Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 9 , Pages 2076-2084 , September 2010

Expression of TGF-β1, Osteonectin, and BMP-4 in Mandibular Distraction Osteogenesis With Compression Stimulation: Reverse Transcriptase-Polymerase Chain Reaction Study and Biomechanical Test

This study was presented at the 89th Annual Meeting of American Association of Oral and Maxillofacial Surgeons, Honolulu, Hawaii, 2007.

  • Uk-Kyu Kim, DDS, PhD

      Affiliations

    • Professor, Department of Oral and Maxillofacial Surgery, Pusan National University School of Dentistry, Pusan, Republic of Korea
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Kim: Department of Oral and Maxillofacial Surgery, Pusan National University Hospital, Amidong 1-10, Seogu, Pusan, South Korea
    • ,
  • Seong-Jin Park, DDS, MS

      Affiliations

    • Graduate Program Student, Pusan National University School of Dentistry, Pusan, Republic of Korea
    • ,
  • Wook-Jin Seong, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Restorative Sciences, University of Minnesota School of Dentistry, Minneapolis, MN
    • ,
  • Jun Heo, DDS, MS

      Affiliations

    • Graduate Program Student, Pusan National University School of Dentistry, Pusan, Republic of Korea
    • ,
  • Dae-Seok Hwang, DDS, PhD

      Affiliations

    • Clinical Assistant Professor, Department of Oral and Maxillofacial Surgery, Pusan National University Hospital, Pusan, Republic of Korea
    • ,
  • Yong-Deok Kim, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Pusan National University School of Dentistry, Pusan, Republic of Korea
    • ,
  • Sang-Hun Shin, DDS, PhD

      Affiliations

    • Professor, Department of Oral and Maxillofacial Surgery, Pusan National University School of Dentistry, Pusan, Republic of Korea
    • ,
  • Gyoo-Cheon Kim, PhD

      Affiliations

    • Associate Professor, Department of Oral Anatomy, Pusan National University School of Dentistry, Pusan, Republic of Korea

