Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 5 , Pages 1018-1024 , May 2010

Analgesic and Anti-Inflammatory Effects of Oxaprozin and Naproxen Sodium After Removal of Impacted Lower Third Molars: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

Presented in part at the 15th International Congress of Turkish Association of Oral and Maxillofacial Surgery, Antalya, Turkey, October 29 - November 2, 2008.

  • İsa M. Kara, DDS, PhD

      Affiliations

    • Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Kara: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, 27310, Gaziantep, Turkey
    • ,
  • Serkan Polat, DDS, PhD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey
    • ,
  • Fatih İnce, MD

      Affiliations

    • Research Assistant, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey
    • ,
  • Cesur Gümüş, MD

      Affiliations

    • Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey

References 

  1. Laureano Filho JR, Maurette PE, Allais M, et al. Clinical comparative study of the effectiveness of two dosages of dexamethasone to control postoperative swelling, trismus and pain after the surgical extraction of mandibular impacted third molars. Med Oral Pathol Oral Cir Buccal. 2008;13:129
  2. Olmedo MV, Gálvez R, Vallecillo M. Double-blind parallel comparison of multiple doses of ketorolac, ketoprofen and placebo administered orally to patients with postoperative dental pain. Pain. 2001;90:135
  3. Pektas ZO, Sener M, Bayram B, et al. A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: A prospective, randomized, single-blind, crossover study. Int J Oral Maxillofac Surg. 2007;36:123
  4. Üstün Y, Erdoğan O, Esen E, et al. Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:535
  5. Markovic A, Todorovic Lj. Effectiveness of dexamethasone and low-power laser in minimizing oedema after third molar surgery: A clinical trial. Int J Oral Maxillofac Surg. 2007;36:226
  6. Jung YS, Kim MK, Um YJ, et al. The effects on postoperative oral surgery pain by varying NSAID administration times: Comparison on effect of preemptive analgesia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:559
  7. Benetello V, Sakamoto FC, Giglio FP, et al. The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal. Braz J Med Biol Res. 2007;40:1133
  8. Winter L, Post A. Double-blind comparison of single oral doses of oxaprozin, aspirin, and placebo for relief of post-operative oral surgery pain. J Int Med Res. 1983;11:308
  9. Dallegri F, Bertolotto M, Ottonello L. A review of the emerging profile of the anti-inflammatory drug oxaprozin. Expert Opin Pharmacother. 2005;6:777
  10. Davies NM. Clinical pharmacokinetics of oxaprozin. Clin Pharmacokinet. 1998;35:425
  11. Kethu SR, Rukkanagari S, Lansford CL. Oxaprozin-induced symptomatic hepatotoxicity. Ann Pharmacother. 1999;33:942
  12. Cooper SA, Itkin A, Zweig B. Comparison of oxaprozin, aspirin, and placebo in a dental impaction pain model. Adv Ther. 1992;9:184
  13. Bevilacqua M. Effect of oxaprozin and of other 2-arylpropionic acid derivatives on nuclear factor κB (NFκB) activation. Inflammopharmacology. 2002;10:173
  14. Heller B, Tarricone R. Oxaprozin versus diclofenac in NSAID-refractory periarthritis pain of the shoulder. Curr Med Res Opin. 2004;20:1279
  15. Huskisson EC, Weaver AL. Foreword. Inflammopharmacology. 2002;10:157
  16. Kean WF. Oxaprozin kinetic and dynamic profile in the treatment of pain. Curr Med Res Opin. 2004;20:1275
  17. Al-Khateeb T, Nusair Y. Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. Int J Oral Maxillofac Surg. 2008;37:264
  18. Calvo AM, Sakai VT, Giglio FP, et al. Analgesic and anti-inflammatory dose-response relationship of 7.5 and 15 mg meloxicam after lower third molar removal: A double-blind, randomized, crossover study. Int J Oral Maxillofac Surg. 2007;36:26
  19. Chang DJ, Fricke JR, Bird SR, et al. Rofecoxib versus codeine/acetaminophen in postoperative dental pain: A double-blind, randomized, placebo- and active comparator-controlled clinical trial. Clin Ther. 2001;23:1446
  20. Chiu WK, Cheung LK. Efficacy of preoperative oral rofecoxib in pain control for third molar surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:47
  21. Schultze-Mosgau S, Schmelzeisen R, Frölich JC, et al. Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars. J Oral Maxillofac Surg. 1995;53:2
  22. Ataoğlu H, Oz GY, Candirli C, et al. Routine antibiotic prophylaxis is not necessary during operations to remove third molars. Br J Oral Maxillofac Surg. 2008;46:133

PII: S0278-2391(09)01836-9

doi: 10.1016/j.joms.2009.09.094

Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 5 , Pages 1018-1024 , May 2010

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