Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 2 , Pages 260-267 , February 2010

Effect of Intermittent Systemic Administration of Recombinant Parathyroid Hormone (1-34) on Mandibular Fracture Healing in Rats

  • Henry H. Rowshan, DDS

      Affiliations

    • Formerly, Chief Resident, Department of Oral and Maxillofacial Surgery, Dwight David Eisenhower Army Medical Center, Fort Gordon, GA; and Currently, Chief, Oral and Maxillofacial Surgery, Ft Irwin, CA
    • ,
  • Mary A. Parham, DVM

      Affiliations

    • Chief of Veterinary Medicine, Department of Clinical Investigation, Dwight David Eisenhower Army Medical Center, Fort Gordon, GA
    • ,
  • Dale A. Baur, DDS, MD

      Affiliations

    • Associate Professor and Chair, Department of Oral and Maxillofacial Surgery, Case Western Reserve University, Cleveland, OH
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Baur: Department of Oral and Maxillofacial Surgery, Case Western Reserve University/University Hospitals, 2123 Abington Drive, Cleveland, OH 44106-4905
    • ,
  • RaeLynn D. McEntee, BBA

      Affiliations

    • Research Specialist, Department of Clinical Investigation, Dwight David Eisenhower Army Medical Center, Fort Gordon, GA
    • ,
  • Eugene Cauley

      Affiliations

    • Registered Animal Technician, Department of Clinical Investigation, Dwight David Eisenhower Army Medical Center, Fort Gordon, GA
    • ,
  • Dane T. Carriere

      Affiliations

    • Research Specialist, Department of Clinical Investigation, Dwight David Eisenhower Army Medical Center, Fort Gordon, GA
    • ,
  • Joseph C. Wood, PhD, MD

      Affiliations

    • Chief, Department of Clinical Investigation, Dwight David Eisenhower Army Medical Center, Fort Gordon, GA
    • ,
  • William J. Demsar, DMD, MS

      Affiliations

    • Chief of Oral and Maxillofacial Pathology, Department of Oral and Maxillofacial Surgery, Dwight David Eisenhower Army Medical Center, Fort Gordon, GA
    • ,
  • Jose M. Pizarro, MS, PhD

      Affiliations

    • Officer in Charge, Department of Clinical Investigation, Dwight David Eisenhower Army Medical Center, Fort Gordon, GA

