Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 5 , Pages 1025-1031 , May 2010

Intranasal Ketorolac for Pain Secondary to Third Molar Impaction Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial

  • George M. Grant, DDS, PhD

      Affiliations

    • Private Practice, Austin Oral and Maxillofacial Surgery, Austin, TX
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr Grant: Austin Oral and Maxillofacial Surgery, 310 Stagecoach Trail, Suite 600, San Marcos, TX 78666
    • ,
  • Donald R. Mehlisch, MD, DDS

      Affiliations

    • President, Donald R. Mehlisch, MD, DDS, and Associates, The Woodlands, TX

References 

  1. Burke SM. Ketorolac: An alternative for the management of acute pain. MCN Am J Matern Child Nurs. 1997;22:56
  2. Gillis JC, Brogden RN. Ketorolac (A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management). Drugs. 1997;53:139
  3. Fricke JR, Angelocci D, Fox K, et al. Comparison of the efficacy and safety of ketorolac and meperidine in the relief of dental pain. J Clin Pharmacol. 1992;32:376
  4. Ong KS, Tan JM. Preoperative intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery. Int J Oral Maxillofac Surg. 2004;33:274
  5. Abbas SM, Kamal RS, Afshan G. Effect of ketorolac on postoperative pain relief in dental extraction cases—A comparative study with pethidine. J Pak Med Assoc. 2004;54:319
  6. Mehlisch DR, Desjardins PJ, Daniels S, et al. Single doses of parecoxib sodium intravenously are as effective as ketorolac in reducing pain after oral surgery. J Oral Maxillofac Surg. 2003;61:1030
  7. Wright G, Smith A. Intra-muscular ketorolac administered as a supplemental analgesic for removal of impacted third molar teeth: A prospective study. Aust Dent J. 2002;47:41
  8. Meechan JG, Seymour RA. The use of third molar surgery in clinical pharmacology. Br J Oral Maxillofac Surg. 1993;31:360
  9. Urquhart E. Analgesic agents and strategies in the dental pain model. J Dent. 1994;22:336
  10. Brown CR, Moodie JE, Dickie G, et al. Analgesic efficacy and safety of single-dose oral and intramuscular ketorolac tromethamine for postoperative pain. Pharmacotherapy. 1990;10:59S
  11. Singla N, Singla S, Minkowitz H, et al: Intranasal ketorolac (ROX-888) for postoperative pain: A phase 3, double-blind, randomized study. Presented at the Society for Ambulatory Anesthesia, Miami Beach, FL, May 1, 2008
  12. Brown C, Moodie J, Bisley E, et al. Intranasal ketorolac (ROX-888) for postoperative pain: A phase 3, double-blind, randomized study. Pain Med. 2009;10:1106
  13. Moodie JE, Brown CR, Bisley EJ, et al. The safety and analgesic efficacy of intranasal ketorolac in patients with postoperative pain. Anesth Analg. 2008;107:2025
  14. McAleer SD, Majid O, Venables E, et al. Pharmacokinetics and safety of ketorolac following single intranasal and intramuscular administration in healthy volunteers. J Clin Pharmacol. 2007;47:13
  15. Mroszczak E, Jung D, Yee J, et al. Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals. Pharmacotherapy. 1990;10:33S
  16. Partridge CG, Campbell JH, Alvarado F. The effect of platelet-altering medications on bleeding from minor oral surgery procedures. J Oral Maxillofac Surg. 2008;66:93
  17. Daniels SE, Grossman EH, Kuss ME, et al. A double-blind, randomized comparison of intramuscularly and intravenously administered parecoxib sodium versus ketorolac and placebo in a post-oral surgery pain model. Clin Ther. 2001;23:1018
  18. Eger EI, White PF, Bogetz MS. Clinical and economic factors important to anaesthetic choice for day-case surgery. Pharmacoeconomics. 2000;17:245
  19. Place RJ, Coloma M, White PF, et al. Ketorolac improves recovery after outpatient anorectal surgery. Dis Colon Rectum. 2000;43:804
  20. Rainer TH, Jacobs P, Ng YC, et al. Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: Double blind randomised controlled trial. BMJ. 2000;321:1247
  21. Rubinstein M, Finelli A, Moinzadeh A, et al. Outpatient laparoscopic pyeloplasty. Urology. 2005;66:41
  22. Thagaard KS, Jensen HH, Raeder J. Analgesic and antiemetic effect of ketorolac vs. betamethasone or dexamethasone after ambulatory surgery. Acta Anaesthesiol Scand. 2007;51:271
  23. Gordon SM. Translating science into the art of acute pain management. Compend Contin Educ Dent. 2007;28:248
  24. Pavlin DJ, Chen C, Penaloza DA, et al. Pain as a factor complicating recovery and discharge after ambulatory surgery. Anesth Analg. 2002;95:627
  25. Kamming D, Chung F, Williams D, et al. Pain management in ambulatory surgery. J Perianesth Nurs. 2004;19:174
  26. Shang AB, Gan TJ. Optimising postoperative pain management in the ambulatory patient. Drugs. 2003;63:855
  27. American Society of Anesthesiologists Task Force on Acute Pain Management: Practice guidelines for acute pain management in the perioperative setting. Anesthesiology. 2004;100:1573
  28. Pyati S, Gan TJ. Perioperative pain management. CNS Drugs. 2007;21:185

PII: S0278-2391(09)01977-6

doi: 10.1016/j.joms.2009.10.023

Journal of Oral and Maxillofacial Surgery
Volume 68, Issue 5 , Pages 1025-1031 , May 2010

Article Tools

* Image Usage & Resolution