Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 3 , Pages 508-514, March 2010

Characteristics of Implant Failures in Patients With a History of Oral Bisphosphonate Therapy

  • Daniel C. Martin, DDS

      Affiliations

    • Former Resident, Division of Maxillofacial Surgery, Kaiser Permanente, Oakland Medical Center, Oakland, CA, and Department of Oral and Maxillofacial Surgery, Highland General Hospital, Oakland, CA; and Currently, Private Practice, Truckee, CA
    • ,
  • Felice S. O'Ryan, DDS

      Affiliations

    • Director, Division of Maxillofacial Surgery, Kaiser Permanente, Oakland Medical Center, Oakland, CA
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr O'Ryan: Kaiser Permanente Division of Maxillofacial Surgery, 280 W MacArthur Blvd, Oakland, CA 94611
    • ,
  • A. Thomas Indresano, DMD

      Affiliations

    • Chairman, Department of Oral and Maxillofacial Surgery, Highland General Hospital, Oakland, CA
    • ,
  • Pete Bogdanos

      Affiliations

    • Research Associate, Division of Research, Kaiser Permanente Northern California, Oakland, CA
    • ,
  • Benjamin Wang

      Affiliations

    • Research Intern, Division of Research, Kaiser Permanente Northern California, Oakland, CA
    • ,
  • Rita L. Hui, PharmD, MS

      Affiliations

    • Outcomes Research Scientist, Pharmacy Outcomes Research Group, Drug Information Services, Kaiser Permanente, California, Oakland, CA
    • ,
  • Joan C. Lo, MD

      Affiliations

    • Research Scientist and Senior Physician, Division of Research, Kaiser Permanente Northern California, Oakland, CA

Purpose

This study examines the pattern of implant failures reported in a large cohort of patients who received oral bisphosphonate therapy.

Materials and Methods

A total of 8,572 individuals who received oral bisphosphonate drugs returned a dental survey that obtained information pertaining to implant placement and related complications. Among the 589 individuals reporting dental implants, 16 reported implant failures that were verified by dental records. Implant placement, timing of failure, and bisphosphonate duration were ascertained to determine the characteristics of implant loss in the setting of oral bisphosphonate exposure.

Results

Among the 16 patients (all women, aged 70.2 ± 7.6 yrs) there were 26 implant failures; 8 had failure of 12 implants in the maxilla and 9 had failure of 14 implants in the mandible. Early failure (≤1 yr after placement) was experienced by 8 patients (8 implants), whereas late failures (>1 yr after placement) occurred in 10 patients (18 implants); 2 patients had both early and late failures.

Conclusions

Overall, few patients reported implant failures. However, among these, there were more late than early failures and a slightly higher proportion of failures in the mandible versus the maxilla. Further studies should investigate the role of chronic bisphosphonate therapy in implant survival and long-term implant osseointegration.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

 This study was funded by the US Food and Drug Administration (HHSF223200510008C), the National Institute of Child Health and Human Development at the National Institutes of Health (K12 HD052163), and the Kaiser Permanente Community Benefit Program. A portion of this study was also supported by the National Center for Research Resources at the National Institutes of Health (UCSF-CTSI UL1 RR024131). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the Food and Drug Administration or the National Institutes of Health.

PII: S0278-2391(09)01759-5

doi:10.1016/j.joms.2009.09.055

Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 3 , Pages 508-514, March 2010

Article Tools