Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 3 , Pages 515-523 , March 2010

Effect of Zoledronic Acid on Osseointegration of Titanium Implants: An Experimental Study in an Ovariectomized Rabbit Model

  • Alper Yıldız, DDS, PhD

      Affiliations

    • Research Assistant, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Adana, Turkey
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Yildiz: Department of Oral and Maxillofacial Surgery, Çukurova University Faculty of Dentistry, Balcali, Adana, Turkey
    • ,
  • Emin Esen, DDS, PhD

      Affiliations

    • Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Adana, Turkey
    • ,
  • Mehmet Kürkçü, DDS, MSc, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Adana, Turkey
    • ,
  • İbrahim Damlar, DDS

      Affiliations

    • Research Assistant, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Çukurova University, Adana, Turkey
    • ,
  • Kenan Dağlıoğlu, PhD

      Affiliations

    • Veterinary Surgeon, The Experimental Surgery Center, School of Medicine, Çukurova University, Adana, Turkey
    • ,
  • Tolga Akova, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Prosthodontics, Faculty of Dentistry, Çukurova University, Adana, Turkey

References 

  1. Duarte PM, Cesar Neto JB, Goncalves PF, et al. Estrogen deficiency affects bone healing around titanium implants: A histometric study in rats. Implant Dent. 2003;12:340
  2. Branemark PI. Osseointegration and its experimental background. J Prosthet Dent. 1983;50:390
  3. Marco F, Milena F, Gianluca G, et al. Peri-implant osteogenesis in health and osteoporosis. Micron. 2005;36:630
  4. Qi MC, Zhou XQ, Hu J, et al. Estrogen replacement therapy promotes bone healing around dental implants in osteoporotic rats. Int J Oral Maxillofac Surg. 2004;33:279
  5. Duarte PM, de Vasconcelos Gurgel BC, Sallum AW, et al. Alendronate therapy may be effective in the prevention of bone loss around titanium implants inserted in estrogen-deficient rats. J Periodontol. 2005;76:107
  6. Gabet Y, Müller R, Levy J, et al. Parathyroid hormone 1-34 enhances titanium implant anchorage in low-density trabecular bone: A correlative micro-computed tomographic and biomechanical analysis. Bone. 2006;39:276
  7. Narai S, Nagahata S. Effects of alendronate on the removal torque of implants in rats with induced osteoporosis. Int J Oral Maxillofac Implants. 2003;18:218
  8. Kurth AH, Eberhardt C, Müller S, et al. The bisphosphonate ibandronate improves implant integration in osteopenic ovariectomized rats. Bone. 2005;37:204
  9. Peter B, Gauthier O, Laïb S, et al. Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats. J Biomed Mater Res A. 2006;76:133
  10. Owens G, Jackson R, Lewiecki EM. An integrating approach: Bisphosphonate management for the treatment of osteoporosis. Am J Manag Care. 2007;13:290
  11. Fleisch H. Bisphosphonates: Mechanisms of action. Endocr Rev. 1998;19:80
  12. Black DM, Delmas PD, Eastell R, et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med. 2007;356:1809
  13. Giro G, Sakakura CE, Gonçalves D, et al. Effect of 17beta-estradiol and alendronate on the removal torque of osseointegrated titanium implants in ovariectomized rats. J Periodontol. 2007;78:1316
  14. Yoshinari M, Oda Y, Inoue T, et al. Bone response to calcium phosphate-coated and bisphosphonate-immobilized titanium implants. Biomaterials. 2002;23:2879
  15. Peter B, Pioletti DP, Laïb S, et al. Calcium phosphate drug delivery system: Influence of local zoledronate release on bone implant osteointegration. Bone. 2005;36:52
  16. Erdoğan O, Shafer DM, Taxel P, et al. A review of the association between osteoporosis and alveolar ridge augmentation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:738
  17. Kanis JA, Melton LJ, Christiansen C, et al. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9:1137
  18. Yang J, Farnell D, Devlin H, et al. The effect of ovariectomy on mandibular cortical thickness in the rat. J Dent. 2005;33:123