References 

  1. Greenwald JA, Luchs JS, Mehrara BJ, et al. “Pumping the tegenetate”: An evaluation of oscillating distraction osteogenesis in the rodent mandible. Ann Plast Surg. 2000;44:516
  2. Rsachke MJ, Bail H, Windhagen HJ, et al. Recombinant growth hormone accelerates bone regenerate consolidation in distraction osteogenesis. Bone. 1999;24:81
  3. Pepper JR, Herbert MA, Anderson JR, et al. Effect of capacitive coupled electrical stimulation on regenerate bone. J Orthop Res. 1996;14:296
  4. Mizumoto Y, Moseley T, Timothy BS, et al. Acceleration of regenerate ossification during distraction osteogenesis with the combinant human bone morphogenetic protein-7. J Bone Joint Surg Am. 2003;85:124
  5. Mofid MM, Inoue N, Atabey A, et al. Callus stimulation in distraction osteogenesis (Plast Reconstr). Surg. 2002;109:1620
  6. McCarthy JG, Schreiber J, Karp NS, et al. Lengthening the human mandible by gradual distraction. Plast Reconstr Surg. 1992;89:1
  7. Kunz C, Hammer B, Prein J. Manipulation of callus after linear distraction: A “lifeboat” or an alternative to multivectorial distraction osteogenesis of the mandible?. Plast Reconstr Surg. 2000;105:674
  8. Kim UK, Lee KH, Chung IK, et al. Mandibular distraction osteogenesis combination with compression stimulation. J Oral Maxillofac Surg. 2006;64:1498
  9. Hellio Le Graverand M-P, Reno C, Hart DA. Gene expression in menisci from knees of skeletally immature and mature female rabbits. Orthop Res. 1999;17:738
  10. Morone MA, Boden SD, Hair G. Gene expression during autograft lumbar spine fusion and the effect of bone morphogenetic protein 2. Clin Orthop. 1998;351:252
  11. Hiltunen A, Hannu TA, Vuorio E. Regulation of extracellular matrix genes during fracture healing. Clin Orthop. 1993;297:23
  12. Yasui N, Kojimoto H, Sasaki K, et al. Factors affecting callus distraction in limb lengthening. Clin Orthop. 1993;293:55
  13. Mehrara BJ, Rowe NM, Steinbrech DS, et al. Rat mandibular distraction osteogenesis: II, Molecular analysis of transforming growth factor beta 1 and osteocalcin gene expression. Plast Reconstr Surg. 1999;103:536
  14. Yates KE, Troulis MJ, Kaban LB, et al. IGF-1, TGF-β1, and BMP-4 are expressed during distraction osteogenesis of the pig mandible. Int J Oral Maxillofac Surg. 2002;31:173
  15. Delloye C, Delefortrie G, Coutelier L, et al. Bone regenerate formation in cortical bone during distraction lengthening: An experimental study. Clin Orthop. 1990;250:34
  16. White SH, Kenwright J. The timing of distraction of an osteotomy. J Bone Joint Surg Br. 1990;72:356
  17. Tavakoli K, Walsh WR, Bonar F, et al. The role of latency in mandibular osteodistraction. J Craniomaxillofac Surg. 1998;26:209
  18. Stewart KJ, Lvoff GO, White AS, et al. Mandibular distraction osteogenesis: A comparison of distraction rates in the rabbit model. J Craniomaxillofac Surg. 1998;26:43
  19. Li G, Berven S, Simpson H, et al. Expression of BMP-4 mRNA during distraction osteogenesis in rabbits. Acta Orthop Scand. 1998;69:42
  20. Rauch F, Lauzier D, Croteau S, et al. Temporal and spatial expression of BMP-2, -4 and -7 during distraction osteogenesis in rabbits. Bone. 2000;27:453
  21. Kim UK, Heo J, Hwang DS, et al. Optimal force ratio and application period for distraction with compression force. J Korean Maxillofac Plastic Recon Surg. 2005;27:403
  22. Riches PE, Everitt NM, Heggie AR, et al. Microhardness anisotropy of lamellar bone. J Biomech. 1997;30:1059
  23. Du C, Cui FZ, Feng QL, et al. Tissue response to nano-hydroxyapatite collagen composite implants in marrow cavity. J Biomed Mater Res. 1998;42:540
  24. Yeung HY, Lee KM, Fung KP, et al. Sustained expression of transforming growth factor-beta 1 by distraction during distraction osteogenesis in vitro. Life Sci. 2002;71:67
  25. Rowe NM, Mehrara BJ, Dudziak ME, et al. Rat mandibular distraction osteogenesis: Part I (Histologic and radiographic analysis). Plast Reconstr Surg. 1998;102:2022
  26. Eingartner C, Coerper S, Fritz J, et al. Growth factor in distraction osteogenesis—Immunohistological pattern of TGF-β1 and IGF-1 in human callus induced by distraction osteogenesis. Int Orthop. 1999;23:253
  27. Meyer U, Wiesmann HP, Kruse-Losler B, et al. Strain-related bone remodeling in distraction osteogenesis of the mandible. Plast Reconstr Surg. 1999;103:800
  28. Urist MR. Bone formation by autoinduction. Science. 1965;150:893
  29. Yazawa M, Kishi K, Nakajima H, et al. Expression of bone morphogenetic proteins during mandibular distraction osteogenesis in rabbits. J Oral Maxillofac Surg. 2003;61:587
  30. Farhadieh RD, Gianoutsos MP, Yu Y, et al. The role of bone morphogenic protein BMP-2 and BMP-4 and their related postreceptor signaling system (Smads) in distraction osteogenesis of the mandible. J Craniofac Surg. 2004;15:714
  31. Sato M, Ochi T, Nakase T, et al. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. J Bone Miner Res. 1999;14:1084
  32. Knabe C, Nicklin S, Yu Y, et al. Growth factor expression following clinical mandibular distraction osteogenesis in humans and its comparison with existing animal studies. J Craniomaxillofac Surg. 2005;33:361
  33. Campisi P, Hamdy RC, Lauzier D, et al. Expression of bone morphogenetic proteins during mandibular distraction osteogenesis. Plast Reconstr Surg. 2003;111:201

PII: S0278-2391(09)01812-6

doi: 10.1016/j.joms.2009.09.070

Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 9 , Pages 2076-2084 , September 2010

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