References 

  1. James RB, Fredrickson C, Kent JN. Prospective study of mandibular fractures. J Oral Surg. 1981;39:275
  2. Campisi P, Hamdy RC, Lauzier D, et al. Expression of bone morphogenetic proteins during mandibular distraction osteogenesis. Plast Reconstr Surg. 2003;111:201
  3. Rowe NM, Mehrara BJ, Dudziak ME, et al. Rat mandibular distraction osteogenesis (Part I. Histologic and radiographic analysis). Plast Reconstr Surg. 1998;102:2022
  4. Steinbrech DS, Mehrara BJ, Rowe NM, et al. Gene expression of TGF-beta, TGF-beta receptor, and extracellular matrix proteins during membranous bone healing in rats. Plast Reconstr Surg. 2000;105:2028
  5. Arosarena OA, Collins WL. Defect repair in the rat mandible with bone morphogenic protein 5 and prostaglandin E1. Arch Otolaryngol Head Neck Surg. 2003;129:1125
  6. Eski M, Nisanci M, Cil Y, et al. A custom-made distraction device for experimental mandibular distraction osteogenesis. J Craniofac Surg. 2005;16:675
  7. Buchman SR, Ignelzi MA, Radu C, et al. Unique rodent model of distraction osteogenesis of the mandible. Ann Plast Surg. 2002;49:511
  8. Fukunaga T, Yamashiro T, Oya S, et al. Connective tissue growth factor mRNA expression pattern in cartilages is associated with their type I collagen expression. Bone. 2003;33:911
  9. Zheng L, Yamashiro T, Fukunaga T, et al. Bone morphogenetic protein 3 expression pattern in rat condylar cartilage, femoral cartilage and mandibular fracture callus. Eur J Oral Sci. 2005;113:318
  10. Childs SG. Stimulators of bone healing: Biologic and biomechanical. Orthop Nurs. 2003;22:421
  11. Oreffo RO. Growth factors for skeletal reconstruction and fracture repair. Curr Opin Investig Drugs. 2004;5:419
  12. Bolander ME. Regulation of fracture repair by growth factors. Proc Soc Exp Biol Med. 1992;200:165
  13. Chapman MW. Thoughts on clinical trials to evaluate the action and effectiveness of BMPs in bone healing. J Bone Joint Surg Am. 2001;83A(Suppl. 1):S163
  14. Nakajima A, Shimoji N, Shiomi K, et al. Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). J Bone Miner Res. 2002;17:2038
  15. Alkhiary YM, Gerstenfeld LC, Krall E, et al. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J Bone Joint Surg Am. 2005;87:731
  16. Rudman KE, Aspden RM, Meakin JR. Compression or tension? (The stress distribution in the proximal femur). Biomed Eng Online. 2006;5:12
  17. van Eijden TM. Biomechanics of the mandible. Crit Rev Oral Biol Med. 2000;11:123
  18. Holzer G, Majeska RJ, Lundy MW, et al. Parathyroid hormone enhances fracture healing: A preliminary report. Clin Orthop Relat Res. 1999;258:
  19. Neer RM, Arnaud CD, Zanchetta JR, et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344:1434
  20. Seebach C, Skripitz R, Andreassen TT, et al. Intermittent parathyroid hormone (1-34) enhances mechanical strength and density of new bone after distraction osteogenesis in rats. J Orthop Res. 2004;22:472
  21. Dobnig H, Turner RT. Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells. Endocrinology. 1995;136:3632
  22. Canalis E, Centrella M, Burch W, et al. Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures. J Clin Invest. 1989;83:60
  23. Canalis E, Pash J, Varghese S. Skeletal growth factors. Crit Rev Eukaryot Gene Expr. 1993;3:155
  24. Jilka RL, Weinstein RS, Bellido T, et al. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J Clin Invest. 1999;104:439
  25. Bellido T, Ali AA, Plotkin LI, et al. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts: A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem. 2003;278:50259
  26. Skripitz R, Aspenberg P. Parathyroid hormone—A drug for orthopedic surgery?. Acta Orthop Scand. 2004;75:654
  27. Bindels RJ, Dempster JA, Ramakers PL, et al. Effect of protein kinase C activation and downregulation on active calcium transport. Kidney Int. 1993;43:295
  28. Andreassen TT, Ejersted C, Oxlund H. Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures. J Bone Miner Res. 1999;14:960
  29. Abe N, Lee YP, Sato M, et al. Enhancement of bone repair with a helper-dependent adenoviral transfer of bone morphogenetic protein-2. Biochem Biophys Res Commun. 2002;297:523
  30. Vogelin MDE, Jones NF, Lieberman JR, et al. Prefabrication of bone by use of a vascularized periosteal flap and bone morphogenetic protein. Plast Reconstr Surg. 2002;109:190
  31. Lieberman JR, Daluiski A, Einhorn TA. The role of growth factors in the repair of bone: Biology and clinical applications. J Bone Joint Surg Am. 2002;84A:1032
  32. Williams JK, Rowe NM, Mackool RJ, et al. Controlled multiplanar distraction of the mandible (Part II: Laboratory studies of sagittal (anteroposterior) and vertical (superoinferior) movements). J Craniofac Surg. 1998;9:504
  33. Habener JF, Kronenberg HM. Parathyroid hormone biosynthesis: Structure and function of biosynthetic precursors. Fed Proc. 1978;37:2561
  34. Heinrich G, Kronenberg HM, Potts JT, et al. Parathyroid hormone messenger ribonucleic acid: Effects of calcium on cellular regulation in vitro. Endocrinology. 1983;112:449
  35. Hruska KA, Civitelli R, Duncan R, et al. Regulation of skeletal remodeling by parathyroid hormone. Contrib Nephrol. 1991;91:38
  36. Shirota T, Tashiro M, Ohno K, et al. Effect of intermittent parathyroid hormone (1-34) treatment on the bone response after placement of titanium implants into the tibia of ovariectomized rats. J Oral Maxillofac Surg. 2003;61:471
  37. Schwietert HR, Groen EW, Sollie FA, et al. Single-dose subcutaneous administration of recombinant human parathyroid hormone [rhPTH(1-84)] in healthy postmenopausal volunteers. Clin Pharmacol Ther. 1997;61:360

 This research was supported by internal funding from Southeast Regional Dental Command and Dental Activity and Dwight David Eisenhower Army Medical Center. The views of the authors do not purport to reflect the position of the Department of the Army or Department of Defense (paragraph 4-3), AR 360-5.

PII: S0278-2391(09)01749-2

doi: 10.1016/j.joms.2009.09.045

Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 2 , Pages 260-267 , February 2010

Article Tools

* Image Usage & Resolution