  19. Cao T, Shirota T, Yamazaki M, et al. Bone mineral density in mandibles of ovariectomized rabbits. Clin Oral Implants Res. 2001;12:604
  20. Jonasson G, Bankvall G, Kiliaridis S. Estimation of skeletal bone mineral density by means of the trabecular pattern of the alveolar bone, its interdental thickness, and the bone mass of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:346
  21. Scully C, Madrid C, Bagan J. Dental endosseous implants in patients on bisphosphonate therapy. Implant Dent. 2006;15:212
  22. Fugazzotto PA, Lightfoot WS, Jaffin R, et al. Implant placement with or without simultaneous tooth extraction in patients taking oral bisphosphonates: Postoperative healing, early follow-up, and the incidence of complications in two private practices. J Periodontol. 2007;78:1664
  23. Grant BT, Amenedo C, Freeman K, et al. Outcomes of placing dental implants in patients taking oral bisphosphonates: A review of 115 cases. J Oral Maxillofac Surg. 2008;66:223
  24. Turner AS. Animal models of osteoporosis—Necessity and limitations. Eur Cell Mater. 2001;22:66
  25. Öberg S, Johansson C, Rosenquist JB. Bone formation after implantation of autolysed antigen extracted allogeneic bone in ovariectomized rabbits. Int J Oral Maxillofac Surg. 2003;32:628
  26. Arslan H, Ketani A, Gezici A, et al. The effects of osteoporosis on distraction osteogenesis: An experimental study in an ovariectomized rabbit model. Acta Orthop Belg. 2003;69:67
  27. Jung YC, Han CH, Lee IS, et al. Effects of ion beam-assisted deposition of hydroxyapatite on the osseointegration of endosseous implants in rabbit tibiae. Int J Oral Maxillofac Implants. 2001;16:809
  28. Meredith N, Shagaldi F, Alleyne D, et al. The application of resonance frequency measurements to study the implant stability of titanium implants during healing of the rabbit tibiae. Clin Oral Implants Res. 1997;8:234
  29. Rasmusson L, Meredith N, Sennerby L. Measurements of stability changes of titanium implants with exposed threads subjected to barrier membrane induced bone augmentation (An experimental study in the rabbit tibia). Clin Oral Implants Res. 1997;8:316
  30. Huang HM, Chiu CL, Yeh CY, et al. Early detection of implant healing process using resonance frequency analysis. Clin Oral Implants Res. 2003;14:437
  31. Sul YT, Johansson CB, Jeong Y, et al. Resonance frequency and removal torque analysis of implants with turned and anodized surface oxides. Clin Oral Implants Res. 2002;13:252
  32. Kürkcü M, Oz IA, Benlidayi ME. Effects of vitamin K(1) on fluoride-induced bone changes in growing rats: A histomorphometric and radiodensitometric study. Arch Oral Biol. 2005;50:889
  33. Cosman F, Herrington B, Himmelstein S, et al. Radiographic absorptiometry: A simple method for determination of bone mass. Osteoporos Int. 1991;2:34
  34. Gulam M, Thornton MM, Hodsman AB, et al. Bone mineral measurement of phalanges: Comparison of radiographic absorptiometry and area dual x-ray absorptiometry. Radiology. 2000;216:586
  35. Mori H, Manabe M, Kurachi Y, et al. Osseointegration of dental implants in rabbit bone with low mineral density. J Oral Maxillofac Surg. 1997;55:351
  36. Im GI, Qureshi SA, Kenney J, et al. Osteoblast proliferation and maturation by bisphosphonates. Biomaterials. 2004;25:4105
  37. Viereck V, Emons G, Lauck V, et al. Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. Biochem Biophys Res Commun. 2002;291:680
  38. Fromigué O, Body JJ. Bisphosphonates influence the proliferation and the maturation of normal human osteoblasts. J Endocrinol Invest. 2002;25:539
  39. Reinholz GG, Getz B, Pederson L, et al. Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts. Cancer Res. 2000;60:6001

 This study was partially supported by the Çukurova University scientific research fund and BioLok International and its representative in Turkey (UMG Uysal Medikal).

PII: S0278-2391(09)01478-5

doi: 10.1016/j.joms.2009.07.066

Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 3 , Pages 515-523 , March 2010

Article Tools

* Image Usage & Resolution