Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 5 , Pages 1013-1017 , May 2010

Felypressin, but Not Epinephrine, Reduces Myocardial Oxygen Tension After an Injection of Dental Local Anesthetic Solution at Routine Doses

  • Motoaki Inagawa, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan
    • Corresponding Author InformationAddress correspondence and reprint request to Dr Inagawa: 1-2-2 Masago, Mihama-ku, Chiba-city, Chiba, 261-8502, Japan
    • ,
  • Tatsuya Ichinohe, DDS, PhD

      Affiliations

    • Professor, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan
    • ,
  • Yuzuru Kaneko, DDS, PhD

      Affiliations

    • Professor and Chairman, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan

References 

  1. Yagiela JA. Vasoconstrictor agents for local anesthesia. Anesth Prog. 1995;42:116
  2. Anderson LD, Reagan SE. Local anesthetics and vasoconstrictors in patients with compromised cardiovascular systems. Gen Dent. 1993;4:161
  3. Ichinohe T, Kaneko Y, Nakakuki T. The effect of epinephrine on circulation and respiration: A study on epinephrine infusion technique. Dent Jpn. 1991;28:161
  4. Kaneko Y. Management of cardiovascular patients in the dental office. J Jpn Assoc Dent Sci. 1990;9:3
  5. Meechan JG, Parry G, Rattray DT, Thomason JM. Effects of dental local anaesthetics in cardiac transplant recipients. Br Dent J. 2002;192:161
  6. Ichinohe T, Igarashi O, Kaneko Y. The influence of propranolol on the cardiovascular effects and plasma clearance of epinephrine. Anesth Prog. 1991;38:217
  7. Jastak JT, Yagiela JA. Vasoconstrictors and local anesthesia: A review and rationale for use. J Am Dent Assoc. 1983;107:623
  8. Carrera R, Mestre L, Berini L, Gay-Escoda C. Alternations in monitored vital constants induced by various local anesthetics in combination with different vasoconstrictors in the surgical removal of lower third molars. Bull Groups Int Rech Sci Stomatol Odontal. 2000;42:1
  9. Bedi A, Carabine U. Peribulbar anaesthesia: A double-blind comparison of three local anaesthetic solutions. J Anesth. 1999;54:67
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  12. Kitagawa E, Kurozumi A, Tanaka K, et al. The effects of intravenous injection of felypressin on the regional myocardial oxygen balance in dogs with ischemic hearts. J Jpn Dent Soc Anesth. 1999;27:144
  13. Agata H, Ichinohe T, Kaneko Y. Felypressin-induced reduction in coronary blood flow and myocardial tissue oxygen tension during anaesthesia in dogs. Can J Anesth. 1999;46:1070
  14. Miyachi K, Ichinohe T, Kaneko Y. Effects of local injection of prilocaine-felypressin on the myocardial oxygen balance in dogs. Eur J Oral Sci. 2003;111:339
  15. Kitagawa E, Fukushima K. Effects of epinephrine on regional myocardial oxygen balance in the ischemic dog heart. Hokkaido J Dent Sci. 2003;24:108
  16. Troullos ES, Goldstein DS, Hargreaves KM, Dionne RA. Plasma epinephrine level and cardiovascular response to high administrated doses of epinephrine contained in local anesthesia. Anesth Analg. 1987;34:10
  17. Wade JG, Stevens WC. Isoflurane: An anesthetic for the eighties?. Anesth Analg. 1981;160:666
  18. Sunada K, Nakamura K, Yamashiro M, et al. Clinically safe dosage of felypressin for patients with essential hypertension. Anesth Prog. 1996;43:108
  19. Kitagawa E. The effects of intravenously injected felypressin on the cardiac function in dogs with intact or ischemic hearts. J Jpn Dent Soc Anesth. 1995;23:348
  20. Kasahara M, Ichinohe T, Kaneko Y. Adenosine and amrinone reverse felypressin-induced depression of myocardial tissue oxygen tension in dogs. Can J Anesth. 2000;47:1107
  21. Wali FA. Effects of local anaesthetics on responses of human saphenous vein and bovine coronary artery to neurotransmitters, acetylcholine, noradrenaline and 5-hydroxytryptamine. Gen Pharmacol. 1986;17:405
  22. Wiener L, Feola M, Templeton JY, et al. Monitoring tissue oxygenation of the heart after myocardial revascularization. Am J Cardiol. 1976;38:38
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  25. Guyton AC, Halla JE. Textbook of Medical Physiology. In: Philadelphia: WB Saunders; 1996;p. 253

 This study was partly supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PII: S0278-2391(09)01494-3

doi: 10.1016/j.joms.2009.07.080

Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 5 , Pages 1013-1017 , May 2010

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