid peroxidation: The propagation of lipid peroxidation. J Biol Chem. 1979;254:5892
  29. Da Silva J, Pierrat B, Mary JL, et al. Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric oxide synthase expression in mouse astrocytes. J Biol Chem. 1997;272:28373
  30. Chan ED, Riches DWH. IFN-γ + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38 MAPK in a mouse macrophage cell line. Am J Physiol Cell Physiol. 2001;280:C441
  31. Cavallo G, Sabadini L, Rollo L, et al. Nitric oxide synthesis in peripheral blood mononuclear and polymorphonuclear cells from patients with systemic sclerosis. Rheumatology. 1999;38:1301
  32. Rengasamy A, Johns RA. Regulation of nitric oxide synthase by nitric oxide. Mol Pharmacol. 1993;44:124
  33. Dembinska-Kiec A, Burchert M, Hartwich J. A neutrophil-derived NO-synthase (NOS) inhibitor. Agents Actions Suppl. 1995;45:163
  34. Vallance P, Leone A, Calver A, et al. Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol. 1992;20:60
  35. Welsh N. Interleukin-1β-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5FJ. Biol Chem. 1996;271:8307
  36. Jablonska E, Piotrowski L, Grabowska Z. Serum levels of IL-1β, IL-6, TNF-α, STNF-RI and CRP in patients with oral cavity cancer. Pathol Oncol Res. 1997;3:126
  37. Lahti A, Sareila O, Kankaanranta H, et al. Inhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: Implication in inducible nitric oxide synthase expression. BMC Pharmacol. 2006;6:5
  38. Gallo O, Gori AM, Attanasio M, et al. Interleukin-1beta and interleukin-6 release by peripheral blood monocytes in head and neck cancer. Br J Cancer. 1993;68:465
  39. Moilanen E, Vuorinen P, Kankaanranta H, et al. Inhibition by nitric oxide-donors of human polymorphonuclear leukocyte functions. Br J Pharmacol. 1993;109:852
  40. Marletta MA. Nitric oxide sythase: Aspects concerning structure and catalysis. Cell. 1994;78:927
  41. Clancy RM, Levartovsky D, Leszczynska-Piziak J, et al. Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: Evidence for S-nitrosoglutathione as a bioactive intermediary. Proc Natl Acad Sci USA. 1994;91:3680
  42. Xiao L, Nilsson CG, Eneroth PH. Cyclic guanosine 3′,5′-monophosphate mediates 3-morpholinosydnonimine-induced inhibition of human natural killer cells. Biochem Pharmacol. 1995;50:147
  43. Sundqvist T, Forslund T, Bengtsson T, et al. S-nitroso-N-acetylpenicillamine reduces leukocyte adhesion to type I collagen. Inflammation. 1994;18:625
  44. Ueta E, Osaki T, Yoneda K, et al. Influence of inductive chemoradiotherapy on salivary polymorphonuclear leukocyte (SPMN) functions in oral cancer. J Oral Pathol Med. 1994;23:418
  45. Ueta E, Osaki T, Yoneda K, et al. Functions of salivary polymorphonuclear leukocytes (SPMNs) and peripheral blood polymorphonuclear leukocytes (PPMNs) from healthy individuals and oral cancer patients. Clin Immunol Immunopathol. 1993;66:272
  46. Harada T, Obara S, Yoshimura Y. Superoxide anion generation from peripheral blood neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine in oromaxillary cancer patients. J Oral Maxillofac Surg. 1993;51:1013
  47. Hiramoto K, Ohkawa T, Oikawa N, et al. Is nitric oxide (NO) an antioxidant or a prooxidant for lipid peroxidation?. Chem Pharm Bull. 2003;51:1046
  48. Bigwood T, Read G. Pseudo malonaldehyde activity in the thiobarbituric acid test. Free Radic Res Commun. 1989;6:387
  49. Carbonneau MA, Peuchant E, Sess D, et al. Free and bound malondialdehyde measured as thiobarbituric acid adduct by HPLC in serum and plasma. Clin Chem. 1991;37:1423

PII: S0278-2391(09)00530-8

doi: 10.1016/j.joms.2009.04.030

Journal of Oral and Maxillofacial Surgery
Volume 67, Issue 11 , Pages 2354-2363 , November 2009

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